Shokhirev, Maxim N.

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

Konermann, S., Lotfy, P., Brideau, N. J., Oki, J., Shokhirev, M. N., & Hsu, P. D. (2018) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,164

The aging astrocyte transcriptome from multiple regions of the mouse brain.

Boisvert, M. M., Erikson, G. A., Shokhirev, M. N., & Allen, N. J. (2018) · Cell Reports

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 702

Glioblastoma Model Using Human Cerebral Organoids

Ogawa, J., Pao, G. M., Shokhirev, M. N., & Verma, I. M. (2018) · Cell Reports

Glioma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 391

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

Vinogradova, E. V., Zhang, X., Remillard, D., Lazar, D. C., Suciu, R. M., Wang, Y., Bianco, G., Yamashita, Y., Crowley, V. M., Schafroth, M. A., et al. (2020) · Cell

Redox biology and oxidative stressGenomics, phytochemicals, and oxidative stress

Cited by 351

Predicting age from the transcriptome of human dermal fibroblasts

Fleischer, J. G., Schulte, R., Tsai, H. H., Tyagi, S., Ibarra, A., Shokhirev, M. N., Huang, L., Hetzer, M. W., & Navlakha, S. (2018) · Genome Biology

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 232

Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen

Sanchez, K. K., Chen, G. Y., Schieber, A. M. P., Redford, S. E., Shokhirev, M. N., Leblanc, M., Lee, Y. M., & Ayres, J. S. (2018) · Cell

Escherichia coli research studiesGut microbiota and health

Cited by 175

The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC

Hollstein, P. E., Eichner, L. J., Brun, S. N., Kamireddy, A., Svensson, R. U., Vera, L. I., Ross, D. S., Rymoff, T. J., Hutchins, A., Galvez, H. M., et al. (2019) · Cancer Discovery

Metabolism, Diabetes, and CancerHippo pathway signaling and YAP/TAZ

Cited by 168

Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age

Johnson, A. A., Shokhirev, M. N., Wyss-Coray, T., & Lehallier, B. (2020) · Ageing Research Reviews

Genetics, Aging, and Longevity in Model OrganismsAdvanced Proteomics Techniques and Applications

Cited by 166

An RNA polymerase ribozyme that synthesizes its own ancestor

Tjhung, K. F., Shokhirev, M. N., Horning, D. P., & Joyce, G. F. (2020) · Proceedings of the National Academy of Sciences

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 121

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

Van Nostrand, J. L., Hellberg, K., Luo, E.-C., Van Nostrand, E. L., Dayn, A., Yu, J., Shokhirev, M. N., Dayn, Y., Yeo, G. W., & Shaw, R. J. (2020) · Genes & Development

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 111

Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging

Lehallier, B., Shokhirev, M. N., Wyss‐Coray, T., & Johnson, A. A. (2020) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 106

Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders.

Caldwell, A. L. M., Sancho, L., Deng, J., Bosworth, A., Miglietta, A., Diedrich, J. K., Shokhirev, M. N., & Allen, N. J. (2022) · Nature Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 86

An integrative machine-learning meta-analysis of high-throughput omics data identifies age-specific hallmarks of Alzheimer’s disease

Shokhirev, M. N., & Johnson, A. A. (2022) · Ageing Research Reviews

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 42

Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes

Schwartz, R. E., Shokhirev, M. N., Andrade, L. R., Gutkind, J. S., Iglesias-Bartolome, R., & Shadel, G. S. (2021) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 23

The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets

Johnson, A. A., Shokhirev, M. N., & Lehallier, B. (2021) · Ageing Research Reviews

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 22

A neurogenetic mechanism of experience-dependent suppression of aggression

Ishii, K., Cortese, M., Leng, X., Shokhirev, M. N., & Asahina, K. (2022) · Science Advances

Neurobiology and Insect Physiology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 16