Christoffels, Vincent M.

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Hoogaars, W. M. H., Engel, A., Brons, J. F., Verkerk, A. O., de Lange, F. J., Wong, L. Y. E., Bakker, M. L., Clout, D. E., Wakker, V., Barnett, P., et al. (2007) · Genes & Development

Congenital heart defects researchCardiac electrophysiology and arrhythmias

Cited by 409

Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation†

Lüdtke, T. H. ‐., Christoffels, V. M., Petry, M., & Kispert, A. (2009) · Hepatology

Liver physiology and pathologyDevelopmental Biology and Gene Regulation

Cited by 117

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program

van Eif, V., Stefanovic, S., van Duijvenboden, K., Bakker, M., Wakker, V., de Gier-de Vries, C., Zaffran, S., Verkerk, A. O., Boukens, B. J., & Christoffels, V. (2019) · Development

Cardiac electrophysiology and arrhythmiasCongenital heart defects research

Cited by 76

Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis

Trowe, M.-O., Zhao, L., Weiss, A.-C., Christoffels, V., Epstein, D. J., & Kispert, A. (2013) · Development

Developmental Biology and Gene RegulationHedgehog Signaling Pathway Studies

Cited by 72

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung

Lüdtke, T. H., Rudat, C., Wojahn, I., Weiss, A.-C., Kleppa, M.-J., Kurz, J., Farin, H. F., Moon, A., Christoffels, V. M., & Kispert, A. (2016) · Developmental Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 69

Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction

Mohan, R. A., Mommersteeg, M. T. M., Domínguez, J. N., Choquet, C., Wakker, V., de Gier-de Vries, C., Boink, G. J. J., Boukens, B. J., Miquerol, L., Verkerk, A. O., et al. (2018) · Development

Congenital heart defects researchCardiac electrophysiology and arrhythmias

Cited by 50

TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme

Aydoğdu, N., Rudat, C., Trowe, M.-O., Kaiser, M., Lüdtke, T. H., Taketo, M. M., Christoffels, V. M., Moon, A., & Kispert, A. (2018) · Development

Renal and related cancersDevelopmental Biology and Gene Regulation

Cited by 41

T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system

Mohan, R. A., Bosada, F. M., van Weerd, J. H., van Duijvenboden, K., Wang, J., Mommersteeg, M. T. M., Hooijkaas, I. B., Wakker, V., de Gier-de Vries, C., Coronel, R., et al. (2020) · Proceedings of the National Academy of Sciences

Cardiac electrophysiology and arrhythmiasCongenital heart defects research

Cited by 39

Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression

van Eif, V. W. W., Stefanovic, S., Mohan, R. A., & Christoffels, V. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Congenital heart defects researchCardiac electrophysiology and arrhythmias

Cited by 30

Transcriptional Repressor Tbx3 Is Required for the Hormone-Sensing Cell Lineage in Mammary Epithelium

Kunasegaran, K., Ho, V., Chang, T. H. T., De Silva, D., Bakker, M. L., Christoffels, V. M., & Pietersen, A. M. (2014) · PLoS ONE

Estrogen and related hormone effectsDevelopmental Biology and Gene Regulation

Cited by 18

Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction

van Weerd, J. H., Mohan, R. A., van Duijvenboden, K., Hooijkaas, I. B., Wakker, V., Boukens, B. J., Barnett, P., & Christoffels, V. M. (2020) · eLife

Cardiac electrophysiology and arrhythmiasGenomics and Chromatin Dynamics

Cited by 12

TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration

Melzer, M. K., Schirge, S., Gout, J., Arnold, F., Srinivasan, D., Burtscher, I., Allgöwer, C., Mulaw, M., Zengerling, F., Günes, C., et al. (2023) · BMC Biology

Pancreatic function and diabetesPancreatitis Pathology and Treatment

Cited by 5