Eggen, Bart J.L.

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

Galatro, T. F., Holtman, I. R., Lerario, A. M., Vainchtein, I. D., Brouwer, N., Sola, P. R., Veras, M. M., Pereira, T. F., Leite, R. E. P., Möller, T., et al. (2017) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 741

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

Holtman, I. R., Raj, D. D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., et al. (2015) · Acta Neuropathologica Communications

Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Cited by 619

A novel microglial subset plays a key role in myelinogenesis in developing brain

Wlodarczyk, A., Holtman, I. R., Krueger, M., Yogev, N., Bruttger, J., Khorooshi, R., Benmamar‐Badel, A., de Boer‐Bergsma, J. J., Martin, N. A., Karram, K., et al. (2017) · The EMBO Journal

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 535

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease

Gerrits, E., Brouwer, N., Kooistra, S. M., Woodbury, M. E., Vermeiren, Y., Lambourne, M., Mulder, J., Kummer, M., Möller, T., Biber, K., et al. (2021) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 441

Identification of a microglia phenotype supportive of remyelination

Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K., & Boddeke, H. W. G. M. (2012) · Glia

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 358

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., et al. (2017) · Neurobiology of Aging

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 238

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

Mattei, D., Ivanov, A., Ferrai, C., Jordan, P., Guneykaya, D., Buonfiglioli, A., Schaafsma, W., Przanowski, P., Deuther-Conrad, W., Brust, P., et al. (2017) · Translational Psychiatry

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 222

Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis

Van der Borght, K., Kóbor‐Nyakas, D. É., Klauke, K., Eggen, B. J. L., Nyakas, C., Van der Zee, E. A., & Meerlo, P. (2009) · Hippocampus

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 210

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Yin, Z., Rosenzweig, N., Kleemann, K. L., Zhang, X., Brandão, W., Margeta, M. A., Schroeder, C., Sivanathan, K. N., Silveira, S., Gauthier, C., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 202

Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain

Raj, D., Yin, Z., Breur, M., Doorduin, J., Holtman, I. R., Olah, M., Mantingh-Otter, I. J., Van Dam, D., De Deyn, P. P., den Dunnen, W., et al. (2017) · Frontiers in Molecular Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 180

Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease

Wes, P. D., Holtman, I. R., Boddeke, E. W. G. M., Möller, T., & Eggen, B. J. L. (2016) · Glia

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 167

Transcriptional profiling of microglia; current state of the art and future perspectives

Gerrits, E., Heng, Y., Boddeke, E. W. G. M., & Eggen, B. J. L. (2020) · Glia

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 140

CD 14 is a key organizer of microglial responses to CNS infection and injury

Janova, H., Böttcher, C., Holtman, I. R., Regen, T., van Rossum, D., Götz, A., Ernst, A., Fritsche, C., Gertig, U., Saiepour, N., et al. (2016) · Glia

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 105

In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

Vainchtein, I. D., Vinet, J., Brouwer, N., Brendecke, S., Biagini, G., Biber, K., Boddeke, H. W. G. M., & Eggen, B. J. L. (2014) · Glia

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 92

VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases

Borggrewe, M., Grit, C., Den Dunnen, W. F. A., Burm, S. M., Bajramovic, J. J., Noelle, R. J., Eggen, B. J. L., & Laman, J. D. (2018) · Glia

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 91

Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Miedema, A., Gerrits, E., Brouwer, N., Jiang, Q., Kracht, L., Meijer, M., Nutma, E., Peferoen-Baert, R., Pijnacker, A. T. E., Wesseling, E. M., et al. (2022) · Acta Neuropathologica Communications

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 65

Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model

Scheffold, A., Holtman, I. R., Dieni, S., Brouwer, N., Katz, S.-F., Jebaraj, B. M. C., Kahle, P. J., Hengerer, B., Lechel, A., Stilgenbauer, S., et al. (2016) · Acta Neuropathologica Communications

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 53

Identification of distinct and age‐dependent p16High microglia subtypes

Talma, N., Gerrits, E., Wang, B., Eggen, B. J. L., & Demaria, M. (2021) · Aging Cell

Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 46

Spatially resolved gene signatures of white matter lesion progression in multiple sclerosis

Alsema, A. M., Wijering, M. H. C., Miedema, A., Kotah, J. M., Koster, M., Rijnsburger, M., van Weering, H. R. J., de Vries, H. E., Baron, W., Kooistra, S. M., et al. (2024) · Nature Neuroscience

Multiple Sclerosis Research StudiesSingle-cell and spatial transcriptomics

Cited by 38

Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus

Matera, A., Compagnion, A.-C., Pedicone, C., Kotah, J. M., Ivanov, A., Monsorno, K., Labouèbe, G., Leggio, L., Pereira-Iglesias, M., Beule, D., et al. (2025) · Immunity

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 34

Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View

Eggen, B. J. L., Boddeke, E. W. G. M., & Kooistra, S. M. (2019) · Neuroscience

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 34

Glioblastoma and its treatment are associated with extensive accelerated brain aging

Ainslie, A. P., Klaver, M., Voshart, D. C., Gerrits, E., den Dunnen, W. F. A., Eggen, B. J. L., Bergink, S., & Barazzuol, L. (2024) · Aging Cell

Glioma Diagnosis and TreatmentCancer-related cognitive impairment studies

Cited by 17

Glioblastoma is associated with extensive accelerated brain ageing

Ainslie, A. P., Klaver, M., Voshart, D. C., Gerrits, E., Eggen, B. J. L., Bergink, S., & Barazzuol, L. (2022) · Aging Cell

Glioma Diagnosis and TreatmentCancer-related cognitive impairment studies

Cited by 16