Fearnley, Ian M.

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

Chouchani, E. T., Methner, C., Nadtochiy, S. M., Logan, A., Pell, V. R., Ding, S., James, A. M., Cochemé, H. M., Reinhold, J., Lilley, K. S., et al. (2013) · Nature Medicine

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 619

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Cochemé, H. M., Quin, C., McQuaker, S. J., Cabreiro, F., Logan, A., Prime, T. A., Abakumova, I., Patel, J. V., Fearnley, I. M., James, A. M., et al. (2011) · Cell Metabolism

Redox biology and oxidative stressGenetics, Aging, and Longevity in Model Organisms

Cited by 313

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

He, J., Ford, H. C., Carroll, J., Ding, S., Fearnley, I. M., & Walker, J. E. (2017) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 251

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice

Rodriguez-Cuenca, S., Cochemé, H. M., Logan, A., Abakumova, I., Prime, T. A., Rose, C., Vidal-Puig, A., Smith, A. C., Rubinsztein, D. C., Fearnley, I. M., et al. (2010) · Free Radical Biology and Medicine

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 218

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

He, J., Carroll, J., Ding, S., Fearnley, I. M., & Walker, J. E. (2017) · Proceedings of the National Academy of Sciences

ATP Synthase and ATPases ResearchMitochondrial Function and Pathology

Cited by 182

Complex I within Oxidatively Stressed Bovine Heart Mitochondria Is Glutathionylated on Cys-531 and Cys-704 of the 75-kDa Subunit

Hurd, T. R., Requejo, R., Filipovska, A., Brown, S., Prime, T. A., Robinson, A. J., Fearnley, I. M., & Murphy, M. P. (2008) · Journal of Biological Chemistry

Redox biology and oxidative stressMitochondrial Function and Pathology

Cited by 182

SIRT3 Deacetylates ATP Synthase F 1 Complex Proteins in Response to Nutrient- and Exercise-Induced Stress

Vassilopoulos, A., Pennington, J. D., Andresson, T., Rees, D. M., Bosley, A. D., Fearnley, I. M., Ham, A., Flynn, C. R., Hill, S., Rose, K. L., et al. (2014) · Antioxidants & Redox Signaling

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

Cited by 173

Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation

Chouchani, E. T., Hurd, T. R., Nadtochiy, S. M., Brookes, P. S., Fearnley, I. M., Lilley, K. S., Smith, R. A. J., & Murphy, M. P. (2010) · Biochemical Journal

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 137

Non-enzymatic N-acetylation of lysine residues by acetylCoA often occurs via a proximal S-acetylated thiol intermediate sensitive to glyoxalase II

James, A. M., Hoogewijs, K., Logan, A., Hall, A. R., Ding, S., Fearnley, I. M., & Murphy, M. P. (2017) · Cell Reports

Sirtuins and Resveratrol in MedicineRedox biology and oxidative stress

Cited by 112

Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations

Liao, C., Ashley, N., Diot, A., Morten, K., Phadwal, K., Williams, A., Fearnley, I., Rosser, L., Lowndes, J., Fratter, C., et al. (2017) · Neurology

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 97

TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I

Carroll, J., He, J., Ding, S., Fearnley, I. M., & Walker, J. E. (2021) · Proceedings of the National Academy of Sciences

ATP Synthase and ATPases ResearchMitochondrial Function and Pathology

Cited by 46

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Tavoulari, S., Schirris, T. J. J., Mavridou, V., Thangaratnarajah, C., King, M. S., Jones, D. T. D., Ding, S., Fearnley, I. M., & Kunji, E. R. S. (2022) · Molecular Metabolism

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 38