Verstegen, Monique M. A.

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Huch, M., Gehart, H., van Boxtel, R., Hamer, K., Blokzijl, F., Verstegen, M. M. A., Ellis, E., van Wenum, M., Fuchs, S. A., de Ligt, J., et al. (2015) · Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

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Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Broutier, L., Mastrogiovanni, G., Verstegen, M. M., Francies, H. E., Gavarró, L. M., Bradshaw, C. R., Allen, G. E., Arnes-Benito, R., Sidorova, O., Gaspersz, M. P., et al. (2017) · Nature Medicine

Cancer Cells and MetastasisHepatocellular Carcinoma Treatment and Prognosis

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Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., et al. (2016) · Nature

Cancer Genomics and DiagnosticsGenetic factors in colorectal cancer

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Large‐Scale Production of LGR5‐Positive Bipotential Human Liver Stem Cells

Schneeberger, K., Sánchez‐Romero, N., Ye, S., van Steenbeek, F. G., Oosterhoff, L. A., Pla Palacin, I., Chen, C., van Wolferen, M. E., van Tienderen, G., Lieshout, R., et al. (2020) · Hepatology

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

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Hydrogels derived from decellularized liver tissue support the growth and differentiation of cholangiocyte organoids

Willemse, J., van Tienderen, G., van Hengel, E., Schurink, I., van der Ven, D., Kan, Y., de Ruiter, P., Rosmark, O., Westergren-Thorsson G, G., Schneeberger, K., et al. (2022) · Biomaterials

Tissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

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Fast, robust and effective decellularization of whole human livers using mild detergents and pressure controlled perfusion

Willemse, J., Verstegen, M. M. A., Vermeulen, A., Schurink, I. J., Roest, H. P., van der Laan, L. J. W., & de Jonge, J. (2020) · Materials Science and Engineering: C

Tissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

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Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

Verstegen, M. M. A., Roos, F. J. M., Burka, K., Gehart, H., Jager, M., de Wolf, M., Bijvelds, M. J. C., de Jonge, H. R., Ardisasmita, A. I., van Huizen, N. A., et al. (2020) · Scientific Reports

Pediatric Hepatobiliary Diseases and TreatmentsLiver physiology and pathology

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Extracellular matrix drives tumor organoids toward desmoplastic matrix deposition and mesenchymal transition

van Tienderen, G. S., Rosmark, O., Lieshout, R., Willemse, J., de Weijer, F., Elowsson Rendin, L., Westergren-Thorsson, G., Doukas, M., Groot Koerkamp, B., van Royen, M. E., et al. (2023) · Acta Biomaterialia

Cholangiocarcinoma and Gallbladder Cancer StudiesTissue Engineering and Regenerative Medicine

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Cholangiocyte organoids from human bile retain a local phenotype and can repopulate bile ducts in vitro

Roos, F. J. M., Wu, H., Willemse, J., Lieshout, R., Albarinos, L. A. M., Kan, Y., Poley, J., Bruno, M. J., de Jonge, J., Bártfai, R., et al. (2021) · Clinical and Translational Medicine

Liver physiology and pathologyPediatric Hepatobiliary Diseases and Treatments

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Scaffolds obtained from decellularized human extrahepatic bile ducts support organoids to establish functional biliary tissue in a dish

Willemse, J., Roos, F. J. M., Voogt, I. J., Schurink, I. J., Bijvelds, M., de Jonge, H. R., van der Laan, L. J. W., de Jonge, J., & Verstegen, M. M. A. (2021) · Biotechnology and Bioengineering

Tissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

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Scalable Production of Size-Controlled Cholangiocyte and Cholangiocarcinoma Organoids within Liver Extracellular Matrix-Containing Microcapsules

van Tienderen, G. S., Willemse, J., van Loo, B., van Hengel, E. V. A., de Jonge, J., van der Laan, L. J. W., Leijten, J., & Verstegen, M. M. A. (2022) · Cells

3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques Innovation

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Cholangiocyte organoids to study drug-induced injury

Wang, Z., Xing, C., van der Laan, L. J. W., Verstegen, M. M. A., Spee, B., & Masereeuw, R. (2024) · Stem Cell Research & Therapy

Drug-Induced Hepatotoxicity and ProtectionDrug Transport and Resistance Mechanisms

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