Tontonoz, Peter

Fat and Beyond: The Diverse Biology of PPARγ

Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 2,085

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

Chawla, A., Boisvert, W. A., Lee, C.-H., Laffitte, B. A., Barak, Y., Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss, L. K., et al. (2001) · Molecular Cell

Cholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 1,347

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J., & Tontonoz, P. (2003) · Nature Medicine

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 1,158

PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., & Evans, R. M. (2001) · Nature Medicine

Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

Cited by 1,069

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα

Venkateswaran, A., Laffitte, B. A., Joseph, S. B., Mak, P. A., Wilpitz, D. C., Edwards, P. A., & Tontonoz, P. (2000) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 1,005

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., & Edwards, P. A. (2002) · Journal of Biological Chemistry

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 916

ApoE Promotes the Proteolytic Degradation of Aβ

Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 876

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

Zelcer, N., Hong, C., Boyadjian, R., & Tontonoz, P. (2009) · Science

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 848

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

Calkin, A. C., & Tontonoz, P. (2012) · Nature Reviews Molecular Cell Biology

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 779

Liver X receptors in lipid signalling and membrane homeostasis

Wang, B., & Tontonoz, P. (2018) · Nature Reviews Endocrinology

Cholesterol and Lipid MetabolismLipid Membrane Structure and Behavior

Cited by 722

LXR signaling couples sterol metabolism to proliferation in the acquired immune response

Bensinger, S. J., Bradley, M. N., Joseph, S. B., Zelcer, N., Janssen, E. M., Hausner, M. A., Shih, R., Parks, J. S., Edwards, P. A., Jamieson, B. D., et al. (2008) · Cell

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 711

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

Laffitte, B. A., Repa, J. J., Joseph, S. B., Wilpitz, D. C., Kast, H. R., Mangelsdorf, D. J., & Tontonoz, P. (2001) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 683

Liver X receptors in lipid metabolism: opportunities for drug discovery

Hong, C., & Tontonoz, P. (2014) · Nature Reviews Drug Discovery

Cholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 587

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

Guo, D., Reinitz, F., Youssef, M., Hong, C., Nathanson, D., Akhavan, D., Kuga, D., Amzajerdi, A. N., Soto, H., Zhu, S., et al. (2011) · Cancer Discovery

Cancer, Lipids, and MetabolismGlioma Diagnosis and Treatment

Cited by 452

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

Warrier, M., Shih, D. M., Burrows, A. C., Ferguson, D., Gromovsky, A. D., Brown, A. L., Marshall, S., McDaniel, A., Schugar, R. C., Wang, Z., et al. (2015) · Cell Reports

Cholesterol and Lipid MetabolismGut microbiota and health

Cited by 414

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

Zelcer, N., Khanlou, N., Clare, R., Jiang, Q., Reed-Geaghan, E. G., Landreth, G. E., Vinters, H. V., & Tontonoz, P. (2007) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 358

The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice

Chen, X., McClusky, R., Chen, J., Beaven, S. W., Tontonoz, P., Arnold, A. P., & Reue, K. (2012) · PLoS Genetics

Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesRegulation of Appetite and Obesity

Cited by 326

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

Sandhu, J., Li, S., Fairall, L., Pfisterer, S. G., Gurnett, J. E., Xiao, X., Weston, T. A., Vashi, D., Ferrari, A., Orozco, J. L., et al. (2018) · Cell

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 287

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

Ito, A., Hong, C., Rong, X., Zhu, X., Tarling, E. J., Hedde, P. N., Gratton, E., Parks, J., & Tontonoz, P. (2015) · eLife

Cholesterol and Lipid MetabolismImmune Response and Inflammation

Cited by 281

Inter-organ cross-talk in metabolic syndrome

Priest, C., & Tontonoz, P. (2019) · Nature Metabolism

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 279

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Ribas, V., Drew, B. G., Zhou, Z., Phun, J., Kalajian, N. Y., Soleymani, T., Daraei, P., Widjaja, K., Wanagat, J., de Aguiar Vallim, T. Q., et al. (2016) · Science Translational Medicine

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 259

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

Hong, C., & Tontonoz, P. (2008) · Current Opinion in Genetics & Development

Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

Cited by 253

Genetic Architecture of Insulin Resistance in the Mouse

Parks, B. W., Sallam, T., Mehrabian, M., Psychogios, N., Hui, S. T., Norheim, F., Castellani, L. W., Rau, C. D., Pan, C., Phun, J., et al. (2015) · Cell Metabolism

Genetic Mapping and Diversity in Plants and AnimalsGenetic Associations and Epidemiology

Cited by 249

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., et al. (2020) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 204