Tontonoz, Peter

Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77

Chao, L. C., Wroblewski, K., Zhang, Z., Pei, L., Vergnes, L., Ilkayeva, O. R., Ding, S. Y., Reue, K., Watt, M. J., Newgard, C. B., et al. (2009) · Diabetes

Nuclear Receptors and SignalingMetabolism, Diabetes, and Cancer

Cited by 154

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2

Hong, C., Duit, S., Jalonen, P., Out, R., Scheer, L., Sorrentino, V., Boyadjian, R., Rodenburg, K. W., Foley, E., Korhonen, L., et al. (2010) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismUbiquitin and proteasome pathways

Cited by 142

Feedback Regulation of Cholesterol Uptake by the LXR–IDOL–LDLR Axis

Zhang, L., Reue, K., Fong, L. G., Young, S. G., & Tontonoz, P. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 137

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease

Beaven, S. W., Wroblewski, K., Wang, J., Hong, C., Bensinger, S., Tsukamoto, H., & Tontonoz, P. (2011) · Gastroenterology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 131

Hepatic transcriptional responses to fasting and feeding

Bideyan, L., Nagari, R., & Tontonoz, P. (2021) · Genes & Development

Dietary Effects on HealthCircadian rhythm and melatonin

Cited by 126

MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

Hamada, M., Nakamura, M., Tran, M. T. N., Moriguchi, T., Hong, C., Ohsumi, T., Dinh, T. T. H., Kusakabe, M., Hattori, M., Katsumata, T., et al. (2014) · Nature Communications

Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

Cited by 111

The LXR–Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice

Hong, C., Marshall, S. M., McDaniel, A. L., Graham, M., Layne, J. D., Cai, L., Scotti, E., Boyadjian, R., Kim, J., Chamberlain, B. T., et al. (2014) · Cell Metabolism

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 87

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

Zhang, L., Fairall, L., Goult, B. T., Calkin, A. C., Hong, C., Millard, C. J., Tontonoz, P., & Schwabe, J. W. R. (2011) · Genes & Development

Ubiquitin and proteasome pathwaysCholesterol and Lipid Metabolism

Cited by 86

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

Seldin, M. M., Koplev, S., Rajbhandari, P., Vergnes, L., Rosenberg, G. M., Meng, Y., Pan, C., Phuong, T. M. N., Gharakhanian, R., Che, N., et al. (2018) · Cell Metabolism

Adipose Tissue and MetabolismBioinformatics and Genomic Networks

Cited by 84

IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

Scotti, E., Calamai, M., Goulbourne, C. N., Zhang, L., Hong, C., Lin, R. R., Choi, J., Pilch, P. F., Fong, L. G., Zou, P., et al. (2013) · Molecular and Cellular Biology

Cellular transport and secretionCholesterol and Lipid Metabolism

Cited by 81

Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists

Scotti, E., Hong, C., Yoshinaga, Y., Tu, Y., Hu, Y., Zelcer, N., Boyadjian, R., de Jong, P. J., Young, S. G., Fong, L. G., et al. (2011) · Molecular and Cellular Biology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 77

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

Zhang, L., Rajbhandari, P., Priest, C., Sandhu, J., Wu, X., Temel, R., Castrillo, A., de Aguiar Vallim, T. Q., Sallam, T., & Tontonoz, P. (2017) · eLife

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 69

The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans

Weissglas-Volkov, D., Calkin, A. C., Tusie-Luna, T., Sinsheimer, J. S., Zelcer, N., Riba, L., Tino, A. M. V., Ordoñez-Sánchez, M. L., Cruz-Bautista, I., Aguilar-Salinas, C. A., et al. (2011) · Journal of Clinical Investigation

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 66

Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane

Ferrari, A., He, C., Kennelly, J. P., Sandhu, J., Xiao, X., Chi, X., Jiang, H., Young, S. G., & Tontonoz, P. (2020) · Molecular and Cellular Biology

Cholesterol and Lipid MetabolismLipid Membrane Structure and Behavior

Cited by 66

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

Calkin, A. C., Goult, B. T., Zhang, L., Fairall, L., Hong, C., Schwabe, J. W. R., & Tontonoz, P. (2011) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysCholesterol and Lipid Metabolism

Cited by 62

Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake

Ferrari, A., Whang, E., Xiao, X., Kennelly, J. P., Romartinez-Alonso, B., Mack, J. J., Weston, T., Chen, K., Kim, Y., Tol, M. J., et al. (2023) · Science

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 61

The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis

Choi, J., Gao, J., Kim, J., Hong, C., Kim, J., & Tontonoz, P. (2015) · Science Translational Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 49

LDL Receptor Pathway Regulation by miR-224 and miR-520d

Salerno, A. G., van Solingen, C., Scotti, E., Wanschel, A. C. B. A., Afonso, M. S., Oldebeken, S. R., Spiro, W., Tontonoz, P., Rayner, K. J., & Moore, K. J. (2020) · Frontiers in Cardiovascular Medicine

MicroRNA in disease regulationCholesterol and Lipid Metabolism

Cited by 33

The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

Gao, J., Marosi, M., Choi, J., Achiro, J. M., Kim, S., Li, S., Otis, K., Martin, K. C., Portera-Cailliau, C., & Tontonoz, P. (2017) · eLife

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

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The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis

Sallam, T., Ito, A., Rong, X., Kim, J., van Stijn, C., Chamberlain, B. T., Jung, M. E., Chao, L. C., Jones, M., Gilliland, T., et al. (2014) · Journal of Lipid Research

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 30

IDOL regulates systemic energy balance through control of neuronal VLDLR expression

Lee, S. D., Priest, C., Bjursell, M., Gao, J., Arneson, D. V., Ahn, I. S., Diamante, G., van Veen, J. E., Massa, M. G., Calkin, A. C., et al. (2019) · Nature Metabolism

Regulation of Appetite and ObesityCholesterol and Lipid Metabolism

Cited by 26

Defining the Cell Surface Cysteinome using Two-step Enrichment Proteomics

Yan, T., Boatner, L. M., Cui, L., Tontonoz, P., & Backus, K. M. (2023) · JACS Au

Redox biology and oxidative stressAdvanced Proteomics Techniques and Applications

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Therapeutic Idol reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice

Gao, J., Littman, R., Diamante, G., Xiao, X., Ahn, I. S., Yang, X., Cole, T. A., & Tontonoz, P. (2020) · Molecular and Cellular Biology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 15