Lowe, Scott W.

A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation

Narita, M., Narita, M., Krizhanovsky, V., Nuñez, S., Chicas, A., Hearn, S. A., Myers, M. P., & Lowe, S. W. (2006) · Cell

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 629

Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice

Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., & Benezra, R. (2007) · Cancer Cell

Microtubule and mitosis dynamicsCancer-related Molecular Pathways

Cited by 612

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

Juric, D., Castel, P., Griffith, M., Griffith, O. L., Won, H. H., Ellis, H., Ebbesen, S. H., Ainscough, B. J., Ramu, A., Iyer, G., et al. (2015) · Nature

PI3K/AKT/mTOR signaling in cancerCancer Genomics and Diagnostics

Cited by 588

A rectal cancer organoid platform to study individual responses to chemoradiation

Ganesh, K., Wu, C., O’Rourke, K. P., Szeglin, B. C., Zheng, Y., Sauvé, C.-E. G., Adileh, M., Wasserman, I., Marco, M. R., Kim, A. S., et al. (2019) · Nature Medicine

Cancer Cells and MetastasisColorectal Cancer Surgical Treatments

Cited by 569

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control

Hernando, E., Nahlé, Z., Juan, G., Diaz-Rodriguez, E., Alaminos, M., Hemann, M., Michel, L., Mittal, V., Gerald, W., Benezra, R., et al. (2004) · Nature

Microtubule and mitosis dynamicsCancer-related Molecular Pathways

Cited by 562

PML is induced by oncogenic ras and promotes premature senescence

Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., & Lowe, S. W. (2000) · Genes & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 536

Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma

Xu, M. Z., Yao, T., Lee, N. P. Y., Ng, I. O. L., Chan, Y., Zender, L., Lowe, S. W., Poon, R. T. P., & Luk, J. M. (2009) · Cancer

Hippo pathway signaling and YAP/TAZHepatocellular Carcinoma Treatment and Prognosis

Cited by 528

Dissecting eIF4E action in tumorigenesis

Wendel, H.-G., Silva, R. L. A., Malina, A., Mills, J. R., Zhu, H., Ueda, T., Watanabe-Fukunaga, R., Fukunaga, R., Teruya-Feldstein, J., Pelletier, J., et al. (2007) · Genes & Development

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 487

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

Weissmueller, S., Manchado, E., Saborowski, M., Morris, J. P., Wagenblast, E., Davis, C. A., Moon, S.-H., Pfister, N. T., Tschaharganeh, D. F., Kitzing, T., et al. (2014) · Cell

Cancer-related Molecular PathwaysPancreatic and Hepatic Oncology Research

Cited by 466

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

Schmitt, C. A., McCurrach, M. E., de Stanchina, E., Wallace-Brodeur, R. R., & Lowe, S. W. (1999) · Genes & Development

Cancer-related Molecular PathwaysLymphoma Diagnosis and Treatment

Cited by 458

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Ruscetti, M., Morris, J. P., Mezzadra, R., Russell, J., Leibold, J., Romesser, P. B., Simon, J., Kulick, A., Ho, Y.-J., Fennell, M., et al. (2020) · Cell

Pancreatic and Hepatic Oncology ResearchTelomeres, Telomerase, and Senescence

Cited by 424

Direct coupling of the cell cycle and cell death machinery by E2F

Nahle, Z., Polakoff, J., Davuluri, R. V., McCurrach, M. E., Jacobson, M. D., Narita, M., Zhang, M. Q., Lazebnik, Y., Bar-Sagi, D., & Lowe, S. W. (2002) · Nature Cell Biology

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 421

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

Ruscetti, M., Leibold, J., Bott, M. J., Fennell, M., Kulick, A., Salgado, N. R., Chen, C.-C., Ho, Y.-J., Sanchez-Rivera, F. J., Feucht, J., et al. (2018) · Science

Immune Cell Function and InteractionTelomeres, Telomerase, and Senescence

Cited by 415

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

Tasdemir, N., Banito, A., Roe, J.-S., Alonso-Curbelo, D., Camiolo, M., Tschaharganeh, D. F., Huang, C.-H., Aksoy, O., Bolden, J. E., Chen, C.-C., et al. (2016) · Cancer Discovery

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 415

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

Iannello, A., Thompson, T. W., Ardolino, M., Lowe, S. W., & Raulet, D. H. (2013) · Journal of Experimental Medicine

Immune Cell Function and InteractionTelomeres, Telomerase, and Senescence

Cited by 414

A combinatorial strategy for treating KRAS-mutant lung cancer

Manchado, E., Weissmueller, S., Morris, J. P., Chen, C.-C., Wullenkord, R., Lujambio, A., de Stanchina, E., Poirier, J. T., Gainor, J. F., Corcoran, R. B., et al. (2016) · Nature

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

Cited by 403

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

Chicas, A., Wang, X., Zhang, C., McCurrach, M., Zhao, Z., Mert, O., Dickins, R. A., Narita, M., Zhang, M., & Lowe, S. W. (2010) · Cancer Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 388

Optimized base editors enable efficient editing in cells, organoids and mice

Zafra, M. P., Schatoff, E. M., Katti, A., Foronda, M., Breinig, M., Schweitzer, A. Y., Simon, A., Han, T., Goswami, S., Montgomery, E., et al. (2018) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 347

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Lito, P., Saborowski, A., Yue, J., Solomon, M., Joseph, E., Gadal, S., Saborowski, M., Kastenhuber, E., Fellmann, C., Ohara, K., et al. (2014) · Cancer Cell

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 324

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

Premsrirut, P. K., Dow, L. E., Kim, S. Y., Camiolo, M., Malone, C. D., Miething, C., Scuoppo, C., Zuber, J., Dickins, R. A., Kogan, S. C., et al. (2011) · Cell

RNA Interference and Gene DeliveryAnimal Genetics and Reproduction

Cited by 315

PML Is a Direct p53 Target that Modulates p53 Effector Functions

de Stanchina, E., Querido, E., Narita, M., Davuluri, R. V., Pandolfi, P. P., Ferbeyre, G., & Lowe, S. W. (2004) · Molecular Cell

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 312

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

Chandra, T., Kirschner, K., Thuret, J.-Y., Pope, B. D., Ryba, T., Newman, S., Ahmed, K., Samarajiwa, S. A., Salama, R., Carroll, T., et al. (2012) · Molecular Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 308

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

Dilly, J., Hoffman, M. T., Abbassi, L., Li, Z., Paradiso, F., Parent, B. D., Hennessey, C. J., Jordan, A. C., Morgado, M., Dasgupta, S., et al. (2024) · Cancer Discovery

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 308

Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging

Harmsen, S., Huang, R., Wall, M. A., Karabeber, H., Samii, J. M., Spaliviero, M., White, J. R., Monette, S., O’Connor, R., Pitter, K. L., et al. (2015) · Science Translational Medicine

Gold and Silver Nanoparticles Synthesis and ApplicationsSpectroscopy Techniques in Biomedical and Chemical Research

Cited by 296