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Cited by 113Spinal Cord Injury ResearchNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

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Duncan, Greg J., Manesh, Sohrab B., Hilton, Brett J., Assinck, Peggy, Liu, Jie, Moulson, Aaron, Plemel, Jason R., Tetzlaff, Wolfram·2018·Nature Communications
DOI 10.1038/s41467-018-05473-1PMC PMC6076268
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Abstract

Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor ( Myrf ) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor cells (OPCs) in mice prior to SCI. While OPC proliferation and density are not altered by Myrf inducible knockout after SCI, the accumulation of new oligodendrocytes is largely prevented. This greatly inhibits myelin regeneration, resulting in a 44% reduction in myelinated axons at the lesion epicenter. However, spontaneous locomotor recovery after SCI is not altered by remyelination failure. In controls with functional MYRF, locomotor recovery precedes the onset of most oligodendrocyte myelin regeneration. Collectively, these data demonstrate that MYRF expression in PDGFRα-positive cell derived oligodendrocytes is indispensable for myelin regeneration following contusive SCI but that oligodendrocyte remyelination is not required for spontaneous recovery of stepping.

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Authors
Duncan, G. J., Manesh, S. B., Hilton, B. J., Assinck, P., Liu, J., Moulson, A., Plemel, J. R., & Tetzlaff, W.
Affiliations
  • University of British Columbia (CA)
  • University of Calgary (CA)
Corresponding author
Tetzlaff, Wolfram
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2018-08-03
Volume
9
Issue
1
Pages
3066-3066
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-018-05473-1
PMC
PMC6076268
OpenAlex
W2886051951
Cited by
113
References
7
Citations by year
2026: 9 · 2025: 15 · 2024: 8 · 2023: 15 · 2022: 19 · 2021: 15 · 2020: 21 · 2019: 10 · 2017: 1
FWCI
8.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • DZNE Pub (submittedVersion, cc-by)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders
Gouvernement du Canada | Canadian Institutes of Health Research (MOP-130475)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
spinal cord injury, contusive injury, remyelination, oligodendrocytes, MYRF, oligodendrocyte precursor cells, PDGFRA, locomotor recovery, myelinated axons, gene knockout
MeSH terms
Remyelination, Animals, Axons, Behavior, Animal, Cell Differentiation, Disease Models, Animal, Female, Male, Myelin Sheath, Nerve Regeneration, Oligodendroglia, Spinal Cord, Spinal Cord Injuries, Transcription Factors, Gene Deletion, Mice, Knockout, Receptor, Platelet-Derived Growth Factor alpha, Cell Proliferation, Mice, Neural Stem Cells

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