Dose-dependent effect of niceritrol on plasma lipoprotein-a
Open accessAbstract
Lipoprotein-a, Lp(a), is a variant form of low density lipoprotein (LDL) that contains apolipoprotein-a, whose structure has 75-85% homology with plasminogen. Elevated plasma levels of Lp(a) are considered to be one of the independent risk factors for cardiovascular disease. We studied the effects of niceritrol, a nicotinic acid derivative, on plasma Lp(a) levels in 72 patients with hypercholesterolaemia. The dose of niceritrol was increased every 4 weeks, from 750 to 1500 and then to 2250 mg day-1. The final dose was adjusted to obtain a plasma cholesterol level less than 5.69 mmol l-1. Niceritrol led to significant decreases in plasma levels of median Lp(a), from 16.1 mg dl-1 (interquartile intervals, 8.7 to 32.8) to 11.1 mg dl-1 (interquartile intervals, 6.6 to 21), the mean reduction rate being 17.6%. In the group with pretreatment Lp(a) levels of over 20 mg dl-1, Lp(a) decreased by 10.0, 22.0 and 31.8% at the doses of 750, 1500, and 2250 mg day-1, respectively. In the group with levels less than 20 mg dl-1, only the dose of 2250 mg day-1 was effective in the reduction of Lp(a). The results suggest that the reduction of Lp(a) was dependent on the dose of niceritrol and on the pretreatment level of Lp(a). In conclusion, niceritrol is effective, in a dose-dependent manner, for reducing Lp(a) levels.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fibrates activate PPARα, a nuclear receptor, by binding as ligands.
“Their primary mechanism of action is the activation of PPARα, a nuclear receptor, through binding of fibrates as ligands686, 687).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [687]
Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
Canner, P. L., Berge, K. G., Wenger, N. K., Stamler, J., Friedman, L., Prineas, R. J., & Friedewald, W. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80293-5 · Cited by 1,824 · see citing works
A NEW SERUM TYPE SYSTEM IN MAN—THE Lp SYSTEM
Berg, K. (1963) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/j.1699-0463.1963.tb01808.x · Cited by 1,377 · see citing works
Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year follow-up
Cashin-Hemphill, L. (1990) · JAMA · doi:10.1001/jama.264.23.3013 · Cited by 493 · see citing works
Schaefer, E. J. (1994) · JAMA · doi:10.1001/jama.1994.03510370051031 · Cited by 487 · see citing works
CARLSON, L. A., HAMSTEN, A., & ASPLUND, A. (1989) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1989.tb01393.x · Cited by 443 · see citing works
HMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels.
Kostner, G. M., Gavish, D., Leopold, B., Bolzano, K., Weintraub, M. S., & Breslow, J. L. (1989) · Circulation · doi:10.1161/01.cir.80.5.1313 · Cited by 339 · see citing works
Cremer, P., Nagel, D., Labrot, B., Mann, H., Muche, R., Elster, H., & Seidel, D. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb02373.x · Cited by 298 · see citing works
Warnick, G. R., & Albers, J. J. (1978) · Clinical Chemistry · doi:10.1093/clinchem/24.6.900 · Cited by 179 · see citing works
Diverging effects of cholestyramine on apolipoprotein B and lipoprotein Lp(a)
Vessby, B., Kostner, G. M., Lithell, H., & Thomis, J. A. (1982) · Atherosclerosis · doi:10.1016/0021-9150(82)90053-3 · Cited by 145 · see citing works
Rapid Angiographic Progression of Coronary Artery Disease in Patients With Elevated Lipoprotein(a)
Terres, W., Tatsis, E., Pfalzer, B., Beil, F. U., Beisiegel†, U., & Hamm, C. W. (1995) · Circulation · doi:10.1161/01.cir.91.4.948 · Cited by 142 · see citing works
Desmarais, R. L., Sarembock, I. J., Ayers, C. R., Vernon, S. M., Powers, E. R., & Gimple, L. W. (1995) · Circulation · doi:10.1161/01.cir.91.5.1403 · Cited by 131 · see citing works
Hiraga, T., Kobayashi, T., Okubo, M., Nakanishi, K., Sugimoto, T., Ohashi, Y., & Murase, T. (1995) · Diabetes Care · doi:10.2337/diacare.18.2.241 · Cited by 69 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 317 · see citing works
Takeshita, M., Katsuragi, Y., Kusuhara, M., Higashi, K., Miyajima, E., Mizuno, K., Mori, K., Obata, T., Ohmori, R., Ohsuzu, F., et al. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.05.009 · Cited by 24 · see citing works
Effects of niceritrol on faecal and urinary phosphate excretion in normal rats
Kuboyama, N., Watanabe, Y., Yamaguchi, M., Sato, K., Suzuki, T., & Akiba, T. (1999) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/14.3.610 · Cited by 23 · see citing works
Tsuchida, K., Hori, T., Tanabe, N., Makiyama, Y., Ozawa, T., Saigawa, T., Watanabe, R., Tanaka, T., Nasuno, A., Fukunaga, H., et al. (2005) · Circulation Journal · doi:10.1253/circj.69.521 · Cited by 16 · see citing works
Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S., Egusa, G., Hiro, T., Hirobe, K., Iida, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.19166 · Cited by 13 · see citing works
Self-citationEffects of phytosterols in diacylglycerol as part of diet therapy on hyperlipidemia in children.
Matsuyama, T., Shoji, K., Takase, H., Kamimaki, I., Tanaka, Y., Otsuka, A., Watanabe, H., Hase, T., & Tokimitsu, I. (2007) · PubMed · Cited by 13 · see citing works
Takeshita, M., Saito, S., Katsuragi, Y., Yasunaga, K., Matsuo, N., Tokimitsu, I., Yasukawa, T., & Nakamura, H. (2007) · e-SPEN the European e-Journal of Clinical Nutrition and Metabolism · doi:10.1016/j.eclnm.2006.11.001 · Cited by 10 · see citing works
Fujii, E., Ako, J., Takahashi, Y., Toda, M., Iekushi, K., & Yamashita, S. (2024) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.64953 · Cited by 5 · see citing works
Teramoto, T., Sasaki, J., Ueshima, H., Egusa, G., Kinoshita, M., Shimamoto, K., Daida, H., Biro, S., Hirobe, K., Funahashi, T., et al. (2008) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.e619 · Cited by 4 · see citing works
Self-citationThe Effects of Combination Therapy with Niceritrol and Pravastatin on Hyperlipidaemia
Kinoshita, M., Mikuni, Y., Kudo, M., Mori, M., Horie, E., Teramoto, T., & Matsushima, T. (2002) · Journal of International Medical Research · doi:10.1177/147323000203000308 · Cited by 3 · see citing works
Self-citationNasiff-Hadad, A., Ramos-Marín, P., Simón-Carballo, R., Cordero-Rojas, N., Soto, J., & Meriño-Ibarra, E. (2003) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(03)78890-1
Rajbhandari, R., Raut, R., Rajbhandari, S., Malla, R., Maskey, A., Man Bahadur, K. C., Limbu, Y., Bhatta, Y., Sharma, D., Sharma, R., et al. (2013) · Journal of Advances in Internal Medicine · doi:10.3126/jaim.v2i2.8778
- Authors
- Teramoto, T., Yamada, N., Shimano, H., Oka, Y., Itakura, H., Saito, Y., Morisaki, N., Shirai, K., Ishikawa, T., Tada, N., Ito, H., Yamanouchi, T., Matsushima, T., Kawakami, M., Murase, T., Okubo, M., Totsuka, Y., & Kikuchi, M.
- Affiliations
- Teikyo University (JP)
- The University of Tokyo (JP)
- Yamaguchi University (JP)
- Chiba University (JP)
- Toho University (JP)
- National Defense Medical College Hospital (JP)
- Jikei University School of Medicine (JP)
- The Institute of Medical Science, Asahi Life Foundation (JP)
- University of Tsukuba (JP)
- Jichi Medical University (JP)
- Toranomon Hospital (JP)
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 56
- Issue
- 4
- Pages
- 359-365
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2164484250
- Cited by
- 13
- References
- 14
- Citations by year
- 2024: 1 · 2023: 1 · 2018: 1 · 2013: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- Locations
- Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- nicotinic acid derivatives, lipoprotein(a), dose-dependent effects, hypercholesterolemia, apolipoprotein(a), cardiovascular risk factors, plasma cholesterol lowering
- MeSH terms
- Aged, Hypolipidemic Agents, Dose-Response Relationship, Drug, Female, Humans, Hyperlipidemias, Male, Middle Aged, Niceritrol, Lipoprotein(a)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
