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Cited by 126Dietary Effects on HealthCircadian rhythm and melatoninMetabolism, Diabetes, and Cancer

Hepatic transcriptional responses to fasting and feeding

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Bideyan, Lara, Nagari, Rohith, Tontonoz, Peter·2021·Genes & Development
DOI 10.1101/gad.348340.121PMC PMC8091980
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Abstract

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional responses in metabolic tissues. Here we review advances in our understanding of the gene regulatory networks that contribute to hepatic responses to fasting and feeding. The advent of sequencing and -omics techniques have begun to facilitate a holistic understanding of the transcriptional landscape and its plasticity. We highlight transcription factors, their cofactors, and the pathways that they impact. We also discuss physiological factors that impinge on these responses, including circadian rhythms and sex differences. Finally, we review how dietary modifications modulate hepatic gene expression programs.

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  • Many additional transcription factors beyond the hepatic identity core transcriptional regulatory circuitry transcription factors have been ascribed roles in the control of hepatocyte activities.

    “many additional TFs beyond these hepatic identity CoRC TFs have been ascribed with roles in the control of hepatocyte activities (Bideyan et al, 2021).”

    From An extended transcription factor regulatory network controls hepatocyte identity (2023) · cites this paper as Bideyan et al, 2021

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Cited by

Sorted by citations

Authors
Bideyan, L., Nagari, R., & Tontonoz, P.
Affiliations
University of California, Los Angeles (US)
ORCID
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2021-04-22
Volume
35
Issue
9-10
Pages
635-657
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.348340.121
PMC
PMC8091980
OpenAlex
W3154074369
Cited by
126
References
19
Citations by year
2026: 23 · 2025: 23 · 2024: 26 · 2023: 33 · 2022: 21
Type
posted content
Language
en
Open access
Licence
cc-by-nc
Locations
  • Genes & Development (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
fasting, feeding, hepatic gene expression, transcriptional regulation, gene regulatory networks, transcription factors, transcriptional cofactors, circadian rhythm, sex differences, dietary modulation, metabolic tissues
MeSH terms
Animals, Circadian Rhythm, Eating, Fasting, Gene Expression Regulation, Humans, Liver, Sex Factors, Transcription Factors, Gene Regulatory Networks

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