Shimano, Hitoshi

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology

Shimano, H., & Sato, R. (2017) · Nature Reviews Endocrinology

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 1,174

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression

Sekiya, M., Yahagi, N., Matsuzaka, T., Najima, Y., Nakakuki, M., Nagai, R., Ishibashi, S., Osuga, J.-I., Yamada, N., & Shimano, H. (2003) · Hepatology

Liver Disease Diagnosis and TreatmentFatty Acid Research and Health

Cited by 415

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

Oishi, Y., Spann, N. J., Link, V. M., Muse, E. D., Strid, T., Edillor, C., Kolar, M. J., Matsuzaka, T., Hayakawa, S., Tao, J., et al. (2017) · Cell Metabolism

Fatty Acid Research and HealthImmune Response and Inflammation

Cited by 342

HbA1c 5·7–6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study

Heianza, Y., Hara, S., Arase, Y., Saito, K., Fujiwara, K., Tsuji, H., Kodama, S., Hsieh, S. D., Mori, Y., Shimano, H., et al. (2011) · The Lancet

Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

Cited by 260

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice

Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Sowa, N., Yahagi, N., et al. (2013) · Nature Communications

MicroRNA in disease regulationCholesterol and Lipid Metabolism

Cited by 230

Association Between Physical Activity and Risk of All-Cause Mortality and Cardiovascular Disease in Patients With Diabetes

Kodama, S., Tanaka, S., Heianza, Y., Fujihara, K., Horikawa, C., Shimano, H., Saito, K., Yamada, N., Ohashi, Y., & Sone, H. (2013) · Diabetes Care

Physical Activity and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 212

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages

Karasawa, T., Kawashima, A., Usui-Kawanishi, F., Watanabe, S., Kimura, H., Kamata, R., Shirasuna, K., Koyama, Y., Sato-Tomita, A., Matsuzaka, T., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 162

Influence of fat and carbohydrate proportions on the metabolic profile in patients with type 2 diabetes: a meta-analysis

Kodama, S., Saito, K., Tanaka, S., Maki, M., Yachi, Y., Sato, M., Sugawara, A., Totsuka, K., Shimano, H., Ohashi, Y., et al. (2009) · Diabetes Care

Diet and metabolism studiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 160

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential: A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation

Fruchart, J.-C., Santos, R. D., Aguilar-Salinas, C., Aikawa, M., Al Rasadi, K., Amarenco, P., Barter, P. J., Ceska, R., Corsini, A., Després, J.-P., et al. (2019) · Cardiovascular Diabetology

Peroxisome Proliferator-Activated ReceptorsLipoproteins and Cardiovascular Health

Cited by 140

SCAP is required for timely and proper myelin membrane synthesis

Verheijen, M. H. G., Camargo, N., Verdier, V., Nadra, K., de Preux Charles, A.-S., Médard, J.-J., Luoma, A., Crowther, M., Inouye, H., Shimano, H., et al. (2009) · Proceedings of the National Academy of Sciences

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 119

MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

Hamada, M., Nakamura, M., Tran, M. T. N., Moriguchi, T., Hong, C., Ohsumi, T., Dinh, T. T. H., Kusakabe, M., Hattori, M., Katsumata, T., et al. (2014) · Nature Communications

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 111

Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet

Wada, T., Miyashita, Y., Sasaki, M., Aruga, Y., Nakamura, Y., Ishii, Y., Sasahara, M., Kanasaki, K., Kitada, M., Koya, D., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 79

Diabetes Mellitus and Risk of New-Onset and Recurrent Heart Failure: A Systematic Review and Meta-Analysis

Kodama*, S., Fujihara, K., Horikawa, C., Sato, T., Iwanaga, M., Yamada, T., Kato, K., Watanabe, K., Shimano, H., Izumi, T., et al. (2020) · ESC Heart Failure

Heart Failure Treatment and ManagementCardiovascular Function and Risk Factors

Cited by 63

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

Kato, T., Shimano, H., Yamamoto, T., Yokoo, T., Endo, Y., Ishikawa, M., Matsuzaka, T., Nakagawa, Y., Kumadaki, S., Yahagi, N., et al. (2006) · Cell Metabolism

Pancreatic function and diabetesEndoplasmic Reticulum Stress and Disease

Cited by 62

Longitudinal Trajectories of HbA1c and Fasting Plasma Glucose Levels During the Development of Type 2 Diabetes

Heianza, Y., Arase, Y., Fujihara, K., Hsieh, S. D., Saito, K., Tsuji, H., Kodama, S., Yahagi, N., Shimano, H., Yamada, N., et al. (2012) · Diabetes Care

Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

Cited by 56

MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo

Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Nakazeki, F., Ide, Y., et al. (2014) · Scientific Reports

Cholesterol and Lipid MetabolismMicroRNA in disease regulation

Cited by 49

Role of alcohol drinking pattern in type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 11 (TOPICS 11)

Heianza, Y., Arase, Y., Saito, K., Tsuji, H., Fujihara, K., Hsieh, S. D., Kodama, S., Shimano, H., Yamada, N., Hara, S., et al. (2013) · The American Journal of Clinical Nutrition

Alcohol Consumption and Health EffectsDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 46

Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice

Takei, K., Nakagawa, Y., Wang, Y., Han, S.-I., Satoh, A., Sekiya, M., Matsuzaka, T., & Shimano, H. (2017) · Journal of Pharmacological Sciences

Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

Cited by 43

Network meta‐analysis of the relative efficacy of bariatric surgeries for diabetes remission

Kodama, S., Fujihara, K., Horikawa, C., Harada, M., Ishiguro, H., Kaneko, M., Furukawa, K., Matsubayashi, Y., Matsunaga, S., Shimano, H., et al. (2018) · Obesity Reviews

Bariatric Surgery and OutcomesMinimally Invasive Surgical Techniques

Cited by 42

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry

Sawada, Y., Izumida, Y., Takeuchi, Y., Aita, Y., Wada, N., Li, E., Murayama, Y., Piao, X., Shikama, A., Masuda, Y., et al. (2017) · Biochemical and Biophysical Research Communications

Pharmacology and Obesity TreatmentRegulation of Appetite and Obesity

Cited by 31

Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis

Kodama, S., Horikawa, C., Fujihara, K., Ishii, D., Hatta, M., Takeda, Y., Kitazawa, M., Matsubayashi, Y., Shimano, H., Kato, K., et al. (2018) · Clinical Nutrition ESPEN

Nutritional Studies and DietDiet, Metabolism, and Disease

Cited by 19

Quantitative Relationship Between Cumulative Risk Alleles Based on Genome-Wide Association Studies and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis

Kodama, S., Fujihara, K., Ishiguro, H., Horikawa, C., Ohara, N., Yachi, Y., Tanaka, S., Shimano, H., Kato, K., Hanyu, O., et al. (2018) · Journal of Epidemiology

Genetic Associations and EpidemiologyNutrition, Genetics, and Disease

Cited by 18

Dose-dependent effect of niceritrol on plasma lipoprotein-a

Teramoto, T., Yamada, N., Shimano, H., Oka, Y., Itakura, H., Saito, Y., Morisaki, N., Shirai, K., Ishikawa, T., Tada, N., et al. (1996) · Scandinavian Journal of Clinical and Laboratory Investigation

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 13

Label-free imaging of intracellular structures in living mammalian cells via external apodization phase-contrast microscopy

Ohno, H., Nishimura, T., Kainoh, K., Ohashi, Y., Onodera, N., Kano, M., Sari, L. N., Masuda, M., Tamura, Y., Hayashi, Y., et al. (2024) · FEBS Journal

Digital Holography and MicroscopyAdvanced Fluorescence Microscopy Techniques

Cited by 2