Metabolic regulation of tissue stem cells
Open accessAbstract
Adult tissue stem cells mediate organ homeostasis and regeneration and thus are continually making decisions about whether to remain quiescent, proliferate, or differentiate into mature cell types. These decisions often integrate external cues, such as energy balance and the nutritional status of the organism. Metabolic substrates and byproducts that regulate epigenetic and signaling pathways are now appreciated to have instructive rather than bystander roles in regulating cell fate decisions. In this review, we highlight recent literature focused on how metabolites and dietary manipulations can impact cell fate decisions, with a focus on the regulation of adult tissue stem cells.
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In multiple tissue contexts, adult stem cells primarily engage in aerobic glycolysis.
“In multiple tissue contexts, adult stem cells have been found to primarily engage in aerobic glycolysis.”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [204]
Upon lineage commitment and differentiation, cells increase their oxidation of pyruvate in the TCA cycle and display enhanced OXPHOS.
“Upon lineage commitment and differentiation, however, cells increase their oxidation of pyruvate in the TCA cycle and display enhanced OXPHOS (203, 204, 205).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [204]
Myogenic differentiation is coupled with increased pyruvate oxidation and OXPHOS, and this metabolic shift is likely driven, in part, by the significant energy demands of skeletal muscle.
“Myogenic differentiation is also coupled with increased pyruvate oxidation and OXPHOS, and this metabolic shift is likely driven, in part, by the significant energy demands of skeletal muscle (121, 204, 209).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [204]
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- Authors
- Shapira, S. N., & Christofk, H. R.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Christofk, Heather R.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 30
- Issue
- 7
- Pages
- 566-576
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC8059102
- OpenAlex
- W3022850946
- Cited by
- 82
- References
- 89
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 19 · 2023: 18 · 2022: 13 · 2021: 15 · 2020: 4
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Cancer Society
- National Institutes of Health
- Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles
- Jonsson Comprehensive Cancer Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- tissue stem cells, metabolic regulation, cell fate determination, stem cell quiescence, stem cell proliferation, stem cell differentiation, energy balance, nutritional status, dietary intervention, metabolites, epigenetic regulation, signaling pathways, organ homeostasis, tissue regeneration
- MeSH terms
- Animals, Diet, Homeostasis, Humans, Neoplasms, Organ Specificity, Stem Cells, Epigenesis, Genetic
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