The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress

Osteoblastic cells regulate the haematopoietic stem cell niche

Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,433 · see citing works

Identification of the haematopoietic stem cell niche and control of the niche size

Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948 · see citing works

Effects of an Rb mutation in the mouse

Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755 · see citing works

Hematopoietic Stem Cell Quiescence Maintained by p21 ^cip1/waf1

Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339 · see citing works

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C., Herrup, K., Lee, W., & Bradley, A. (1992) · Nature · doi:10.1038/359288a0 · Cited by 1,264 · see citing works

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works

Requirement for a functional Rb-1 gene in murine development

Clarke, A. R., Maandag, E. R., van ROON, M. A., van der Lugt, N. M. T., van der Valk, M., Hooper, M., Berns, A. J. M., & Rielef, H. T. (1992) · Nature · doi:10.1038/359328a0 · Cited by 1,006 · see citing works

Induction of medulloblastomas in <i>p53</i> -null mutant mice by somatic inactivation of <i>Rb</i> in the external granular layer cells of the cerebellum

Marino, S., Vooijs, M., van der Gulden, H., Jonkers, J., & Berns, A. (2000) · Genes &amp; Development · doi:10.1101/gad.14.8.994 · Cited by 920 · see citing works

Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

Kollet, Ó., Dar, A., Shivtiel, S., Kalinkovich, A., Lapid, K., Sztainberg, Y., Tesio, M., Samstein, R. M., Goichberg, P., Spiegel, A., et al. (2006) · Nature Medicine · doi:10.1038/nm1417 · Cited by 774 · see citing works

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.Preprint

Zhu, L., van den Heuvel, S., Helin, K., Fattaey, A., Ewen, M. E., Livingston, D. M., Dyson, N. J., & Harlow, E. E. (1993) · Genes & Development · doi:10.1101/gad.7.7a.1111 · Cited by 516 · see citing works

Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment

Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E., & Orkin, S. H. (2007) · Cell · doi:10.1016/j.cell.2007.03.055 · Cited by 424 · see citing works

Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells

Bowman, T. V., Merchant, A. A., Ramos, C. A., Whitehouse, N. L., Young, A., Shaw, C. A., & Goodell, M. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020301 · Cited by 363 · see citing works

Stem cell repopulation efficiency but not pool size is governed by p27kip1

Cheng, T., Rodrigues, N. P., Dombkowski, D., Stier, S., & Scadden, D. T. (2000) · Nature Medicine · doi:10.1038/81335 · Cited by 347 · see citing works

Vav3 regulates osteoclast function and bone mass

Faccio, R., Teitelbaum, S., Fujikawa, K., Chappel, J., Zallone, A., Tybulewicz, V., Ross, F., & Swat, W. (2005) · Nature Medicine · doi:10.1038/nm1194 · Cited by 304 · see citing works

Phenotypic and Functional Changes Induced at the Clonal Level in Hematopoietic Stem Cells After 5-Fluorouracil Treatment

Randall, T. D., & Weissman, I. L. (1997) · Blood · doi:10.1182/blood.v89.10.3596 · Cited by 292 · see citing works

SOCS3 Is a Critical Physiological Negative Regulator of G-CSF Signaling and Emergency Granulopoiesis

Croker, B. A., Metcalf, D., Robb, L., Wei, W., Mifsud, S., DiRago, L., Cluse, L. A., Sutherland, K. D., Hartley, L., Williams, E., et al. (2004) · Immunity · doi:10.1016/s1074-7613(04)00022-6 · Cited by 285 · see citing works

Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma

Chen, D., Livne-bar, I., Vanderluit, J. L., Slack, R. S., Agochiya, M., & Bremner, R. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.05.025 · Cited by 281 · see citing works

Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization

Cancelas, J. A., Lee, A. W.-T., Prabhakar, R., Stringer, K. F., Zheng, Y., & Williams, D. A. (2005) · Nature Medicine · doi:10.1038/nm1274 · Cited by 274 · see citing works

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C

Yuan, Y., Shen, H., Franklin, D. S., Scadden, D. T., & Cheng, T. (2004) · Nature Cell Biology · doi:10.1038/ncb1126 · Cited by 269 · see citing works

vavCre Transgenic mice: A tool for mutagenesis in hematopoietic and endothelial lineages

Georgiades, P., Ogilvy, S., Duval, H., Licence, D. R., Jones, D. S., Smith, S. K., & Print, C. G. (2002) · genesis · doi:10.1002/gene.10161 · Cited by 234 · see citing works

Tumor suppressor genes in normal and malignant hematopoiesis

Krug, U. O., Ganser, A., & Koeffler, H. P. (2002) · Oncogene · doi:10.1038/sj.onc.1205322 · Cited by 229 · see citing works

Increased hematopoietic stem cell mobilization in aged mice

Xing, Z., Ryan, M. A., Daria, D., Nattamai, K., Zant, G. E. V., Wang, L., Zheng, Y., & Geiger, H. (2006) · Blood · doi:10.1182/blood-2005-12-010272 · Cited by 178 · see citing works

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages

Iavarone, A., King, E. R., Dai, X.-M., Leone, G. W., Stanley, E. R., & Lasorella, A. (2004) · Nature · doi:10.1038/nature03068 · Cited by 140 · see citing works

Essential role of retinoblastoma protein in mammalian hair cell development and hearing

Sage, C., Huang, M., Vollrath, M. A., Brown, M. C., Hinds, P. W., Corey, D. P., Vetter, D. E., & Chen, Z. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510631103 · Cited by 137 · see citing works

Homing and engraftment potential of Sca-1+lin− cells fractionated on the basis of adhesion molecule expression and position in cell cycle

Orschell, C. M., Hiatt, K. K., Dagher, R. N., Rice, S. E., Yöder, M. C., & Srour, E. F. (2000) · Blood · doi:10.1182/blood.v96.4.1380 · Cited by 133 · see citing works

Adhesion receptor expression by hematopoietic cell lines and murine progenitors

Becker, P. S., Nilsson, S. K., Li, Z., Berrios, V. M., Dooner, M. S., Cooper, C. L., Hsieh, C., & Quesenberry, P. J. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(98)00037-x · Cited by 132 · see citing works

RB, the conductor that orchestrates life, death and differentiation

Khidr, L., & Chen, P.-L. (2006) · Oncogene · doi:10.1038/sj.onc.1209612 · Cited by 123 · see citing works

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

Walkley, C. R., Fero, M. L., Chien, W., Purton, L. E., & McArthur, G. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1214 · Cited by 112 · see citing works

Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy

Geiger, H., True, J. M., de Haan, G., & Zant, G. E. V. (2001) · Blood · doi:10.1182/blood.v98.10.2966 · Cited by 103 · see citing works

The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice

Liang, Y., Jansen, M., Aronow, B. J., Geiger, H., & Zant, G. E. V. (2007) · Nature Genetics · doi:10.1038/ng1938 · Cited by 97 · see citing works

The Rb tumor suppressor is required for stress erythropoiesis

Spike, B. T., Dirlam, A., Dibling, B. C., Marvin, J., Williams, B. O., Jacks, T., & Macleod, K. F. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600432 · Cited by 92 · see citing works

Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells

Walkley, C. R., & Orkin, S. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603389103 · Cited by 71 · see citing works

A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress.

Stepanova, L., & Sorrentino, B. P. (2005) · Blood · doi:10.1182/blood-2004-06-2242 · Cited by 68 · see citing works

The retinoblastoma gene is involved in multiple aspects of stem cell biology

Galderisi, U., Cipollaro, M., & Giordano, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209736 · Cited by 61 · see citing works

Alterations of the cyclin D1/pRb/p16INK4A pathway in multiple myeloma

Krämer, A., Schultheis, B. S., Bergmann, J., Willer, A., Hegenbart, U., Ho, A. D., Goldschmidt, H., & Hehlmann, R. (2002) · Leukemia · doi:10.1038/sj.leu.2402609 · Cited by 59 · see citing works

Cell-intrinsic requirement for pRb in erythropoiesis

Clark, A. J., Doyle, K. M., & Humbert, P. O. (2004) · Blood · doi:10.1182/blood-2004-02-0618 · Cited by 55 · see citing works

The Rb network

DeGregori, J. V. (2004) · Journal of Cell Science · doi:10.1242/jcs.01189 · Cited by 54 · see citing works

Modulation of retinoblastoma gene in normal adult hematopoiesis: peak expression and functional role in advanced erythroid differentiation.

Condorelli, G., Testa, U., Valtieri, M., Vitelli, L., Luca, A. D., Barberi, T., Montesoro, E., Campisi, S., Giordano, A., & Peschle, C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4808 · Cited by 48 · see citing works

Active RB Elicits Late G1/S Inhibition

Angus, S. P., Fribourg, A. F., Markey, M. P., Williams, S., Horn, H. F., DeGregori, J. V., Kowalik, T. F., Fukasawa, K., & Knudsen, E. S. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5510 · Cited by 39 · see citing works

Involvement of the Retinoblastoma Protein in Monocytic and Neutrophilic Lineage Commitment of Human Bone Marrow Progenitor Cells

Bergh, G., Ehinger, M., Olsson, I., Jacobsen, S. E. W., & Gullberg, U. (1999) · Blood · doi:10.1182/blood.v94.6.1971 · Cited by 36 · see citing works

Retinoblastoma gene deficiency has mitogenic but not tumorigenic effects on erythropoiesis.

Hu, N., Gulley, M. L., Kung, J. T., & Lee, E. Y. (1997) · PubMed · Cited by 28 · see citing works

The Rb Tumor Suppressor in Stress Responses and Hematopoietic Homeostasis

Spike, B. T., & Macleod, K. F. (2004) · Cell Cycle · doi:10.4161/cc.4.1.1337 · Cited by 23 · see citing works

Hematopoietic reserve provided by spleen colony-forming units (CFU-S).

Nečas, E., Šefc, L., Brecher, G., et al. (1995) · PubMed · Cited by 14 · see citing works

Cellular mechanisms of tumour suppression by the retinoblastoma gene

Burkhart, D. L., & Sage, J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2399 · Cited by 974 · see citing works

p57 is required for quiescence and maintenance of adult hematopoietic stem cells

Matsumoto, A., Takeishi, S., Kanie, T., Susaki, E., Onoyama, I., Tateishi, Y., Nakayama, K., & Nakayama, K. I. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.06.014 · Cited by 329 · see citing works

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

Florian, M. C., Nattamai, K. J., Dörr, K., Marka, G., Überle, B., Vas, V., Eckl, C., Andrä, I., Schiemann, M., Oostendorp, R. A. J., et al. (2013) · Nature · doi:10.1038/nature12631 · Cited by 303 · see citing works

Hematopoietic Stem Cell Quiescence Is Maintained by Compound Contributions of the Retinoblastoma Gene Family

Viatour, P., Somervaille, T. C., Venkatasubrahmanyam, S., Kogan, S., McLaughlin, M. E., Weissman, I. L., Butte, A. J., Passegué, E., & Sage, J. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.009 · Cited by 178 · see citing works

Aging of the microenvironment influences clonality in hematopoiesis

Vas, V., Senger, K., Dörr, K., Niebel, A., & Geiger, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042080 · Cited by 83 · see citing works

Cytoplasmatic Expression of CD34 in Acute Leukemia

Uhr, M., Tamasy, P., & Cavalli, F. (1998) · Hämatologie und Bluttransfusion · doi:10.1007/978-3-642-71960-8_7

Progenitor cells and circulating endothelial cells are associated with disease activity and damage in systemic lupus erythematosus patientsPreprint

Silveira, G., Ranero, S., Carlomagno, A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3706927/v1

1015 – HUMAN HAEMATOPOIETIC STEM AND PROGENITOR CELL LANDSCAPES: LOCATION MATTERS

Laurenti, E., Bastos, H. P., & Mende, N. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.09.014

Differential MMP-9 activity in CD34+progenitor cell-derived foam cells from diabetic and normoglycemic patients

Schmohl, J., Daub, K., von Ungern‐Sternberg, S. N. I., et al. (2013) · Herz · doi:10.1007/s00059-013-4012-y

Lifelong multilineage contribution by embryonic-born blood progenitors

Patel, S. H., Christodoulou, C., Weinreb, C., Yu, Q., da Rocha, E. L., Pepe-Mooney, B. J., Bowling, S., Li, L., Osorio, F. G., Daley, G. Q., et al. (2022) · Nature · doi:10.1038/s41586-022-04804-z · Cited by 170 · see citing works