Katan, Matilda

Multiple roles of phosphoinositide-specific phospholipase C isozymes

Suh, P.-G., Park, J.-I., Manzoli, L., Cocco, L., Peak, J. C., Katan, M., Fukami, K., Kataoka, T., Yun, S.-U., & Ryu, S.-H. (2008) · BMB Reports

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 501

Cold Urticaria, Immunodeficiency, and Autoimmunity Related to PLCG2 Deletions

Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., Subramanian, N., Bunney, T. D., Baxendale, R. W., Martins, M. S., et al. (2012) · New England Journal of Medicine

Immunodeficiency and Autoimmune DisordersInflammasome and immune disorders

Cited by 425

Phosphoinositide signalling in cancer: beyond PI3K and PTEN

Bunney, T. D., & Katan, M. (2010) · Nature Reviews Cancer

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 400

A Hypermorphic Missense Mutation in PLCG2 , Encoding Phospholipase Cγ2, Causes a Dominantly Inherited Autoinflammatory Disease with Immunodeficiency

Zhou, Q., Lee, G.-S., Brady, J., Datta, S., Katan, M., Sheikh, A., Martins, M. S., Bunney, T. D., Santich, B. H., Moir, S., et al. (2012) · The American Journal of Human Genetics

Immunodeficiency and Autoimmune DisordersInflammasome and immune disorders

Cited by 374

PLC regulation: emerging pictures for molecular mechanisms

Bunney, T. D., & Katan, M. (2011) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 182

Autoimmunity and Inflammation Due to a Gain-of-Function Mutation in Phospholipase Cγ2 that Specifically Increases External Ca2+ Entry

Yu, P., Constien, R., Dear, N., Katan, M., Hanke, P., Bunney, T. D., Kunder, S., Quintanilla-Martinez, L., Huffstadt, U., Schröder, A., et al. (2005) · Immunity

T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disorders

Cited by 177

Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane

Katan, M., & Cockcroft, S. (2020) · Essays in Biochemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 176

Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

Magno, L., Lessard, C. B., Martins, M., Lang, V., Cruz, P., Asi, Y., Katan, M., Bilsland, J., Lashley, T., Chakrabarty, P., et al. (2019) · Alzheimer's Research & Therapy

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 143

Dysfunction of phospholipase Cγ in immune disorders and cancer

Koss, H., Bunney, T. D., Behjati, S., & Katan, M. (2014) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 115

Phospholipase C families: Common themes and versatility in physiology and pathology

Katan, M., & Cockcroft, S. (2020) · Progress in Lipid Research

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 89

Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

Bunney, T. D., Esposito, D., Mas-Droux, C., Lamber, E., Baxendale, R. W., Martins, M., Cole, A., Svergun, D., Driscoll, P. C., & Katan, M. (2012) · Structure

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 88

Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa

Neves, J. F., Doffinger, R., Barcena-Morales, G., Martins, C., Papapietro, O., Plagnol, V., Curtis, J., Martins, M., Kumararatne, D., Cordeiro, A. I., et al. (2018) · Frontiers in Immunology

Immunodeficiency and Autoimmune DisordersInflammasome and immune disorders

Cited by 79

Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2

Bunney, T. D., Opaleye, O., Roe, S. M., Vatter, P., Baxendale, R. W., Walliser, C., Everett, K. L., Josephs, M. B., Christow, C., Rodrigues-Lima, F., et al. (2009) · Molecular Cell

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 72

Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations

Everett, K. L., Bunney, T. D., Yoon, Y., Rodrigues-Lima, F., Harris, R., Driscoll, P. C., Abe, K., Fuchs, H., Hrabé de Angelis, M., Yu, P., et al. (2009) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 63

Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations

Martín-Nalda, A., Fortuny, C., Rey, L., Bunney, T. D., Alsina, L., Esteve-Solé, A., Bull, D., Anton, M. C., Basagaña, M., Casals, F., et al. (2020) · Journal of Clinical Immunology

Immunodeficiency and Autoimmune DisordersInflammasome and immune disorders

Cited by 56

Rac regulates its effector phospholipase Cγ2 through interaction with a split pleckstrin homology domain

Walliser, C., Retlich, M., Harris, R., Everett, K. L., Josephs, M. B., Vatter, P., Esposito, D., Driscoll, P. C., Katan, M., Gierschik, P., et al. (2008) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 56

A novel N‐ethyl‐N‐nitrosourea–induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

Abe, K., Fuchs, H., Boersma, A., Hans, W., Yu, P., Kalaydjiev, S., Klaften, M., Adler, T., Calzada‐Wack, J., Mossbrugger, I., et al. (2011) · Arthritis & Rheumatism

Rheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus Research

Cited by 46

Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes

Liu, Y., Bunney, T. D., Khosa, S., Macé, K., Beckenbauer, K., Askwith, T., Maslen, S., Stubbs, C., de Oliveira, T. M., Sader, K., et al. (2020) · EBioMedicine

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 42

Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme

Le Huray, K. I. P., Bunney, T. D., Pinotsis, N., Kalli, A. C., & Katan, M. (2022) · Science Advances

Protein Kinase Regulation and GTPase SignalingLipid Membrane Structure and Behavior

Cited by 21

Requirements for distinct steps of phospholipase Cγ2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling

RODRIGUEZ, R., MATSUDA, M., STOREY, A., & KATAN, M. (2003) · Biochemical Journal

Protein Kinase Regulation and GTPase SignalingT-cell and B-cell Immunology

Cited by 20

Characterisation of molecular mechanisms for PLCγ2 disease-linked variants

Bunney, T. D., Kampyli, C., Gregory, A., & Katan, M. (2024) · Advances in Biological Regulation

Protein Kinase Regulation and GTPase SignalingChronic Lymphocytic Leukemia Research

Cited by 8

The PLC pathway

Everett, K. L., & Katan, M. (2016) · Encyclopedia of Cell Biology

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 3

The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function – Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation

Bull, D., Matte, J. C., Navarron, C. M., McIntyre, R., Whiting, P., Katan, M., Ducotterd, F., & Magno, L. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 3