Shulman, Gerald I.

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

Fernández, A. M., Kim, J. K., Yakar, S., Dupont, J., Hernandez-Sanchez, C., Castle, A. L., Filmore, J., Shulman, G. I., & Le Roith, D. (2001) · Genes & Development

Metabolism, Diabetes, and CancerGrowth Hormone and Insulin-like Growth Factors

Cited by 369

Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study

Perseghin, G., Ghosh, S., Gerow, K., & Shulman, G. I. (1997) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 367

Regulation of Adipose Tissue Inflammation by Interleukin 6

Han, M. S., White, A., Perry, R. J., Camporez, J.-P., Hidalgo, J., Shulman, G. I., & Davis, R. J. (2020) · Proceedings of the National Academy of Sciences

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 344

Skeletal muscle lipid metabolism with obesity

Hulver, M. W., Berggren, J. R., Cortright, R. N., Dudek, R. W., Thompson, R. P., Pories, W. J., MacDonald, K. G., Cline, G. W., Shulman, G. I., Dohm, G. L., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism

Adipose Tissue and MetabolismLipid metabolism and biosynthesis

Cited by 339

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., et al. (2012) · Nature Medicine

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 335

Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk

Handschin, C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Mootha, V. K., Kim, Y.-B., et al. (2007) · Journal of Clinical Investigation

Pancreatic function and diabetesAdipose Tissue and Metabolism

Cited by 335

Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

Kim, J. K., Michael, M. D., Previs, S. F., Peroni, O. D., Mauvais-Jarvis, F., Neschen, S., Kahn, B. B., Kahn, C. R., & Shulman, G. I. (2000) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

Cited by 331

Decreased Muscle Glucose-Transport Phosphorylation Is an Early Defect in the Pathogenesis of Non-Insulin-Dependent Diabetes-Mellitus

Rothman, D. L., Magnusson, I., Cline, G., Gerard, D., Kahn, C. R., Shulman, R. G., & Shulman, G. I. (1995) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 325

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Choi, C. S., Savage, D. B., Abu-Elheiga, L., Liu, Z.-X., Kim, S., Kulkarni, A., Distefano, A., Hwang, Y.-J., Reznick, R. M., Codella, R., et al. (2007) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 325

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance

Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 319

Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes.

Krssak, M., Brehm, A., Bernroider, E., Anderwald, C., Nowotny, P., Man, C. D., Cobelli, C., Cline, G. W., Shulman, G. I., Waldhäusl, W., et al. (2004) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

Cited by 313

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents

Petersen, K. F., Dufour, S., & Shulman, G. I. (2005) · PLoS Medicine

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 308

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

Danial, N. N., Walensky, L. D., Zhang, C.-Y., Choi, C. S., Fisher, J. K., Molina, A. J. A., Datta, S. R., Pitter, K. L., Bird, G. H., Wikstrom, J. D., et al. (2008) · Nature Medicine

Pancreatic function and diabetesCell death mechanisms and regulation

Cited by 307

Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo

Previs, S. F., Withers, D. J., Ren, J.-M., White, M. F., & Shulman, G. I. (2000) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 291

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Zhang, D., Liu, Z.-X., Choi, C. S., Tian, L., Kibbey, R., Dong, J., Cline, G. W., Wood, P. A., & Shulman, G. I. (2007) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerLiver Disease Diagnosis and Treatment

Cited by 291

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans

Roden, M., Stingl, H., Chandramouli, V, Schumann, W. C., Hofer, A., Landau, B. R., Nowotny, P., Waldhäusl, W., & Shulman, G. I. (2000) · Diabetes

Pancreatic function and diabetesDiet, Metabolism, and Disease

Cited by 288

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

Tao, H., Zhang, Y., Zeng, X., Shulman, G. I., & Jin, S. (2014) · Nature Medicine

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 288

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

Perry, R. J., Zhang, D., Zhang, X.-M., Boyer, J. L., & Shulman, G. I. (2015) · Science

Liver Disease Diagnosis and TreatmentMetabolism, Diabetes, and Cancer

Cited by 283

Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

Choi, C. S., Befroy, D. E., Codella, R., Kim, S., Reznick, R. M., Hwang, Y.-J., Liu, Z.-X., Lee, H.-Y., Distefano, A., Samuel, V. T., et al. (2008) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 279

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

Neschen, S., Morino, K., Hammond, L. E., Zhang, D., Liu, Z.-X., Romanelli, A. J., Cline, G. W., Pongratz, R. L., Zhang, X.-M., Choi, C. S., et al. (2005) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 261

Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.

Taylor, R., Magnusson, I., Rothman, D. L., Cline, G. W., Caumo, A., Cobelli, C., & Shulman, G. I. (1996) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerDiet, Metabolism, and Disease

Cited by 258

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

Ferris, H. A., Perry, R. J., Moreira, G. V., Shulman, G. I., Horton, J. D., & Kahn, C. R. (2017) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 246

Lacteal junction zippering protects against diet-induced obesity

Zhang, F., Zarkada, G., Han, J., Li, J., Dubrac, A., Ola, R., Genet, G., Boyé, K., Michon, P., Künzel, S. E., et al. (2018) · Science

Lymphatic System and DiseasesLymphatic Disorders and Treatments

Cited by 237

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids

Vatner, D. F., Majumdar, S. K., Kumashiro, N., Petersen, M. C., Rahimi, Y., Gattu, A. K., Bears, M., Camporez, J.-P. G., Cline, G. W., Jurczak, M. J., et al. (2015) · Proceedings of the National Academy of Sciences

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 235