Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging
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Surface-enhanced resonance Raman scattering gold nanostars allow detection of macro- and microscopic foci of premalignant and cancerous lesions in vivo.
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“As such, SERS has not only been used to improve the sensitivity of (multi)analyte detection in bioanalytical assays [3-5], but to generate highly sensitive (targeted) Raman imaging probes for early and comprehensive disease detection in vivo [6-8].”
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- Authors
- Harmsen, S., Huang, R., Wall, M. A., Karabeber, H., Samii, J. M., Spaliviero, M., White, J. R., Monette, S., O’Connor, R., Pitter, K. L., Sastra, S. A., Saborowski, M., Holland, E. C., Singer, S., Olive, K. P., Lowe, S. W., Blasberg, R. G., & Kircher, M. F.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Columbia University Irving Medical Center (US)
- University of Washington (US)
- Corresponding author
- Harmsen, Stefan
- Huang, Ruimin
- Kircher, Moritz F.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-01-21
- Volume
- 7
- Issue
- 271
- Pages
- 271ra7-271ra7
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4414254
- OpenAlex
- W2106635129
- Cited by
- 296
- References
- 44
- Citations by year
- 2026: 17 · 2025: 14 · 2024: 23 · 2023: 22 · 2022: 28 · 2021: 27 · 2020: 23 · 2019: 33 · 2018: 35 · 2017: 34 · 2016: 28 · 2015: 12
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01 EB017748, K08 CA163961)
- NCI (2R25-CA096945, P50 CA140146)
- Damon Runyon Cancer Research Foundation (DRR-29-14)
- The Dana Foundation Brain and Immuno-Imaging
- Dana Neuroscience Scholar Award
- Bayer HealthCare Pharmaceuticals/Radiological Society of North America Research Scholar
- MSKCC Center for Molecular Imaging and Nanotechnology
- MSKCC Technology Development
- Geoffrey Beene Cancer Research Center at MSKCC
- Shared Resources Award
- MSKCC Brain Tumor Center
- Society of MSKCC Research
- National Science Foundation Integrative Graduate Education and Research Traineeship (IGERT 0965983)
- MSKCC NIH Core (P30-CA008748)
- Topics
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- surface-enhanced resonance Raman scattering, tumor imaging, tumor margin visualization, precancerous lesions, pancreatic cancer, breast cancer, prostate cancer, sarcoma, xenograft models
- MeSH terms
- Animals, Diagnostic Imaging, Disease Models, Animal, Female, Humans, Neoplasm Metastasis, Neoplasms, Pinocytosis, Precancerous Conditions, Spectrum Analysis, Raman, Tissue Distribution, Cell Line, Tumor, Nanoparticles
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