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Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET

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Reverse Binding Mode of Phosphotyrosine Peptides with SH2 Protein

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The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance

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Contemporary diagnostic approach to atypical vascular lesion and angiosarcoma

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Grb-ing receptor activation by the tail

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Effect of acute acid-base disturbances on the phosphorylation of phospholipase C-γ1 and Erk1/2 in the renal proximal tubule

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SH2 Domain Structures and Interactions

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Investigation of Phospholipase Cγ1 Interaction with SLP76 Using Molecular Modeling Methods for Identifying Novel Inhibitors

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Нейропластичность мозга: мозговой нейротрофический фактор и протеинкиназные сигнальные пути

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Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation

Samarina, N., Ssebyatika, G. L., Tikla, T., Waldmann, J.-Y., Abere, B., Nanna, V., Marasco, M., Carlomagno, T., Krey, T., & Schulz, T. F. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009635 · Cited by 6 · see citing works

T Cell Receptor Pathway Mutations in Mature T Cell Lymphomas

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Mammalian PI-Phospholipase C Isozymes: Structural and Functional Insights and Roles in Health and Disease

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In unity, there is strength: Phase separation controls receptor tyrosine kinase signal transduction

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Exposed: The Many and Varied Roles of Phospholipase C γ SH2 Domains

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FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism

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Patients with Systemic Juvenile Idiopathic Arthritis (SJIA) Show Differences in Autoantibody Signatures Based on Disease Activity

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Activated PLCγ Breaking Loose

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The PLC pathway

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Integrated analysis of mRNA and long noncoding RNA profiles in peripheral blood mononuclear cells of patients with bronchial asthma

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Structure and modification

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Phospholipase C Isoform Functions in Immune Cells

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TCR Signal Strength Controls Dynamic NFAT Activation Threshold and Graded IRF4 Expression in CD8+ T Cells

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Molecular insight into the autoinhibition of a master regulator of lipid signalling in human disease

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Physiological Roles of Phospholipase Cγ and Its Mutations in Human Disease

Jang, H., Choi, J. H., & Chang, J. (2020) · Scholarworks@UNIST (Ulsan National Institute of Science and Technology) · doi:10.5352/jls.2020.30.9.826

PLAID and APLAID

Milner, J. D. (2020) · Springer eBooks · doi:10.1007/978-1-4614-9209-2_126-1

PLAID and APLAID

Milner, J. D. (2020) · Springer eBooks · doi:10.1007/978-1-4614-8678-7_126

The PLC Pathway

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Data from Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer

Cruz-Duarte, R., de Almeida, C. R., Negrão, M., Fernandes, A., Borralho, P., Sobral, D., Gallego-Paez, L. M., Machado, D., Gramaça, J., Vı́lchez, J. M., et al. (2023) · doi:10.1158/1078-0432.c.6531303

Data from Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer

Cruz-Duarte, R., de Almeida, C. R., Negrão, M., Fernandes, A., Borralho, P., Sobral, D., Gallego-Paez, L. M., Machado, D., Gramaça, J., Vı́lchez, J. M., et al. (2023) · doi:10.1158/1078-0432.c.6531303.v1

Phospholipase Cγ regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolismPreprint

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Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors

Bunney, T. D., Nyvall, H. G., Macrae, C., Lalović, D., Gregory, A., Huray, K. I. P. L., Harvey, N., Pinotsis, N., Kalli, A. C., Waudby, C. A., et al. (2025) · Biochemical Journal · doi:10.1042/bcj20253358

Análisis de redes complejas en sistemas biomoleculares

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Additional file 1 of Integrated analysis of mRNA and long noncoding RNA profiles in peripheral blood mononuclear cells of patients with bronchial asthma

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Integrated analysis of single-cell RNA sequencing, transcriptomics, and thermal proteome profiling identifies PLCG1 as the therapeutic target of isopimpinellin in treating rheumatoid arthritis

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A catalytically competent sperm PLCzeta variant causes fertilization failure through protein insufficiency

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Structural and Functional Integration of the PLC gamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation

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The crystal and cryo-EM structures of PLCγ2 reveal dynamic interdomain recognitions in autoinhibition

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Intramolecular Regulation of Phospholipase C-γ1 by Its C-Terminal Src Homology 2 Domain

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A dynamic constitutive and inducible binding of c-Cbl by PLCγ1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCγ1 activation in lymphocytes

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Solution structure properties and (dys)function of phospholipase Cγ

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