Plemel, Jason R.

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

Faissner, S., Plemel, J. R., Gold, R., & Yong, V. W. (2019) · Nature Reviews Drug Discovery

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 459

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

Zirngibl, M., Assinck, P., Sizov, A., Caprariello, A. V., & Plemel, J. R. (2022) · Molecular Neurodegeneration

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 233

Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy

Plemel, J. R., Michaels, N. J., Weishaupt, N., Caprariello, A. V., Keough, M. B., Rogers, J. A., Yukseloglu, A., Lim, J., Patel, V. V., Rawji, K. S., et al. (2018) · Glia

Multiple Sclerosis Research StudiesSphingolipid Metabolism and Signaling

Cited by 220

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

Plemel, J. R., Stratton, J. A., Michaels, N. J., Rawji, K. S., Zhang, E., Sinha, S., Baaklini, C. S., Dong, Y., Ho, M., Thorburn, K., et al. (2020) · Science Advances

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 208

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Rawji, K. S., Young, A. M. H., Ghosh, T., Michaels, N. J., Mirzaei, R., Kappen, J., Kolehmainen, K. L., Alaeiilkhchi, N., Lozinski, B., Mishra, M. K., et al. (2020) · Acta Neuropathologica

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 153

Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury

Assinck, P., Duncan, G. J., Plemel, J. R., Lee, M. J., Stratton, J. A., Manesh, S. B., Liu, J., Ramer, L. M., Kang, S. H., Bergles, D. E., et al. (2017) · The Journal of Neuroscience

Spinal Cord Injury ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 151

The molecular physiology of the axo-myelinic synapse

Micu, I., Plemel, J. R., Lachance, C., Proft, J., Jansen, A. J., Cummins, K., van Minnen, J., & Stys, P. K. (2016) · Experimental Neurology

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 140

Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

Duncan, G. J., Manesh, S. B., Hilton, B. J., Assinck, P., Liu, J., Moulson, A., Plemel, J. R., & Tetzlaff, W. (2018) · Nature Communications

Spinal Cord Injury ResearchNerve injury and regeneration

Cited by 113

Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression

Plemel, J. R., Manesh, S. B., Sparling, J. S., & Tetzlaff, W. (2013) · Glia

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 107

Biochemically altered myelin triggers autoimmune demyelination

Caprariello, A. V., Rogers, J. A., Morgan, M. L., Hoghooghi, V., Plemel, J. R., Koebel, A., Tsutsui, S., Dunn, J. F., Kotra, L. P., Ousman, S. S., et al. (2018) · Proceedings of the National Academy of Sciences

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 104

Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis

Plemel, J. R., Caprariello, A. V., Keough, M. B., Henry, T. J., Tsutsui, S., Chu, T. H., Schenk, G. J., Klaver, R., Yong, V. W., & Stys, P. K. (2017) · Journal of Cell Biology

Cell death mechanisms and regulationAdvanced Fluorescence Microscopy Techniques

Cited by 97

Microglia promote remyelination independent of their role in clearing myelin debris

Baaklini, C. S., Ho, M. F. S., Lange, T., Hammond, B. P., Panda, S. P., Zirngibl, M., Zia, S., Himmelsbach, K., Rana, H., Phillips, B., et al. (2023) · Cell Reports

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 73

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Gross, P. S., Durán-Laforet, V., Ho, L. T., Melchor, G. S., Zia, S., Manavi, Z., Barclay, W. E., Lee, S. H., Shults, N., Selva, S., et al. (2025) · Nature Communications

Multiple Sclerosis Research StudiesTelomeres, Telomerase, and Senescence

Cited by 62

Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance

Zia, S., Hammond, B. P., Zirngibl, M., Sizov, A., Baaklini, C. S., Panda, S. P., Ho, M. F. S., Lee, K. V., Mainali, A., Burr, M. K., et al. (2022) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 40

Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis

Pollock, N. M., Fernandes, J. P., Woodfield, J., Moussa, E., Hlavay, B., Branton, W. G., Wuest, M., Mohammadzadeh, N., Schmitt, L., Plemel, J. R., et al. (2024) · Brain, Behavior, and Immunity

Multiple Sclerosis Research StudiesInflammasome and immune disorders

Cited by 21