Bernards, René

CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma

Wang, C., Wang, H., Lieftink, C., du Chatinier, A., Gao, D., Jin, G., Jin, H., Beijersbergen, R. L., Qin, W., & Bernards, R. (2020) · Gut

Hepatocellular Carcinoma Treatment and PrognosisCancer-related Molecular Pathways

Cited by 107

Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer

van Geel, R. M. J. M., van Brummelen, E. M. J., Eskens, F. A. L. M., Huijberts, S. C. F. A., de Vos, F. Y. F. L., Lolkema, M. P. J. K., Devriese, L. A., Opdam, F. L., Marchetti, S., Steeghs, N., et al. (2020) · British Journal of Cancer

Melanoma and MAPK PathwaysColorectal Cancer Treatments and Studies

Cited by 55

A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

Šuštić, T., van Wageningen, S., Bosdriesz, E., Reid, R. J. D., Dittmar, J., Lieftink, C., Beijersbergen, R. L., Wessels, L. F. A., Rothstein, R., & Bernards, R. (2018) · Genome Medicine

Melanoma and MAPK PathwaysEndoplasmic Reticulum Stress and Disease

Cited by 42

A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors

Ruiz-Saenz, A., Atreya, C. E., Wang, C., Pan, B., Dreyer, C. A., Brunen, D., Prahallad, A., Muñoz, D. P., Ramms, D. J., Burghi, V., et al. (2023) · Nature Cancer

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

Cited by 39

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery

Peeper, D. S., & Bernards, R. (1997) · FEBS Letters

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 36

A system-wide approach to monitor responses to synergistic BRAF and EGFR inhibition in colorectal cancer cells

Ressa, A., Bosdriesz, E., de Ligt, J., Mainardi, S., Maddalo, G., Prahallad, A., Jager, M., de la Fonteijne, L., Fitzpatrick, M., Groten, S., et al. (2018) · Molecular & Cellular Proteomics

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

Cited by 17