T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system
Open accessAbstract
Significance: Genome-wide association studies have identified common noncoding variants associated with ECG parameters in the TBX3 locus, suggesting that a modest change in TBX3/Tbx3 expression level affects heart function. We characterized the morphology, physiology, and gene expression profile of the atrioventricular conduction system in a Tbx3 haploinsufficient mouse model. We identified Tbx3-dependent regulatory DNA elements active in the atrioventricular conduction system and validated the functionality of these elements in vivo. Using genome editing, we deleted a regulatory DNA element from the mouse genome and show it drives expression of Cacna1g in the cardiac conduction system. Our study unveils a Tbx3-dependent gene regulatory network in the AV conduction system that contributes to heart electrophysiology.
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The Tbx3-Venus reporter system is validated.
“To visualize the activity of the murine Tbx3 promoter at the protein level, we used a validated Tbx3-Venus (Tbx3tm1(Venus)Vmc) [11, 42–47] reporter system (Fig. 2a).”
From TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration (2023) · cites this paper as [44]
The available indexed passages labeled Abstract contain citation metadata and keywords, but no description or validation of a Tbx3-Venus reporter. Searches for “Venus,” “validated reporter system,” and the allele name found no relevant passage, so this copy cannot establish the claim. (LLM, conf=0.73)
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Self-citation
- Authors
- Mohan, R. A., Bosada, F. M., van Weerd, J. H., van Duijvenboden, K., Wang, J., Mommersteeg, M. T. M., Hooijkaas, I. B., Wakker, V., de Gier-de Vries, C., Coronel, R., Boink, G. J. J., Bakkers, J., Barnett, P., Boukens, B. J., & Christoffels, V. M.
- Affiliations
- Amsterdam University Medical Centers (NL)
- Department of Medical Biology, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;
- University of Oxford (GB)
- University Medical Center Utrecht (NL)
- Corresponding author
- Christoffels, Vincent M.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2020-07-16
- Volume
- 117
- Issue
- 31
- Pages
- 18617-18626
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC7414162
- OpenAlex
- W3042543031
- Cited by
- 39
- References
- 71
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 8
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- Fondation Leducq (14CVD01)
- Hartstichting (2016T047, 2014T065)
- ZonMw (016.156.162)
- EC | FP7 | FP7 Ideas: European Research Council (714866)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- TBX3, atrioventricular conduction system, haploinsufficiency, gene regulatory networks, CACNA1G, cardiac electrophysiology, non-coding variants, ECG parameters, transcriptional regulation, mouse model
- MeSH terms
- Animals, Arrhythmias, Cardiac, Atrioventricular Node, Mice, Transgenic, Mutation, Ryanodine Receptor Calcium Release Channel, Calcium Channels, T-Type, T-Box Domain Proteins, Mice, Transcriptome
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