Christofk, Heather R.

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

Christofk, H. R., Vander Heiden, M. G., Wu, N., Asara, J. M., & Cantley, L. C. (2008) · Nature

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 995

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Anastasiou, D., Yu, Y., Israelsen, W. J., Jiang, J.-K., Boxer, M. B., Hong, B. S., Tempel, W., Dimov, S., Shen, M., Jha, A., et al. (2012) · Nature Chemical Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 816

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

Krall, A. S., Xu, S., Graeber, T. G., Braas, D., & Christofk, H. R. (2016) · Nature Communications

Amino Acid Enzymes and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 504

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

Schell, J. C., Wisidagama, D. R., Bensard, C., Zhao, H., Wei, P., Tanner, J., Flores, A., Mohlman, J., Sorensen, L. K., Earl, C. S., et al. (2017) · Nature Cell Biology

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 322

Lactate dehydrogenase activity drives hair follicle stem cell activation

Flores, A., Schell, J., Krall, A. S., Jelinek, D., Miranda, M., Grigorian, M., Braas, D., White, A. C., Zhou, J. L., Graham, N. A., et al. (2017) · Nature Cell Biology

Hair Growth and DisordersCancer, Hypoxia, and Metabolism

Cited by 301

Histone Acetylation Regulates Intracellular pH

McBrian, M. A., Behbahan, I. S., Ferrari, R., Su, T., Huang, T.-W., Li, K., Hong, C. S., Christofk, H. R., Vogelauer, M., Seligson, D. B., et al. (2013) · Molecular Cell

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 272

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

Momcilovic, M., Jones, A., Bailey, S. T., Waldmann, C. M., Li, R., Lee, J. T., Abdelhady, G., Gomez, A., Holloway, T., Schmid, E., et al. (2019) · Nature

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

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Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

Nakano, H., Minami, I., Braas, D., Pappoe, H., Wu, X., Sagadevan, A., Vergnes, L., Fu, K., Morselli, M., Dunham, C., et al. (2017) · eLife

Congenital heart defects researchPluripotent Stem Cells Research

Cited by 195

Targeted inhibition of EGFR and glutaminase induces metabolic crisis in EGFR mutant lung cancer

Momcilovic, M., Bailey, S. T., Lee, J. T., Fishbein, M. C., Magyar, C., Braas, D., Graeber, T., Jackson, N. J., Czernin, J., Emberley, E., et al. (2017) · Cell Reports

Cancer, Hypoxia, and MetabolismLung Cancer Treatments and Mutations

Cited by 157

Metabolic regulation of tissue stem cells

Shapira, S. N., & Christofk, H. R. (2020) · Trends in Cell Biology

Metabolism, Diabetes, and CancerDevelopmental Biology and Gene Regulation

Cited by 82

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Halbrook, C. J., Thurston, G., Boyer, S., Anaraki, C., Jiménez, J. A., McCarthy, A., Steele, N. G., Kerk, S. A., Hong, H. S., Lin, L., et al. (2022) · Nature Cancer

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 80

Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth

Krall, A. S., Mullen, P. J., Surjono, F., Momcilovic, M., Schmid, E. W., Halbrook, C. J., Thambundit, A., Mittelman, S. D., Lyssiotis, C. A., Shackelford, D. B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory)

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

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