Ward, Patrick S.

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature

Glioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolism

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Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

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The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab, O., Bennett, B. D., Coller, H. A., Cross, J. R., Fantin, V. R., Hedvat, C. V., Perl, A. E., et al. (2010) · Cancer Cell

Acute Myeloid Leukemia ResearchCancer, Hypoxia, and Metabolism

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

Lu, C., Ward, P. S., Kapoor, G. S., Rohle, D., Turcan, S., Abdel-Wahab, O., Edwards, C. R., Khanin, R., Figueroa, M. E., Melnick, A., et al. (2012) · Nature

Glioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolism

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

Turcan, S., Rohle, D., Goenka, A., Walsh, L. A., Fang, F., Yilmaz, E., Campos, C., Fabius, A. W. M., Lu, C., Ward, P. S., et al. (2012) · Nature

Glioma Diagnosis and TreatmentEpigenetics and DNA Methylation

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MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations

Rath, S., Sharma, R., Gupta, R., Ast, T., Chan, C., Durham, T. J., Goodman, R. P., Grabarek, Z., Haas, M. E., Hung, W. H. W., et al. (2021) · Nucleic Acids Research

Bioinformatics and Genomic NetworksMitochondrial Function and Pathology

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2010) · Nature

Cancer, Hypoxia, and MetabolismMetabolism and Genetic Disorders

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