Manolagas, Stavros C.

Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.

Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 1,753

Matrix-embedded cells control osteoclast formation

Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 1,304

The Pathophysiologic Roles of Interleukin-6 in Human Disease

Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,146

Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin

Plotkin, L. I., Weinstein, R. S., Parfitt, A. M., Roberson, P. K., Manolagas, S. C., & Bellido, T. (1999) · Journal of Clinical Investigation

Bone Metabolism and DiseasesBone health and treatments

Cited by 890

Estrogens and androgens in skeletal physiology and pathophysiology

Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews

Bone health and osteoporosis researchEstrogen and related hormone effects

Cited by 860

Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines

Jilka, R. L., Weinstein, R. S., Bellido, T., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesCell death mechanisms and regulation

Cited by 578

Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.

Aguirre, J. I., Plotkin, L. I., Stewart, S. A., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C., & Bellido, T. (2006) · Journal of Bone and Mineral Research

Spaceflight effects on biologyBone Metabolism and Diseases

Cited by 494

Reversal of Bone Loss in Mice by Nongenotropic Signaling of Sex Steroids

Kousteni, S., Chen, J.-R., Bellido, T., Han, L., Ali, A. A., O'Brien, C. A., Plotkin, L., Fu, Q., Mancino, A. T., Wen, Y., et al. (2002) · Science

Estrogen and related hormone effectsBone health and osteoporosis research

Cited by 420

What old means to bone

Manolagas, S. C., & Parfitt, A. M. (2010) · Trends in Endocrinology & Metabolism

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 404

Glucocorticoids Act Directly on Osteoclasts to Increase Their Life Span and Reduce Bone Density

Jia, D., O’Brien, C. A., Stewart, S. A., Manolagas, S. C., & Weinstein, R. S. (2006) · Endocrinology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 394

Giant Osteoclast Formation and Long-Term Oral Bisphosphonate Therapy

Weinstein, R. S., Roberson, P. K., & Manolagas, S. C. (2009) · New England Journal of Medicine

Bone health and treatmentsBone health and osteoporosis research

Cited by 391

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

Xiong, J., Piemontese, M., Onal, M., Campbell, J., Goellner, J. J., Dusevich, V., Bonewald, L., Manolagas, S. C., & O’Brien, C. A. (2015) · PLOS ONE

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 323

The Estrogen Receptor-α in Osteoclasts Mediates the Protective Effects of Estrogens on Cancellous But Not Cortical Bone

Martin-Millan, M., Almeida, M., Ambrogini, E., Han, L., Zhao, H., Weinstein, R. S., Jilka, R. L., O'Brien, C. A., & Manolagas, S. C. (2010) · Molecular Endocrinology

Bone Metabolism and DiseasesEstrogen and related hormone effects

Cited by 282

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

Onal, M., Piemontese, M., Xiong, J., Wang, Y., Han, L., Ye, S., Komatsu, M., Selig, M., Weinstein, R. S., Zhao, H., et al. (2013) · Journal of Biological Chemistry

Bone Metabolism and DiseasesAutophagy in Disease and Therapy

Cited by 206

DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age

Kim, H., Chang, J., Shao, L., Han, L., Iyer, S., Manolagas, S. C., O'Brien, C. A., Jilka, R. L., Zhou, D., & Almeida, M. (2017) · Aging Cell

Bone Metabolism and DiseasesTelomeres, Telomerase, and Senescence

Cited by 192

Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells.

Mancino, A. T., Klimberg, V. S., Yamamoto, M., Manolagas, S. C., & Abe, E. (2001) · Journal of Surgical Research

Bone Metabolism and DiseasesBone health and treatments

Cited by 138

The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage.

Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1997) · Endocrinology

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 126

PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis

Fujiwara, T., Ye, S., Castro-Gomes, T., Winchell, C. G., Andrews, N. W., Voth, D. E., Varughese, K. I., Mackintosh, S. G., Feng, Y., Pavlos, N., et al. (2016) · JCI Insight

Bone Metabolism and DiseasesCellular transport and secretion

Cited by 92

Steap4 Plays a Critical Role in Osteoclastogenesis in Vitro by Regulating Cellular Iron/Reactive Oxygen Species (ROS) Levels and cAMP Response Element-binding Protein (CREB) Activation

Zhou, J., Ye, S., Fujiwara, T., Manolagas, S. C., & Zhao, H. (2013) · Journal of Biological Chemistry

Bone Metabolism and DiseasesIron Metabolism and Disorders

Cited by 88

Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice

Kim, H., Chang, J., Iyer, S., Han, L., Campisi, J., Manolagas, S. C., Zhou, D., & Almeida, M. (2019) · Aging Cell

Bone Metabolism and DiseasesTelomeres, Telomerase, and Senescence

Cited by 74

Classical Genotropic Versus Kinase-Initiated Regulation of Gene Transcription by the Estrogen Receptor α

Almeida, M., Han, L., O’Brien, C. A., Kousteni, S., & Manolagas, S. C. (2006) · Endocrinology

Estrogen and related hormone effectsBreast Cancer Treatment Studies

Cited by 40