Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View
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Different methods of isolation (e.g., immunopanning, FACS, magnetic bead sorting) can differentially alter the activation status of microglia and hence gene expression, potentially contributing to differing reports of baseline sexual dimorphism in studies of microglia.
“While an unavoidable caveat, it has been shown that different methods of isolation (ie. immunopanning, FACS, magnetic bead sorting) can differentially alter the activation status of microglia and hence gene expression, potentially contributing to differing reports of baseline sexual dimorphism in studies of microglia40.”
From Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system (2023) · cites this paper as [40]
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Uncovering sex differences of rodent microglia
Han, J., Fan, Y., Zhou, K., Blomgren, K., & Harris, R. A. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02124-z · Cited by 224 · see citing works
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- Authors
- Eggen, B. J. L., Boddeke, E. W. G. M., & Kooistra, S. M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 405
- Pages
- 3-13
- ISSN
- 0306-4522
- Cited by
- 25
- References
- 22
- Language
- en
- Funders
- Netherlands Organisation for Scientific Research
- Stichting MS research
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