Kramann, Rafael

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell

Mesenchymal stem cell researchLiver physiology and pathology

Cited by 922

Spatial multi-omic map of human myocardial infarction

Kuppe, C., Ramirez Flores, R. O., Li, Z., Hayat, S., Levinson, R. T., Liao, X., Hannani, M. T., Tanevski, J., Wünnemann, F., Nagai, J. S., et al. (2022) · Nature

Single-cell and spatial transcriptomicsCongenital heart defects research

Cited by 772

Decoding myofibroblast origins in human kidney fibrosis

Kuppe, C., Ibrahim, M. M., Kranz, J., Zhang, X., Ziegler, S., Perales-Patón, J., Jansen, J., Reimer, K. C., Smith, J. R., Dobie, R., et al. (2021) · Nature

Chronic Kidney Disease and DiabetesAcute Kidney Injury Research

Cited by 769

Differentiated kidney epithelial cells repair injured proximal tubule

Kusaba, T., Lalli, M., Kramann, R., Kobayashi, A., & Humphreys, B. D. (2014) · Proceedings of the National Academy of Sciences

Acute Kidney Injury ResearchRenal and related cancers

Cited by 476

Mesenchymal stem cells in fibrotic disease

El Agha, E., Kramann, R., Schneider, R. K., Li, X., Seeger, W., Humphreys, B. D., & Bellusci, S. (2017) · Cell stem cell

Mesenchymal stem cell researchTGF-β signaling in diseases

Cited by 430

Targeting immune–fibroblast cell communication in heart failure

Amrute, J. M., Luo, X., Penna, V., Yang, S., Yamawaki, T., Hayat, S., Bredemeyer, A., Jung, I.-H., Kadyrov, F. F., Heo, G. S., et al. (2024) · Nature

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 339

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

Zewinger, S., Reiser, J., Jankowski, V., Alansary, D., Hahm, E., Triem, S., Klug, M., Schunk, S. J., Schmit, D., Kramann, R., et al. (2020) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 280

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Jansen, J., Reimer, K. C., Nagai, J. S., Varghese, F. S., Overheul, G. J., de Beer, M., Roverts, R., Daviran, D., Fermin, L. A. S., Willemsen, B., et al. (2022) · Cell Stem Cell

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 259

Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS

Schneider, R. K., Ademà, V., Heckl, D., Järås, M., Mallo, M., Lord, A. M., Chu, L. P., McConkey, M. E., Kramann, R., Mullally, A., et al. (2014) · Cancer Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 188

Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses

Dugourd, A., Kuppe, C., Sciacovelli, M., Gjerga, E., Gabor, A., Emdal, K. B., Vieira, V., Bekker‐Jensen, D. B., Kranz, J., Bindels, E. M. J., et al. (2021) · Molecular Systems Biology

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 149

Defining cardiac functional recovery in end-stage heart failure at single-cell resolution

Amrute, J. M., Lai, L., Ma, P., Koenig, A. L., Kamimoto, K., Bredemeyer, A., Shankar, T. S., Kuppe, C., Kadyrov, F. F., Schulte, L. J., et al. (2023) · Nature Cardiovascular Research

Cardiac Fibrosis and RemodelingMechanical Circulatory Support Devices

Cited by 79

The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis

Kramann, R., & Schneider, R. K. (2018) · Blood

Myeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia Research

Cited by 62

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

Ribezzo, F., Snoeren, I. A. M., Ziegler, S., Stoelben, J., Olofsen, P. A., Henic, A., Ferreira, M. V., Chen, S., Stalmann, U. S. A., Buesche, G., et al. (2019) · Leukemia

Acute Myeloid Leukemia ResearchBlood disorders and treatments

Cited by 51

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target

Schneider, R. K., Mullally, A., Dugourd, A., Peisker, F., Hoogenboezem, R., Van Strien, P. M. H., Bindels, E. M., Heckl, D., Büsche, G., Fleck, D., et al. (2018) · Cell Stem Cell

Myeloproliferative Neoplasms: Diagnosis and TreatmentMesenchymal stem cell research

Cited by 34

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis

Gleitz, H. F., Kramann, R., & Schneider, R. K. (2018) · The Journal of Pathology

Myeloproliferative Neoplasms: Diagnosis and TreatmentHematopoietic Stem Cell Transplantation

Cited by 23

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

Amrute, J. M., Luo, X., Penna, V., Bredemeyer, A., Yamawaki, T., Heo, G. S., Shi, S., Koenig, A., Yang, S., Kadyrov, F., et al. (2022) · bioRxiv

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 14

Defining Cardiac Recovery at Single Cell Resolution

Amrute, J. M., Lai, L., Ma, P., Koenig, A. L., Kamimoto, K., Bredemeyer, A., Shankar, T. S., Kuppe, C., Kadyrov, F. F., Schulte, L. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory)

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 6

Label-free single-cell RNA multiplexing leveraging genetic variability

Hoeft, K., Bleckwehl, T., Schumacher, D., Kim, H., Meyer, R., Long, Q., Zhang, L., Möller, C., Clahsen-van Groningen, M. C., Babler, A., et al. (2024) · Nature Communications

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 3

Individualised treatment effects of corticosteroids in IgA nephropathy

Hölscher, D. L., Schmitz, N. E. J., Niggemeier, L., Pilva, P., Strauch, M., Tesar, V., Barratt, J., Roberts, I. S. D., Coppo, R., Barisoni, L., et al. (2026) · eBioMedicine

Renal Diseases and GlomerulopathiesChronic Kidney Disease and Diabetes

Cited by 2