Scheffzek, Klaus

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmüller, L., Lautwein, A., Schmitz, F., & Wittinghofer, A. (1997) · Science

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 1,543

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

Timinszky, G., Till, S., Hassa, P. O., Hothorn, M., Kustatscher, G., Nijmeijer, B., Colombelli, J., Altmeyer, M., Stelzer, E. H. K., Scheffzek, K., et al. (2009) · Nature Structural & Molecular Biology

Genomics and Chromatin DynamicsDNA Repair Mechanisms

Cited by 416

GTPase-activating proteins: Helping hands to complement an active site

Scheffzek, K., Ahmadian, M. R., & Wittinghofer, A. (1998) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 410

Mutations in SYNGAP1 Cause Intellectual Disability, Autism, and a Specific Form of Epilepsy by Inducing Haploinsufficiency

Berryer, M. H., Hamdan, F. F., Klitten, L. L., Møller, R. S., Carmant, L., Schwartzentruber, J., Patry, L., Dobrzeniecka, S., Rochefort, D., Neugnot-Cerioli, M., et al. (2013) · Human Mutation

Genetics and Neurodevelopmental DisordersGenomics and Rare Diseases

Cited by 266

The interaction of Ras with GTPase‐activating proteins

Wittinghofer, A., Scheffzek, K., & Ahmadian, M. R. (1997) · FEBS Letters

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 135

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling

de Araujo, M. E. G., Naschberger, A., Fürnrohr, B. G., Stasyk, T., Dunzendorfer-Matt, T., Lechner, S., Welti, S., Kremser, L., Shivalingaiah, G., Offterdinger, M., et al. (2017) · Science

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 134

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning

Filipek, P. A., de Araujo, M. E. G., Vogel, G. F., De Smet, C. H., Eberharter, D., Rebsamen, M., Rudashevskaya, E. L., Kremser, L., Yordanov, T., Tschaikner, P., et al. (2017) · Journal of Cell Biology

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 119

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

Pena, V., Hothorn, M., Eberth, A., Kaschau, N., Parret, A., Gremer, L., Bonneau, F., Ahmadian, M. R., & Scheffzek, K. (2008) · The EMBO Reports

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 101

Observation of slow dynamic exchange processes in RAS protein crystals by 31P solid state NMR spectroscopy

Stumber, M., Geyer, M., Graf, R., Robert Kalbitzer, H., Scheffzek, K., & Haeberlen, U. (2002) · Journal of Molecular Biology

Advanced NMR Techniques and ApplicationsElectron Spin Resonance Studies

Cited by 22