Yokoyama, Shigeyuki

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature

Adipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Cited by 757

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

Padmanabhan, B., Tong, K. I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.-I., Kobayashi, A., Yokoyama, S., & Yamamoto, M. (2006) · Molecular Cell

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 735

Role of the ENTH Domain in Phosphatidylinositol-4,5-Bisphosphate Binding and Endocytosis

Itoh, T., Koshiba, S., Kigawa, T., Kikuchi, A., Yokoyama, S., & Takenawa, T. (2001) · Science

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 469

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

Verba, K. A., Wang, R. Y.-R., Arakawa, A., Liu, Y., Shirouzu, M., Yokoyama, S., & Agard, D. A. (2016) · Science

Heat shock proteins researchProtein Structure and Dynamics

Cited by 424

Molecular mechanism of codon recognition by tRNA species with modified uridine in the first position of the anticodon.

Yokoyama, S., Watanabe, T., Murao, K., Ishikura, H., Yamaizumi, Z., Nishimura, S., & Miyazawa, T. (1985) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Cited by 271

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

Harada, Y., Tanaka, Y., Terasawa, M., Pieczyk, M., Habiro, K., Katakai, T., Hanawa-Suetsugu, K., Kukimoto-Niino, M., Nishizaki, T., Shirouzu, M., et al. (2012) · Blood

Immunodeficiency and Autoimmune DisordersImmunotherapy and Immune Responses

Cited by 236

A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling

HATAKEYAMA, M., KIMURA, S., NAKA, T., KAWASAKI, T., YUMOTO, N., ICHIKAWA, M., KIM, J.-H., SAITO, K., SAEKI, M., SHIROUZU, M., et al. (2003) · Biochemical Journal

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 233

FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure

Hino, S., Sakamoto, A., Nagaoka, K., Anan, K., Wang, Y., Mimasu, S., Umehara, T., Yokoyama, S., Kosai, K.-I., & Nakao, M. (2012) · Nature Communications

Epigenetics and DNA MethylationAdipose Tissue and Metabolism

Cited by 226

Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor

Yoshikawa, S., Kukimoto-Niino, M., Parker, L., Handa, N., Terada, T., Fujimoto, T., Terazawa, Y., Wakiyama, M., Sato, M., Sano, S., et al. (2013) · Oncogene

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 138

Multiple Post-translational Modifications Affect Heterologous Protein Synthesis

Tokmakov, A. A., Kurotani, A., Takagi, T., Toyama, M., Shirouzu, M., Fukami, Y., & Yokoyama, S. (2012) · Journal of Biological Chemistry

Protein purification and stabilityRNA and protein synthesis mechanisms

Cited by 88

Immune regulatory functions of DOCK family proteins in health and disease

Nishikimi, A., Kukimoto-Niino, M., Yokoyama, S., & Fukui, Y. (2013) · Experimental Cell Research

Protein Kinase Regulation and GTPase SignalingImmunodeficiency and Autoimmune Disorders

Cited by 80

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

Hanawa-Suetsugu, K., Kukimoto-Niino, M., Mishima-Tsumagari, C., Akasaka, R., Ohsawa, N., Sekine, S.-I., Ito, T., Tochio, N., Koshiba, S., Kigawa, T., et al. (2012) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 70

Differential Structural Requirements for Interaction of Ras Protein with Its Distinct Downstream Effectors

Akasaka, K., Tamada, M., Wang, F., Kariya, K.-I., Shima, F., Kikuchi, A., Yamamoto, M., Shirouzu, M., Yokoyama, S., & Kataoka, T. (1996) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 69

Polyamines protect nucleic acids against depurination

Terui, Y., Yoshida, T., Sakamoto, A., Saito, D., Oshima, T., Kawazoe, M., Yokoyama, S., Igarashi, K., & Kashiwagi, K. (2018) · The International Journal of Biochemistry & Cell Biology

Polyamine Metabolism and ApplicationsDNA and Nucleic Acid Chemistry

Cited by 44

Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha‐4,11‐diene

Komori, A., Suzuki, M., Seki, H., Nishizawa, T., Meyer, J. J. M., Shimizu, H., Yokoyama, S., & Muranaka, T. (2013) · FEBS Letters

Plant biochemistry and biosynthesisSesquiterpenes and Asteraceae Studies

Cited by 24