Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
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Mutations in the d-2-Hydroxyglutarate Dehydrogenase Gene Cause d-2-Hydroxyglutaric Aciduria
Struys, E. A., Salomons, G. S., Achouri, Y., Van Schaftingen, E., Grosso, S., Craigen, W. J., Verhoeven, N. M., & Jakobs, C. (2005) · The American Journal of Human Genetics · doi:10.1086/427890 · Cited by 172 · see citing works
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An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
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- Authors
- Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., Marks, K. M., Prins, R. M., Ward, P. S., Yen, K. E., Liau, L. M., Rabinowitz, J. D., Cantley, L. C., Thompson, C. B., Vander Heiden, M. G., & Su, S. M.
- ORCID
- Venue
- Nature
- Published
- 2010-06
- Volume
- 465
- Issue
- 7300
- Pages
- 966-966
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3766976
- OpenAlex
- W4237937003
- Cited by
- 613
- References
- 1
- Citations by year
- 2026: 27 · 2025: 17 · 2024: 34 · 2023: 45 · 2022: 36 · 2021: 47 · 2020: 40 · 2019: 37 · 2018: 42 · 2017: 41 · 2016: 46 · 2015: 53 · 2014: 33 · 2013: 39 · 2012: 35
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Cancer Institute (R01CA105463)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- IDH1 mutation, 2-hydroxyglutarate, cancer-associated mutations, isocitrate dehydrogenase
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