Shulman, Gerald I.

The integrative biology of type 2 diabetes

Roden, M., & Shulman, G. I. (2019) · Nature

Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

Cited by 1,167

Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,162

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

Shulman, G. I. (2014) · New England Journal of Medicine

Cardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 1,126

Regulation of mitochondrial biogenesis

Jornayvaz, F. R., & Shulman, G. I. (2010) · Essays in Biochemistry

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 1,119

Disordered lipid metabolism and the pathogenesis of insulin resistance.

Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews

Diabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

Cited by 1,107

Mechanism by which metformin reduces glucose production in type 2 diabetes.

Hundal, R. S., Krssak, M., Dufour, S., Laurent, D., Lebon, V, Chandramouli, V, Inzucchi, S. E., Schumann, W. C., Petersen, K. F., Landau, B. R., et al. (2000) · Diabetes

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 1,052

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

Zong, H., Ren, J. M., Young, L. H., Pypaert, M., Mu, J., Birnbaum, M. J., & Shulman, G. I. (2002) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 1,036

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 917

Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsLiver Disease Diagnosis and Treatment

Cited by 911

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

Morino, K., Petersen, K. F., & Shulman, G. I. (2006) · Diabetes

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 853

Etiology of Insulin Resistance

Petersen, K. F., & Shulman, G. I. (2006) · The American Journal of Medicine

Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

Cited by 825

A guide to analysis of mouse energy metabolism

Tschöp, M. H., Speakman, J. R., Arch, J. R. S., Auwerx, J., Brüning, J. C., Chan, L., Eckel, R. H., Farese, R. V., Galgani, J. E., Hambly, C., et al. (2012) · Nature Methods

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 813

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

Petersen, K. F., Oral, E. A., Dufour, S., Befroy, D., Ariyan, C., Yu, C., Cline, G. W., DePaoli, A. M., Taylor, S. I., Gorden, P., et al. (2002) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 800

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

Inzucchi, S. E., Maggs, D. G., Spollett, G. R., Page, S. L., Rife, F. S., Walton, V., & Shulman, G. I. (1998) · New England Journal of Medicine

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 794

Cellular and Molecular Mechanisms of Metformin Action

LaMoia, T. E., & Shulman, G. I. (2021) · Endocrine Reviews

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 791

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences

Diabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Cited by 759

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

Magnusson, I., Rothman, D. L., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1992) · Journal of Clinical Investigation

Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 757

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences

Lipid metabolism and disordersMetabolism, Diabetes, and Cancer

Cited by 753

Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases

Samuel, V. T., & Shulman, G. I. (2018) · Cell Metabolism

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 745

Prevention of fat-induced insulin resistance by salicylate

Kim, J. K., Kim, Y.-J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., et al. (2001) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 737

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

Perry, R. J., Camporez, J.-P. G., Kursawe, R., Titchenell, P. M., Zhang, D., Perry, C. J., Jurczak, M. J., Abudukadier, A., Han, M. S., Zhang, X.-M., et al. (2015) · Cell

Adipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

Cited by 719

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

Andrews, Z. B., Liu, Z.-W., Walllingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschöp, M. H., Shanabrough, M., Cline, G., Shulman, G. I., et al. (2008) · Nature

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 710

Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects

Perseghin, G., Price, T. B., Petersen, K. F., Roden, M., Cline, G. W., Gerow, K., Rothman, D. L., & Shulman, G. I. (1996) · New England Journal of Medicine

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 699

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, O., Marcus-Samuels, B., Graham, D., Kim, J. K., Shulman, G. I., Castle, A. L., Vinson, C., Eckhaus, M., & Reitman, M. L. (2000) · Journal of Clinical Investigation

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 676