Krogan, Nevan J.

Functional Overlap and Regulatory Links Shape Genetic Interactions between Signaling Pathways

van Wageningen, S., Kemmeren, P., Lijnzaad, P., Margaritis, T., Benschop, J. J., de Castro, I. J., van Leenen, D., Groot Koerkamp, M. J. A., Ko, C. W., Miles, A. J., et al. (2010) · Cell

Fungal and yeast genetics researchBioinformatics and Genomic Networks

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Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways

Sigg, M. A., Menchen, T., Lee, C., Johnson, J., Jungnickel, M. K., Choksi, S. P., Garcia, G., Busengdal, H., Dougherty, G. W., Pennekamp, P., et al. (2017) · Developmental Cell

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

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Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Mendiola, A. S., Yan, Z., Dixit, K., Johnson, J. R., Bouhaddou, M., Meyer-Franke, A., Shin, M.-G., Yong, Y., Agrawal, A., MacDonald, E., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 124

Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1

Jeng, M. Y., Hull, P. A., Fei, M., Kwon, H.-S., Tsou, C.-L., Kasler, H., Ng, C.-P., Gordon, D. E., Johnson, J., Krogan, N., et al. (2018) · Journal of Experimental Medicine

Sirtuins and Resveratrol in MedicineT-cell and B-cell Immunology

Cited by 121

Fibrin drives thromboinflammation and neuropathology in COVID-19

Ryu, J. K., Yan, Z., Montano, M., Sozmen, E. G., Dixit, K., Suryawanshi, R. K., Matsui, Y., Helmy, E., Kaushal, P., Makanani, S. K., et al. (2024) · Nature

COVID-19 Clinical Research StudiesBlood properties and coagulation

Cited by 116

Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function

Orr, A. L., Kim, C., Jimenez-Morales, D., Newton, B. W., Johnson, J. R., Krogan, N. J., Swaney, D. L., & Mahley, R. W. (2019) · Journal of Alzheimer's Disease

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 103

Cullin E3 Ligases and Their Rewiring by Viral Factors

Mahon, C., Krogan, N., Craik, C., & Pick, E. (2014) · Biomolecules

Ubiquitin and proteasome pathwaysNF-κB Signaling Pathways

Cited by 101

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold

Chou, S., Upton, H., Bao, K., Schulze-Gahmen, U., Samelson, A. J., He, N., Nowak, A., Lu, H., Krogan, N. J., Zhou, Q., et al. (2013) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsHIV Research and Treatment

Cited by 93

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

Thorne, L. G., Bouhaddou, M., Reuschl, A.-K., Zuliani-Alvarez, L., Polacco, B., Pelin, A., Batra, J., Whelan, M. V. X., Ummadi, M., Rojc, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

SARS-CoV-2 and COVID-19 Researchinterferon and immune responses

Cited by 91

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

Gupta, M., Azumaya, C. M., Moritz, M., Pourmal, S., Diallo, A., Merz, G. E., Jang, G., Bouhaddou, M., Fossati, A., Brilot, A. F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

SARS-CoV-2 and COVID-19 ResearchAdvanced Electron Microscopy Techniques and Applications

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GPS-Prot: A web-based visualization platform for integrating host-pathogen interaction data

Fahey, M. E., Bennett, M. J., Mahon, C., Jäger, S., Pache, L., Kumar, D., Shapiro, A., Rao, K., Chanda, S. K., Craik, C. S., et al. (2011) · BMC Bioinformatics

Bioinformatics and Genomic NetworksHIV Research and Treatment

Cited by 87

De novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography

Chen, Z., Shiozaki, M., Haas, K. M., Zhao, S., Guo, C., Polacco, B. J., Yu, Z., Krogan, N. J., Kaake, R. M., Vale, R. D., et al. (2022) · Cell

Advanced Electron Microscopy Techniques and ApplicationsSperm and Testicular Function

Cited by 82

De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking

Chen, Z., Shiozaki, M., Haas, K. M., Skinner, W. M., Zhao, S., Guo, C., Polacco, B. J., Yu, Z., Krogan, N. J., Lishko, P. V., et al. (2023) · Cell

Advanced Electron Microscopy Techniques and ApplicationsSperm and Testicular Function

Cited by 82

Interpretation of cancer mutations using a multiscale map of protein systems

Zheng, F., Kelly, M. R., Ramms, D. J., Heintschel, M. L., Tao, K., Tutuncuoglu, B., Lee, J. J., Ono, K., Foussard, H., Chen, M., et al. (2021) · Science

Bioinformatics and Genomic NetworksCancer Genomics and Diagnostics

Cited by 81

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria

Fay, A., Czudnochowski, N., Rock, J. M., Johnson, J. R., Krogan, N. J., Rosenberg, O., & Glickman, M. S. (2019) · mBio

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 65

Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis

Paulo, E., Wu, D., Wang, Y., Zhang, Y., Wu, Y., Swaney, D. L., Soucheray, M., Jimenez-Morales, D., Chawla, A., Krogan, N. J., et al. (2018) · Scientific Reports

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 59

Thioredoxin-related Protein 32 Is an Arsenite-regulated Thiol Reductase of the Proteasome 19 S Particle

Wiseman, R. L., Chin, K.-T., Haynes, C. M., Stanhill, A., Xu, C.-F., Roguev, A., Krogan, N. J., Neubert, T. A., & Ron, D. (2009) · Journal of Biological Chemistry

Redox biology and oxidative stressUbiquitin and proteasome pathways

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Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13

Kim, S. K., Dickinson, M. S., Finer-Moore, J., Guan, Z., Kaake, R. M., Echeverria, I., Chen, J., Pulido, E. H., Sali, A., Krogan, N. J., et al. (2023) · Nature Structural & Molecular Biology

Microbial Natural Products and BiosynthesisTuberculosis Research and Epidemiology

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Genetic interaction mapping informs integrative structure determination of protein complexes

Braberg, H., Echeverria, I., Bohn, S., Cimermancic, P., Shiver, A., Alexander, R., Xu, J., Shales, M., Dronamraju, R., Jiang, S., et al. (2020) · Science

Protein Structure and DynamicsEnzyme Structure and Function

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Reduced endosomal microautophagy activity in aging associates with enhanced exocyst‐mediated protein secretion

Krause, G. J., Diaz, A., Jafari, M., Khawaja, R. R., Agullo‐Pascual, E., Santiago‐Fernández, O., Richards, A. L., Chen, K., Dmitriev, P., Sun, Y., et al. (2022) · Aging Cell

Autophagy in Disease and TherapyCellular transport and secretion

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Dispersed Sites of HIV Vif-Dependent Polyubiquitination in the DNA Deaminase APOBEC3F

Albin, J. S., Anderson, J. S., Johnson, J. R., Harjes, E., Matsuo, H., Krogan, N. J., & Harris, R. S. (2013) · Journal of Molecular Biology

HIV Research and TreatmentUbiquitin and proteasome pathways

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Functional analysis of a common BAG3 allele associated with protection from heart failure

Perez-Bermejo, J. A., Judge, L. M., Jensen, C. L., Wu, K., Watry, H. L., Truong, A., Ho, J. J., Carter, M., Runyon, W. V., Kaake, R. M., et al. (2023) · Nature Cardiovascular Research

Heat shock proteins researchCardiac electrophysiology and arrhythmias

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