Lock, Richard

The pediatric preclinical testing program: Description of models and early testing results

Houghton, P. J., Morton, C. L., Tucker, C., Payne, D., Favours, E., Cole, C., Gorlick, R., Kolb, E. A., Zhang, W., Lock, R., et al. (2007) · Pediatric Blood & Cancer

Acute Lymphoblastic Leukemia researchSarcoma Diagnosis and Treatment

Cited by 480

Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis

Murphy, B., Yin, H., Maris, J. M., Kolb, E. A., Gorlick, R., Reynolds, C. P., Kang, M. H., Keir, S. T., Kurmasheva, R. T., Dvorchik, I., et al. (2016) · Cancer Research

Animal testing and alternativesCancer Cells and Metastasis

Cited by 69

Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex

Piazza, R., Magistroni, V., Mogavero, A., Andreoni, F., Ambrogio, C., Chiarle, R., Mologni, L., Bachmann, P. S., Lock, R. B., Collini, P., et al. (2013) · Neoplasia

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 51

Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture

Chen, N., Eritja, N., Lock, R., & Debnath, J. (2013) · Oncogene

Autophagy in Disease and TherapyPI3K/AKT/mTOR signaling in cancer

Cited by 50

Initial Testing (Stage 1) of MK‐8242—A Novel MDM2 Inhibitor—by the Pediatric Preclinical Testing Program

Kang, M. H., Reynolds, C. P., Kolb, E. A., Gorlick, R., Carol, H., Lock, R., Keir, S. T., Maris, J. M., Wu, J., Lyalin, D., et al. (2016) · Pediatric Blood & Cancer

Cancer-related Molecular PathwaysCancer Mechanisms and Therapy

Cited by 36

Initial testing of JNJ‐26854165 (Serdemetan) by the pediatric preclinical testing program

Smith, M. A., Gorlick, R., Kolb, E. A., Lock, R., Carol, H., Maris, J. M., Keir, S. T., Morton, C. L., Reynolds, C. P., Kang, M. H., et al. (2012) · Pediatric Blood & Cancer

Cancer-related Molecular PathwaysAcute Lymphoblastic Leukemia research

Cited by 26

PU.1 Eviction at Lymphocyte-Specific Chromatin Domains Mediates Glucocorticoid Response in Acute Lymphoblastic Leukemia

Jing, D., Beck, D., Cao, H., Tian, F., Huang, Y., Zhao, H., Tai, X., XU, W., Kosasih, H., Kealy, D., et al. (2024) · Nature Communications

Acute Lymphoblastic Leukemia researchGenomics and Chromatin Dynamics

Cited by 9

PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia

Beck, D., Cao, H., Tian, F., Huang, Y., Jiang, M., Zhao, H., Tai, X., Xu, W., Kosasih, H. J., Kealy, D. J., et al. (2024) · Nature Communications

Acute Lymphoblastic Leukemia researchGenomics and Chromatin Dynamics

Cited by 9