Lowell, Bradford B.

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 4,139

Role of leptin in the neuroendocrine response to fasting

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 3,117

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres

Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature

Muscle Physiology and DisordersAdipose Tissue and Metabolism

Cited by 2,546

Mitochondrial dysfunction and type 2 diabetes

Lowell, B. B., & Shulman, G. I. (2005) · Science

Mitochondrial Function and PathologyPancreatic function and diabetes

Cited by 2,070

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,660

Towards a molecular understanding of adaptive thermogenesis

Lowell, B. B., & Spiegelman, B. M. (2000) · Nature

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 1,630

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation

Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

Cited by 1,578

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

Cohen, J. Y., Haesler, S., Vong, L., Lowell, B. B., & Uchida, N. (2012) · Nature

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 1,318

Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,162

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature

Adipose Tissue and MetabolismRegulation of Appetite and Obesity

Cited by 1,075

Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network

McHugh, T. J., Jones, M. W., Quinn, J. J., Balthasar, N., Coppari, R., Elmquist, J. K., Lowell, B. B., Fanselow, M. S., Wilson, M. A., & Tonegawa, S. (2007) · Science

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 958

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 935

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 917

Adipose tissue mass can be regulated through the vasculature

Rupnick, M. A., Panigrahy, D., Zhang, C.-Y., Dallabrida, S. M., Lowell, B. B., Langer, R., & Folkman, M. J. (2002) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismAngiogenesis and VEGF in Cancer

Cited by 845

A molecular census of arcuate hypothalamus and median eminence cell types

Campbell, J. N., Macosko, E. Z., Fenselau, H., Pers, T. H., Lyubetskaya, A., Tenen, D., Goldman, M., Verstegen, A. M. J., Resch, J. M., McCarroll, S. A., et al. (2017) · Nature Neuroscience

Regulation of Appetite and ObesitySingle-cell and spatial transcriptomics

Cited by 817

Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia

Sarraf, P., Frederich, R. C., Turner, E. M., Ma, G., Jaskowiak, N. T., Rivet, D. J., Flier, J. S., Lowell, B. B., Fraker, D. L., & Alexander, H. R. (1997) · The Journal of Experimental Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 791

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 791

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F. P., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) · Nature Medicine

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 743

Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

Puigserver, P., Rhee, J., Lin, J., Wu, Z., Yoon, J. C., Zhang, C.-Y., Krauss, S., Mootha, V. K., Lowell, B. B., & Spiegelman, B. M. (2001) · Molecular Cell

Adipose Tissue and MetabolismMuscle Physiology and Disorders

Cited by 732

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

Danial, N. N., Gramm, C. F., Scorrano, L., Zhang, C.-Y., Krauss, S., Ranger, A. M., Robert Datta, S., Greenberg, M. E., Licklider, L. J., Lowell, B. B., et al. (2003) · Nature

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 705

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C.-Y., Xu, C., Vianna, C. R., Balthasar, N., Lee, C. E., et al. (2007) · Nature

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 700

Energy metabolism in uncoupling protein 3 gene knockout mice

Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 677

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

Rossi, J., Balthasar, N., Olson, D., Scott, M., Berglund, E., Lee, C. E., Choi, M. J., Lauzon, D., Lowell, B. B., & Elmquist, J. K. (2011) · Cell Metabolism

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 672

Sensory neurons that detect stretch and nutrients in the digestive system

Williams, E. K., Chang, R. B., Strochlic, D. E., Umans, B. D., Lowell, B. B., & Liberles, S. D. (2016) · Cell

Gastrointestinal motility and disordersNeurobiology and Insect Physiology Research

Cited by 645