Lowell, Bradford B.

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

Krashes, M. J., Shah, B. P., Madara, J. C., Olson, D. P., Strochlic, D. E., Garfield, A. S., Vong, L., Pei, H., Watabe-Uchida, M., Uchida, N., et al. (2014) · Nature

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., et al. (2014) · Cell

Pain Mechanisms and TreatmentsIon Channels and Receptors

Cited by 582

The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C., et al. (2005) · Cell Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 457

The hypothalamus

Saper, C. B., & Lowell, B. B. (2014) · Current Biology

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 423

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia

Tong, Q., Ye, C., McCrimmon, R. J., Dhillon, H., Choi, B., Kramer, M. D., Yu, J., Yang, Z., Christiansen, L. M., Lee, C. E., et al. (2007) · Cell Metabolism

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 413

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Krauss, S., Zhang, C.-Y., Scorrano, L., Dalgaard, L. T., St-Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 401

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 391

EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses

Lazarus, M., Yoshida, K., Coppari, R., Bass, C. E., Mochizuki, T., Lowell, B. B., & Saper, C. B. (2007) · Nature Neuroscience

Thermal Regulation in MedicinePain Mechanisms and Treatments

Cited by 367

Distinct subpopulations of nucleus accumbens dynorphin neurons drive aversion and reward

Al-Hasani, R., McCall, J. G., Shin, G., Gomez, A. M., Schmitz, G. P., Bernardi, J. M., Pyo, C.-O., Park, S. I., Marcinkiewcz, C. M., Crowley, N. A., et al. (2015) · Neuron

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 345

Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion

van de Wall, E., Leshan, R., Xu, A. W., Balthasar, N., Coppari, R., Liu, S. M., Jo, Y. H., MacKenzie, R. G., Allison, D. B., Dun, N. J., et al. (2008) · Endocrinology

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 338

Homeostatic circuits selectively gate food cue responses in insular cortex

Livneh, Y., Ramesh, R. N., Burgess, C. R., Levandowski, K. M., Madara, J. C., Fenselau, H., Goldey, G. J., Diaz, V. E., Jikomes, N., Resch, J. M., et al. (2017) · Nature

Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

Cited by 316

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

Danial, N. N., Walensky, L. D., Zhang, C.-Y., Choi, C. S., Fisher, J. K., Molina, A. J. A., Datta, S. R., Pitter, K. L., Bird, G. H., Wikstrom, J. D., et al. (2008) · Nature Medicine

Pancreatic function and diabetesCell death mechanisms and regulation

Cited by 307

Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone

Liu, T., Kong, D., Shah, B. P., Ye, C., Koda, S., Saunders, A., Ding, J. B., Yang, Z., Sabatini, B. L., & Lowell, B. B. (2012) · Neuron

Regulation of Appetite and ObesityNeuroscience and Neuropharmacology Research

Cited by 296

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

Mandelblat-Cerf, Y., Ramesh, R. N., Burgess, C. R., Patella, P., Yang, Z., Lowell, B. B., & Andermann, M. L. (2015) · eLife

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 290

Identification of spinal circuits involved in touch-evoked dynamic mechanical pain

Cheng, L., Duan, B., Huang, T., Zhang, Y., Chen, Y., Britz, O., Garcia-Campmany, L., Ren, X., Vong, L., Lowell, B. B., et al. (2017) · Nature Neuroscience

Pain Mechanisms and TreatmentsIon Channels and Receptors

Cited by 240

A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH

Fenselau, H., Campbell, J. N., Verstegen, A. M. J., Madara, J. C., Xu, J., Shah, B. P., Resch, J. M., Yang, Z., Mandelblat-Cerf, Y., Livneh, Y., et al. (2017) · Nature Neuroscience

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 233

Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

Joseph, J. W., Koshkin, V., Zhang, C.-Y., Wang, J., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2002) · Diabetes

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 220

Melanocortin 4 Receptors Reciprocally Regulate Sympathetic and Parasympathetic Preganglionic Neurons

Sohn, J.-W., Harris, L. E., Berglund, E. D., Liu, T., Vong, L., Lowell, B. B., Balthasar, N., Williams, K. W., & Elmquist, J. K. (2013) · Cell

Regulation of Appetite and ObesityNeuropeptides and Animal Physiology

Cited by 218

GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure

Kong, D., Tong, Q., Ye, C., Koda, S., Fuller, P. M., Krashes, M. J., Vong, L., Ray, R. S., Olson, D. P., & Lowell, B. B. (2012) · Cell

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 215

Dynamic GABAergic afferent modulation of AgRP neurons

Garfield, A. S., Shah, B. P., Burgess, C. R., Li, M. M., Li, C., Steger, J. S., Madara, J. C., Campbell, J. N., Kroeger, D., Scammell, T. E., et al. (2016) · Nature Neuroscience

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 211

Estimation of Current and Future Physiological States in Insular Cortex

Livneh, Y., Sugden, A. U., Madara, J. C., Essner, R. A., Flores, V. I., Sugden, L. A., Resch, J. M., Lowell, B. B., & Andermann, M. L. (2020) · Neuron

Regulation of Appetite and ObesityMemory and Neural Mechanisms

Cited by 209

Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression

Joseph, J. W., Koshkin, V., Saleh, M. C., Sivitz, W. I., Zhang, C.-Y., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2004) · Journal of Biological Chemistry

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 206

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

Pleil, K. E., Rinker, J. A., Lowery-Gionta, E. G., Mazzone, C. M., McCall, N. M., Kendra, A. M., Olson, D. P., Lowell, B. B., Grant, K. A., Thiele, T. E., et al. (2015) · Nature Neuroscience

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 195

The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits

Li, M. M., Madara, J. C., Steger, J. S., Krashes, M. J., Balthasar, N., Campbell, J. N., Resch, J. M., Conley, N. J., Garfield, A. S., & Lowell, B. B. (2019) · Neuron

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 195