Bernards, René

Gene expression profiling predicts clinical outcome of breast cancer

van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature

Breast Cancer Treatment StudiesGene expression and cancer classification

Cited by 9,536

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

Prahallad, A., Sun, C., Huang, S., Di Nicolantonio, F., Salazar, R., Zecchin, D., Beijersbergen, R. L., Bardelli, A., & Bernards, R. (2012) · Nature

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

Cited by 2,051

A genomic and functional inventory of deubiquitinating enzymes.

Nijman, S. M. B., Luna-Vargas, M. P. A., Velds, A., Brummelkamp, T. R., Dirac, A. M. G., Sixma, T. K., & Bernards, R. (2005) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 1,854

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

Berns, K., Horlings, H. M., Hennessy, B. T., Madiredjo, M., Hijmans, E. M., Beelen, K., Linn, S. C., Gonzalez-Angulo, A. M., Stemke-Hale, K., Hauptmann, M., et al. (2007) · Cancer Cell

PI3K/AKT/mTOR signaling in cancerHER2/EGFR in Cancer Research

Cited by 1,627

Exploiting senescence for the treatment of cancer

Wang, L., Lankhorst, L., & Bernards, R. (2022) · Nature Reviews Cancer

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 867

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

Zwijsen, R. M. L., Wientjens, E., Klompmaker, R., van der Sman, J., Bernards, R., & Michalides, R. J. A. M. (1997) · Cell

Estrogen and related hormone effectsCancer-related Molecular Pathways

Cited by 720

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

Kortlever, R. M., Higgins, P. J., & Bernards, R. (2006) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 637

Protein phosphatase 2A regulatory subunits and cancer

Eichhorn, P. J. A., Creyghton, M. P., & Bernards, R. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 513

Rational combinations of targeted cancer therapies: background, advances and challenges

Jin, H., Wang, L., & Bernards, R. (2023) · Nature Reviews Drug Discovery

Lung Cancer Treatments and MutationsCancer Genomics and Diagnostics

Cited by 503

The Human Tumor Antigen PRAME Is a Dominant Repressor of Retinoic Acid Receptor Signaling

Epping, M. T., Wang, L., Edel, M. J., Carlée, L., Hernandez, M., & Bernards, R. (2005) · Cell

Retinoids in leukemia and cellular processesEpigenetics and DNA Methylation

Cited by 432

MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

Huang, S., Hölzel, M., Knijnenburg, T., Schlicker, A., Roepman, P., McDermott, U., Garnett, M., Grernrum, W., Sun, C., Prahallad, A., et al. (2012) · Cell

TGF-β signaling in diseasesLung Cancer Treatments and Mutations

Cited by 430

Inducing and exploiting vulnerabilities for the treatment of liver cancer

Wang, C., Vegna, S., Jin, H., Benedict, B., Lieftink, C., Ramirez, C., de Oliveira, R. L., Morris, B., Gadiot, J., Wang, W., et al. (2019) · Nature

Telomeres, Telomerase, and SenescenceHepatocellular Carcinoma Treatment and Prognosis

Cited by 427

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Verissimo, C. S., Overmeer, R. M., Ponsioen, B., Drost, J., Mertens, S., Verlaan-Klink, I., Gerwen, B. V., van der Ven, M., Wetering, M. V. D., Egan, D. A., et al. (2016) · eLife

Colorectal Cancer Treatments and StudiesProtein Kinase Regulation and GTPase Signaling

Cited by 263

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

Wang, L., Leite de Oliveira, R., Wang, C., Fernandes Neto, J. M., Mainardi, S., Evers, B., Lieftink, C., Morris, B., Jochems, F., Willemsen, L., et al. (2017) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 224

The Cancer SENESCopedia: A delineation of cancer cell senescence

Jochems, F., Thijssen, B., De Conti, G., Jansen, R., Pogacar, Z., Groot, K., Wang, L., Schepers, A., Wang, C., Jin, H., et al. (2021) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 201

Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies

Sun, C., & Bernards, R. (2014) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingHER2/EGFR in Cancer Research

Cited by 155

TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 and Inhibits Senescence

Brummelkamp, T. R., Kortlever, R. M., Lingbeek, M., Trettel, F., MacDonald, M. E., van Lohuizen, M., & Bernards, R. (2002) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 154

Genome-wide Loss-of-Function Screen Reveals an Important Role for the Proteasome in HDAC Inhibitor-Induced Apoptosis

Fotheringham, S., Epping, M. T., Stimson, L., Khan, O., Wood, V., Pezzella, F., Bernards, R., & La Thangue, N. B. (2009) · Cancer Cell

Histone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathways

Cited by 138

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF -Mutant Colorectal Cancer

Oddo, D., Sennott, E. M., Barault, L., Valtorta, E., Arena, S., Cassingena, A., Filiciotto, G., Marzolla, G., Elez, E., van Geel, R. M. J. M., et al. (2016) · Cancer Research

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

Cited by 121

E2F transcriptional repressor complexes are critical downstream targets of p19ARF/p53-induced proliferative arrest

Rowland, B. D., Denissov, S. G., Douma, S., Stunnenberg, H. G., Bernards, R., & Peeper, D. S. (2002) · Cancer Cell

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 120

TSPYL5 suppresses p53 levels and function by physical interaction with USP7.

Epping, M. T., Meijer, L. A. T., Krijgsman, O., Bos, J. L., Pandolfi, P. P., & Bernards, R. (2011) · Nature Cell Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 117

New tools for functional mammalian cancer genetics

Brummelkamp, T. R., & Bernards, R. (2003) · Nature Reviews Cancer

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 114

Fighting Drug Resistance through the Targeting of Drug-Tolerant Persister Cells

De Conti, G., Dias, M. H., & Bernards, R. (2021) · Cancers

Cancer Cells and MetastasisCell death mechanisms and regulation

Cited by 111

Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells

Nicke, B., Bastien, J., Khanna, S. J., Warne, P. H., Cowling, V., Cook, S. J., Peters, G., Delpuech, O., Schulze, A., Berns, K., et al. (2005) · Molecular Cell

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 108