Knudsen, Erik S.

The history and future of targeting cyclin-dependent kinases in cancer therapy

Asghar, U., Witkiewicz, A. K., Turner, N. C., & Knudsen, E. S. (2015) · Nature Reviews Drug Discovery

Advanced Breast Cancer TherapiesCancer-related Molecular Pathways

Cited by 1,767

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

Witkiewicz, A. K., McMillan, E. A., Balaji, U., Baek, G., Lin, W.-C., Mansour, J., Mollaee, M., Wagner, K.-U., Koduru, P., Yopp, A., et al. (2015) · Nature Communications

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 1,115

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., et al. (2019) · Nature Medicine

Autophagy in Disease and TherapyPancreatic and Hepatic Oncology Research

Cited by 692

Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

Dean, J. L., Thangavel, C., McClendon, A. K., Reed, C. A., & Knudsen, E. S. (2010) · Oncogene

Advanced Breast Cancer TherapiesCancer-related Molecular Pathways

Cited by 393

Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer

Thangavel, C., Dean, J. L., Ertel, A., Knudsen, K. E., Aldaz, C. M., Witkiewicz, A. K., Clarke, R., & Knudsen, E. S. (2011) · Endocrine Related Cancer

Advanced Breast Cancer TherapiesEstrogen and related hormone effects

Cited by 302

The meaning of p16ink4aexpression in tumors: Functional significance, clinical associations and future developments

Witkiewicz, A. K., Knudsen, K. E., Dicker, A. P., & Knudsen, E. S. (2011) · Cell Cycle

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 286

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

Franco, J., Witkiewicz, A. K., & Knudsen, E. S. (2014) · Oncotarget

Pancreatic and Hepatic Oncology ResearchAdvanced Breast Cancer Therapies

Cited by 207

Metabolic reprogramming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities

Franco, J., Balaji, U., Freinkman, E., Witkiewicz, A. K., & Knudsen, E. S. (2016) · Cell Reports

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

Cited by 199

ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice

Casimiro, M. C., Crosariol, M., Loro, E., Ertel, A., Yu, Z., Dampier, W., Saria, E. A., Papanikolaou, A., Stanek, T. J., Li, Z., et al. (2012) · Journal of Clinical Investigation

Microtubule and mitosis dynamicsCancer-related Molecular Pathways

Cited by 115

Liver-Specific pRB Loss Results in Ectopic Cell Cycle Entry and Aberrant Ploidy

Mayhew, C. N., Bosco, E. E., Fox, S. R., Okaya, T., Tarapore, P., Schwemberger, S. J., Babcock, G. F., Lentsch, A. B., Fukasawa, K., & Knudsen, E. S. (2005) · Cancer Research

Cancer-related Molecular PathwaysLiver physiology and pathology

Cited by 101

Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer

Witkiewicz, A. K., Borja, N. A., Franco, J., Brody, J. R., Yeo, C. J., Mansour, J., Choti, M. A., McCue, P., & Knudsen, E. S. (2015) · Oncotarget

Pancreatic and Hepatic Oncology ResearchAdvanced Breast Cancer Therapies

Cited by 56

Loss of RB compromises specific heterochromatin modifications and modulates HP1α dynamics

Siddiqui, H., Fox, S. R., Gunawardena, R. W., & Knudsen, E. S. (2007) · Journal of Cellular Physiology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 47

The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress

Daria, D., Filippi, M.-D., Knudsen, E. S., Faccio, R., Li, Z., Kalfa, T., & Geiger, H. (2008) · Blood

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 46

RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors

Srinivasan, S. V., Mayhew, C. N., Schwemberger, S., Zagorski, W., & Knudsen, E. S. (2007) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 42