Mesenchymal stem cells in fibrotic disease

El Agha, Elie; Kramann, Rafael; Schneider, Rebekka K.; Li, Xiaokun; Seeger, Werner; Humphreys, Benjamin D.; Bellusci, Saverio

doi:10.1016/j.stem.2017.07.011

Cited by 430Mesenchymal stem cell researchTGF-β signaling in diseasesSystemic Sclerosis and Related Diseases

Mesenchymal stem cells in fibrotic disease

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El Agha, Elie, Kramann, Rafael, Schneider, Rebekka K., Li, Xiaokun, Seeger, Werner, Humphreys, Benjamin D., Bellusci, Saverio·2017·Cell stem cell

DOI 10.1016/j.stem.2017.07.011

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Abstract

Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in various diseases is thus a promising strategy for developing targeted anti-fibrotic treatments. Recent studies using genetic lineage tracing technology have implicated diverse organ-resident perivascular mesenchymal stem cell (MSC)-like cells and bone marrow-MSCs in myofibroblast generation during fibrosis development. In this Review, we give an overview of the emerging role of MSCs and MSC-like cells in myofibroblast-mediated fibrotic disease in the kidney, lung, heart, liver, skin, and bone marrow.

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BM mesenchymal stromal cells (BM-MSCs) are a rare population of cells in proximity to arterioles and sinusoid vessels (perivascular niche) or in proximity to the bone (endosteal niche).
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From Inflammatory bone marrow microenvironment (2019) · cites this paper as [6]

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Adult lung side population cells have mesenchymal stem cell potential
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Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification
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The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy
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ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling
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Cardiac mesenchymal stem cells contribute to scar formation after myocardial infarction
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Hepatic Stellate Cells Support Hematopoiesis and are Liver-Resident Mesenchymal Stem Cells
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Fibrocytes Are Not an Essential Source of Type I Collagen during Lung Fibrosis
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Telomere stability and telomerase in mesenchymal stem cells
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Global transcriptome analysis of human bone marrow stromal cells (BMSC) reveals proliferative, mobile and interactive cells that produce abundant extracellular matrix proteins, some of which may affect BMSC potency
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Hedgehog signaling pathway as key player in liver fibrosis: new insights and perspectives
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Abcg2 Expression Marks Tissue-Specific Stem Cells in Multiple Organs in a Mouse Progeny Tracking Model
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Telomere length analysis of human mesenchymal stem cells by quantitative PCR
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Mesenchymal stem cell-derived inflammatory fibroblasts mediate interstitial fibrosis in the aging heart
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Perivascular Cells in Diffuse Cutaneous Systemic Sclerosis Overexpress Activated ADAM12 and Are Involved in Myofibroblast Transdifferentiation and Development of Fibrosis
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Lysophosphatidic Acid Induces Migration of Human Lung-Resident Mesenchymal Stem Cells Through the β-Catenin Pathway
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Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis
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Bleomycin inhibits adipogenesis and accelerates fibrosis in the subcutaneous adipose layer through TGF ‐β1
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Mesenchymal stem cell-derived inflammatory fibroblasts promote monocyte transition into myeloid fibroblastsviaan IL-6-dependent mechanism in the aging mouse heart
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Fibrotic Skin Diseases
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Effect of nintedanib on cough and health related quality of life in patients with idiopathic pulmonary fibrosis
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Mesenchymal stem cell perspective: cell biology to clinical progress
Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., & Caplan, A. I. (2019) · npj Regenerative Medicine · doi:10.1038/s41536-019-0083-6 · Cited by 2,008 · see citing works
Coronavirus disease 2019 (COVID-19): current status and future perspectives
Li, H., Liu, S., Yu, X.-H., Tang, S., & Tang, C. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.105951 · Cited by 1,174 · see citing works
Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
Younesi, F. S., Miller, A. E., Barker, T. H., Rossi, F. M. V., & Hinz, B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00716-0 · Cited by 711 · see citing works
“However, multipotent perivascular ‘mural cells’ should be treated distinctly from adventitial fibroblasts as the latter lack progenitor potential, that is, the ability to differentiate into multiple different cell types 48–50 .”
Cancer-associated fibroblasts in gastrointestinal cancer
Kobayashi, H., Enomoto, A., Woods, S. L., Burt, A. D., Takahashi, M., & Worthley, D. L. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0115-0 · Cited by 596 · see citing works
Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies
Si, Z., Wang, X., Sun, C., Kang, Y., Xu, J., Wang, X., & Hui, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108765 · Cited by 425 · see citing works
CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement
Ulrich, H., & Pillat, M. M. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-09976-7 · Cited by 418 · see citing works
“This process is considered the first step in pathogenesis of pulmonary fibrosis [31].”
Background
The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication
Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396 · see citing works
The Role of MSC in Wound Healing, Scarring and Regeneration
Guillamat-Prats, R. (2021) · Cells · doi:10.3390/cells10071729 · Cited by 393 · see citing works
Resolution of organ fibrosis
Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 348 · see citing works
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis
Mizutani, Y., Kobayashi, H., Iida, T., Asai, N., Masamune, A., Hara, A., Esaki, N., Ushida, K., Mii, S., Shiraki, Y., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0454 · Cited by 339 · see citing works
The myofibroblast at a glance
Pakshir, P., Noskovicova, N., Lodyga, M., Son, D. O., Schuster, R., Goodwin, A., Karvonen, H., & Hinz, B. (2020) · Journal of Cell Science · doi:10.1242/jcs.227900 · Cited by 293 · see citing works
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
Kheirollahi, V., Wasnick, R. M., Biasin, V., Vazquez‐Armendariz, A. I., Chu, X., Moiseenko, A., Weiß, A., Wilhelm, J., Zhang, J., Kwapiszewska, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10839-0 · Cited by 292 · see citing works
Self-citation
Pathological mechanisms and therapeutic outlooks for arthrofibrosis
Usher, K. M., Zhu, S., Mavropalias, G., Carrino, J. A., Zhao, J., & Xu, J. (2019) · Bone Research · doi:10.1038/s41413-019-0047-x · Cited by 291 · see citing works
Identification, discrimination and heterogeneity of fibroblasts
Lendahl, U., Muhl, L., & Betsholtz, C. (2022) · Nature Communications · doi:10.1038/s41467-022-30633-9 · Cited by 242 · see citing works
Myofibroblast in Kidney Fibrosis: Origin, Activation, and Regulation
Yuan, Q., Tan, R. J., & Liu, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-8871-2_12 · Cited by 222 · see citing works
Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy
Malecová, B., Gatto, S., Etxaniz, U., Passafaro, M., Cortez, A., Nicoletti, C., Giordani, L., Torcinaro, A., Bardi, M. D., Bicciato, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06068-6 · Cited by 221 · see citing works
The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis
Kobayashi, H., Gieniec, K. A., Lannagan, T. R. M., Wang, T., Asai, N., Mizutani, Y., Iida, T., Ando, R., Thomas, E. M., Sakai, A., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.11.037 · Cited by 214 · see citing works
M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis
Hou, J., Shi, J., Chen, L., Lv, Z., Chen, X., Cao, H., Xiang, Z., & Han, X. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0300-8 · Cited by 199 · see citing works
Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer
Walraven, M., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.020 · Cited by 194 · see citing works
Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment
Kasembeli, M. M., Bharadwaj, U., Robinson, P., & Tweardy, D. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082299 · Cited by 199 · see citing works
“The persistent expansion and activation of tissue myofibroblasts is a salient feature of fibrosis and a major driver of disease progression [167].”
Background
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
Leimkühler, N. B., Gleitz, H. F. E., Li, R., Snoeren, I., Fuchs, S. N. R., Nagai, J. S., Banjanin, B., Lam, K. H., Vogl, T., Kuppe, C., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.11.004 · Cited by 178 · see citing works
Multipotent stromal cells: One name, multiple identities
Soliman, H., Theret, M., Scott, W., Hill, L., Underhill, T. M., Hinz, B., & Rossi, F. M. V. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.09.001 · Cited by 147 · see citing works
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure
Liang, H., Huang, K., Su, T., Li, Z., Hu, S., Dinh, P., Wrona, E. A., Shao, C., Qiao, L., Vandergriff, A. C., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00553 · Cited by 142 · see citing works
Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration
Sagaradze, G. D., Basalova, N. A., Efimenko, A. Y., & Va, T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.576176 · Cited by 140 · see citing works
Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging
Théret, M., Rossi, F. M. V., & Contreras, O. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.673404 · Cited by 144 · see citing works
Mesenchymal stem cells: From regeneration to cancer
Li, P., Gong, Z., Shultz, L. D., & Ren, G. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.005 · Cited by 134 · see citing works
Differential contribution of pancreatic fibroblast subsets to the pancreatic cancer stroma
Garcia, P. E., Adoumie, M., Kim, E. C., Zhang, Y., Scales, M. K., El-Tawil, Y. S., Shaikh, A. Z., Wen, H.-J., Bednar, F., Allen, B. L., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.05.004 · Cited by 110 · see citing works
Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment
Yang, X., Li, Q., Liu, W., Zong, C., Wei, L., Shi, Y., & Han, Z. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-00983-5 · Cited by 120 · see citing works
Mesenchymal stem cells and macrophages and their interactions in tendon-bone healing
Chen, Z., Jin, M., He, H., Dong, J., Li, J., Nie, J., Wang, Z., Xu, J., & Wu, F. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.12.005 · Cited by 116 · see citing works
“firstly isolated MSCs from colonies in vitro and described them as plastic-adherent fibroblast-like cells [60].”
Background
Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out
Zent, J. M., & Guo, L. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493217 · Cited by 115 · see citing works
circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA
Zhang, J., Lu, J. L., Xie, H., Wang, D.-P., Ni, H., Zhu, Y., Ren, L., Meng, X., & Wang, R. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1430-7 · Cited by 114 · see citing works
Systematic comparison of hUC-MSCs at various passages reveals the variations of signatures and therapeutic effect on acute graft-versus-host disease
Zhao, Q., Zhang, L., Wei, Y., Yu, H., Zou, L., Huo, J., Yang, H., Song, B., Wei, T., Wu, D., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1478-4 · Cited by 114 · see citing works
Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp
Cheng, H., Onder, L., Novković, M., Soneson, C., Lütge, M., Pikor, N. B., Scandella, E., Robinson, M. D., Miyazaki, J., Tersteegen, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09728-3 · Cited by 111 · see citing works
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin
Qin, L., Liu, N., Bao, C.-L.-M., Yang, D.-Z., Ma, G.-X., Yi, W.-H., Xiao, G.-Z., & Cao, H.-L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00952-0 · Cited by 114 · see citing works
“Internal MSCs as one major source of myofibroblasts Unlike the micro-environment of many other diseases, such as degenerative diseases and inflammations, one of the characterizations of fibrotic diseases is aberrant myofibroblast accumulation [189, 190].”
BackgroundInfluential
Mesenchymal stem cell-associated lncRNA in osteogenic differentiation
Ju, C., Liu, R., Zhang, Y., Zhang, Y., Zhou, R., Sun, J., Lv, X.-B., & Zhang, Z. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108912 · Cited by 110 · see citing works
Exosomes derived from hucMSC attenuate renal fibrosis through CK1δ/β-TRCP-mediated YAP degradation
Ji, C., Zhang, J., Zhu, Y. X., Shi, H., Yin, S., Sun, F., Wang, Q., Zhang, L., Yan, Y., Zhang, X., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2510-4 · Cited by 102 · see citing works
microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney
Srivastava, S. P., Hedayat, A. F., Kanasaki, K., & Goodwin, J. E. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00904 · Cited by 98 · see citing works
Effect of 2D and 3D Culture Microenvironments on Mesenchymal Stem Cell-Derived Extracellular Vesicles Potencies
Kusuma, G. D., Li, A., Zhu, D., McDonald, H., Inocencio, I. M., Chambers, D. C., Sinclair, K. A., Fang, H., Greening, D. W., Frith, J. E., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.819726 · Cited by 98 · see citing works
Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis
Kramann, R., Machado, F. G., Wu, H., Kusaba, T., Hoeft, K., Schneider, R. K., & Humphreys, B. D. (2018) · JCI Insight · doi:10.1172/jci.insight.99561 · Cited by 94 · see citing works
Human menstrual blood-derived stem cells mitigate bleomycin-induced pulmonary fibrosis through anti-apoptosis and anti-inflammatory effects
Chen, X., Wu, Y., Wang, Y., Chen, L., Zheng, W., Zhou, S., Xu, H., Li, Y., Yuan, L., & Xiang, C. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01926-x · Cited by 91 · see citing works
Advances and clinical challenges of mesenchymal stem cell therapy
Mei, R., Wan, Z., Yang, C., Shen, X., Wang, R., Zhang, H., Yang, R., Li, J., Song, Y., & Su, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1421854 · Cited by 90 · see citing works
Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells
Han, X., Na, T., Wu, T., & Yuan, B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227174 · Cited by 89 · see citing works
m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation
Zhang, J., Huang, P.-J., Wang, D.-P., Yang, W.-Y., Lu, J. L., Zhu, Y., Meng, X., Wu, X., Lin, Q., Lv, H., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.06.008 · Cited by 87 · see citing works
Inflammatory bone marrow microenvironment
Leimkühler, N. B., & Schneider, R. K. (2019) · Hematology · doi:10.1182/hematology.2019000045 · Cited by 82 · see citing works
“Studies focusing on different myeloid diseases and also different niche cells were able to mechanistically elucidate how malignant, mutated hematopoietic cells and also proinflammatory cytokines activate distinct subsets of stromal cells in the BM, increase their secretory activity, and influence their reduced hematop…”
BackgroundSelf-citation
Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice
Han, M.-M., He, X.-Y., Tang, L., Qi, L., Yang, M.-Y., Wang, Y., Xing, L., Jeong, J.-H., & Jiang, H.-L. (2023) · Science Advances · doi:10.1126/sciadv.adg5358 · Cited by 86 · see citing works
Extracellular matrix stiffness—The central cue for skin fibrosis
Wang, K., Wen, D., Xu, X., Zhao, R., Jiang, F., Yuan, S., Zhang, Y., Gao, Y., & Li, Q. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1132353 · Cited by 84 · see citing works
Decorin-Modified Umbilical Cord Mesenchymal Stem Cells (MSCs) Attenuate Radiation-Induced Lung Injuries via Regulating Inflammation, Fibrotic Factors, and Immune Responses
Liu, D., Kong, F., Yuan, Y., Seth, P. K., Xu, W., Wang, H., FengJun, X. I. A. O., Ls, W., Ql, Z., Wang, H., et al. (2018) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2018.04.007 · Cited by 83 · see citing works
Monocyte-derived multipotent cell delivered programmed therapeutics to reverse idiopathic pulmonary fibrosis
Chang, X., Xing, L., Wang, Y., Yang, C.-X., He, Y., Zhou, T., Gao, X., Li, L., Hao, H., & Jiang, H. (2020) · Science Advances · doi:10.1126/sciadv.aba3167 · Cited by 83 · see citing works
Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment
Li, M., Huang, H., Wei, X., Li, H., Li, J., Xie, B., Yang, Y., Fang, X., Wang, L., Zhang, X., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02262-3 · Cited by 83 · see citing works
Prophylactic treatment with MSC-derived exosomes attenuates traumatic acute lung injury in rats
Li, Q., Liang, Y., & Su, Z. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00391.2018 · Cited by 79 · see citing works
Retracted
The Role of Nrf2 in Pulmonary Fibrosis: Molecular Mechanisms and Treatment Approaches
Wang, Y., Wei, J., Deng, H., Zheng, L., Yang, H. Y., & Lv, X. (2022) · Antioxidants · doi:10.3390/antiox11091685 · Cited by 80 · see citing works
Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies
Di, X., Li, Y., Wei, J., Li, T., & Liao, B. (2024) · Advanced Science · doi:10.1002/advs.202410416 · Cited by 83 · see citing works
The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet
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Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice
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Authors: El Agha, E., Kramann, R., Schneider, R. K., Li, X., Seeger, W., Humphreys, B. D., & Bellusci, S.
Affiliations: RWTH Aachen University (DE)
Erasmus MC Cancer Institute (NL)
Wenzhou University (CN)
Justus-Liebig-Universität Gießen (DE)
Washington University in St. Louis (US)
ORCID: Kramann, Rafael
Schneider, Rebekka K.
Li, Xiaokun
Seeger, Werner
Humphreys, Benjamin D.
Venue: Cell stem cell
Publisher: Elsevier BV
Published: 2017-08
Volume: 21
Issue: 2
Pages: 166-177
ISSN: 1875-9777 (ISSN-L)
1934-5909
DOI: 10.1016/j.stem.2017.07.011
OpenAlex: W2743476964
Cited by: 430
References: 99
Citations by year: 2026: 15 · 2025: 32 · 2024: 54 · 2023: 44 · 2022: 78 · 2021: 66 · 2020: 70 · 2019: 42 · 2018: 26 · 2017: 1 · 2014: 1 · 2012: 1
FWCI: 5.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell stem cell (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Excellence Cluster Cardio-Pulmonary System (ECCPS)
Universitätsklinikum Gießen und Marburg (UKGM)
German Center for Lung Research (DZL)
German Research Foundation
DFG (BE4443/4-1, BE4443/6-1, KFO 309, CRC1213, SCHN 1188/5-1, KR-4073/3-1, SFBTRR57)
Landes-Offensive zur Entwicklung Wissenschaftlich-ökonomischer Exzellenz (LOEWE)
UKGM
Universities of Giessen and Marburg Lung Center (UGMLC)
DZL
COST (BM1201)
NIH/NHLBI (1R01HL086322-01A2, HL107307)
Interdisciplinary Center for Clinical Research (IZKF) RWTH Aachen (O1-5)
European Hematology Association (EHA)
European Research Council (ERC-StG 677448)
RWTH Aachen University (101/15)
Return to NRW)
NIH/NIDDK (DK088923, DK103740, DK103050)
American Heart Association (EIA14650059)
Topics: Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
Keywords: mesenchymal stem cells, fibrosis, myofibroblast accumulation, perivascular stem cells, bone marrow-derived mesenchymal stem cells, lineage tracing, renal fibrosis, pulmonary fibrosis, myocardial fibrosis, liver fibrosis, skin fibrosis, bone marrow fibrosis, antifibrotic therapy
MeSH terms: Animals, Fibrosis, Humans, Organ Specificity, Mesenchymal Stem Cells

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Mesenchymal stem cells in fibrotic disease

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