Scheffner, Martin

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell

Cancer-related Molecular PathwaysCervical Cancer and HPV Research

Cited by 3,995

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

Huibregtse, J. M., Scheffner, M., & Howley, P. M. (1991) · The EMBO Journal

Cancer-related Molecular PathwaysCervical Cancer and HPV Research

Cited by 879

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

Linares, L. K., Hengstermann, A., Ciechanover, A., Müller, S., & Scheffner, M. (2003) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 361

The ubiquitin‐protein ligase E6‐associated protein (E6‐AP) serves as its own substrate

Nuber, U., Schwarz, S. E., & Scheffner, M. (1998) · European Journal of Biochemistry

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 128

Poly(ADP‐ribose)‐mediated interplay of XPA and PARP 1 leads to reciprocal regulation of protein function

Fischer, J. M. F., Popp, O., Gebhard, D., Veith, S., Fischbach, A., Beneke, S., Leitenstorfer, A., Bergemann, J., Scheffner, M., Ferrando‐May, E., et al. (2014) · The FEBS Journal

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 72

Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells

Kienle, S. M., Sigg, M., Schneider, T., Stuber, K., Lehmann, J., Jansen, J., Stengel, F., Marx, A., Kovermann, M., & Scheffner, M. (2025) · Nature Communications

RNA and protein synthesis mechanismsUbiquitin and proteasome pathways

Cited by 0

Non-hydrolyzable acetyllysine analogs to study protein acetylation in vitro and in cells

Kienle, S. M., Sigg, M., Schneider, T., Stuber, K., Lehmann, J., Jansen, J., Stengel, F., Marx, A., Kovermann, M., & Scheffner, M. (2026) · Nature Communications

RNA and protein synthesis mechanismsUbiquitin and proteasome pathways

Cited by 0