Ryffel, Bernhard

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Routy, B., Le Chatelier, E., Derosa, L., Duong, C. P. M., Alou, M. T., Daillère, R., Fluckiger, A., Messaoudene, M., Rauber, C., Roberti, M. P., et al. (2018) · Science

Cancer Immunotherapy and BiomarkersGut microbiota and health

Cited by 5,671

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

Viaud, S., Saccheri, F., Mignot, G., Yamazaki, T., Daillère, R., Hannani, D., Enot, D. P., Pfirschke, C., Engblom, C., Pittet, M. J., et al. (2013) · Science

Gut microbiota and healthCancer Immunotherapy and Biomarkers

Cited by 2,050

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine

Inflammasome and immune disordersImmunotherapy and Immune Responses

Cited by 1,898

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine

Gut microbiota and healthInflammatory Bowel Disease

Cited by 1,482

Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors

Kirson, E. D., Dbalý, V., Tovaryš, F., Vymazal, J., Soustiel, J. F., Itzhaki, A., Mordechovich, D., Steinberg-Shapira, S., Gurvich, Z., Schneiderman, R., et al. (2007) · Proceedings of the National Academy of Sciences

Electromagnetic Fields and Biological EffectsGlioma Diagnosis and Treatment

Cited by 894

Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis

Wollin, L., Maillet, I., Quesniaux, V., Holweg, A., & Ryffel, B. (2014) · The Journal of Pharmacology and Experimental Therapeutics

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and Treatments

Cited by 633

Caloric restriction mimetics enhance anticancer immunosurveillance

Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, D. P., Baracco, E. E., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., et al. (2016) · Cancer Cell

Autophagy in Disease and TherapyDietary Effects on Health

Cited by 542

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade

Ferrere, G., Tidjani Alou, M., Liu, P., Goubet, A.-G., Fidelle, M., Kepp, O., Durand, S., Iebba, V., Fluckiger, A., Daillère, R., et al. (2021) · JCI Insight

Diet and metabolism studiesCancer Immunotherapy and Biomarkers

Cited by 533

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

Gasse, P., Riteau, N., Charron, S., Girre, S., Fick, L., Pétrilli, V., Tschopp, J., Lagente, V., Quesniaux, V. F. J., Ryffel, B., et al. (2009) · American Journal of Respiratory and Critical Care Medicine

Inflammasome and immune disordersInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 410

Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis

Riteau, N., Gasse, P., Fauconnier, L., Gombault, A., Couegnat, M., Fick, L., Kanellopoulos, J., Quesniaux, V. F. J., Marchand-Adam, S., Crestani, B., et al. (2010) · American Journal of Respiratory and Critical Care Medicine

Adenosine and Purinergic SignalingInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 397

Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression

Chalmin, F., Mignot, G., Bruchard, M., Chevriaux, A., Végran, F., Hichami, A., Ladoire, S., Derangère, V., Vincent, J., Masson, D., et al. (2012) · Immunity

Adenosine and Purinergic SignalingT-cell and B-cell Immunology

Cited by 338

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

Legoux, F., Bellet, D., Daviaud, C., El Morr, Y., Darbois, A., Niort, K., Procopio, E., Salou, M., Gilet, J., Ryffel, B., et al. (2019) · Science

T-cell and B-cell ImmunologyGut microbiota and health

Cited by 320

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells

Végran, F., Berger, H., Boidot, R., Mignot, G., Bruchard, M., Dosset, M., Chalmin, F., Rébé, C., Dérangère, V., Ryffel, B., et al. (2014) · Nature Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 228

NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice

Marín‐Aguilar, F., Lechuga‐Vieco, A. V., Alcocer‐Gómez, E., Castejón‐Vega, B., Lucas, J., Garrido, C., Peralta‐Garcia, A., Pérez‐Pulido, A. J., Varela‐López, A., Quiles, J. L., et al. (2020) · Aging Cell

Inflammasome and immune disordersGenetics, Aging, and Longevity in Model Organisms

Cited by 220

IL-1 and IL-23 Mediate Early IL-17A Production in Pulmonary Inflammation Leading to Late Fibrosis

Gasse, P., Riteau, N., Vacher, R., Michel, M.-L., Fautrel, A., di Padova, F., Fick, L., Charron, S., Lagente, V., Eberl, G., et al. (2011) · PLoS ONE

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisIL-33, ST2, and ILC Pathways

Cited by 208

Inhibition of the NLRP3 inflammasome prevents ovarian aging

Navarro-Pando, J. M., Alcocer-Gómez, E., Castejón-Vega, B., Navarro-Villarán, E., Condés-Hervás, M., Mundi-Roldan, M., Muntané, J., Pérez-Pulido, A. J., Bullon, P., Wang, C., et al. (2021) · Science Advances

Inflammasome and immune disordersReproductive Biology and Fertility

Cited by 206

Toll-Like Receptor 2 Is Required for Optimal Control of Listeria monocytogenes Infection

Torres, D., Barrier, M., Bihl, F., Quesniaux, V. J. F., Maillet, I., Akira, S., Ryffel, B., & Erard, F. (2004) · Infection and Immunity

Immune Response and InflammationImmune responses and vaccinations

Cited by 191

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

Alcocer-Gómez, E., Ulecia-Morón, C., Marín-Aguilar, F., Rybkina, T., Casas-Barquero, N., Ruiz-Cabello, J., Ryffel, B., Apetoh, L., Ghiringhelli, F., Bullón, P., et al. (2016) · Molecular Neurobiology

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 172

Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs

Kirson, E. D., Giladi, M., Gurvich, Z., Itzhaki, A., Mordechovich, D., Schneiderman, R. S., Wasserman, Y., Ryffel, B., Goldsher, D., & Palti, Y. (2009) · Clinical & Experimental Metastasis

Electromagnetic Fields and Biological EffectsMicrobial Inactivation Methods

Cited by 171

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

Yonekura, S., Terrisse, S., Alves Costa Silva, C., Lafarge, A., Iebba, V., Ferrere, G., Goubet, A.-G., Fahrner, J.-E., Lahmar, I., Ueda, K., et al. (2022) · Cancer Discovery

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 112

B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis

François, A., Gombault, A., Villeret, B., Alsaleh, G., Fanny, M., Gasse, P., Adam, S. M., Crestani, B., Sibilia, J., Schneider, P., et al. (2015) · Journal of Autoimmunity

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTransplantation: Methods and Outcomes

Cited by 109

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T H 1 and T H 9 cells

Benoit-Lizon, I., Jacquin, E., Rivera Vargas, T., Richard, C., Roussey, A., Dal Zuffo, L., Martin, T., Melis, A., Vinokurova, D., Shahoei, S. H., et al. (2022) · Journal for ImmunoTherapy of Cancer

interferon and immune responsesImmunotherapy and Immune Responses

Cited by 85

An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates With Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection

Agoro, R., Benmerzoug, S., Rose, S., Bouyer, M., Gozzelino, R., Garcia, I., Ryffel, B., Quesniaux, V. F. J., & Mura, C. (2017) · The Journal of Infectious Diseases

Tuberculosis Research and EpidemiologyIron Metabolism and Disorders

Cited by 22