Histone Acetylation Regulates Intracellular pH

McBrian, Matthew A.; Behbahan, Iman Saramipoor; Ferrari, Roberto; Su, Trent; Huang, Ta-Wei; Li, Kunwu; Hong, Candice S.; Christofk, Heather R.; Vogelauer, Maria; Seligson, David B.; Kurdistani, Siavash K.

doi:10.1016/j.molcel.2012.10.025

Cited by 272Histone Deacetylase Inhibitors ResearchGenomics and Chromatin DynamicsEpigenetics and DNA Methylation

Histone Acetylation Regulates Intracellular pH

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McBrian, Matthew A., Behbahan, Iman Saramipoor, Ferrari, Roberto, Su, Trent, Huang, Ta-Wei, Li, Kunwu, Hong, Candice S., Christofk, Heather R. +3 more·2013·Molecular Cell

DOI 10.1016/j.molcel.2012.10.025PMC PMC3893119

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Abstract

Differences in global levels of histone acetylation occur in normal and cancer cells, although the reason why cells regulate these levels has been unclear. Here we demonstrate a role for histone acetylation in regulating intracellular pH (pH(i)). As pH(i) decreases, histones are globally deacetylated by histone deacetylases (HDACs), and the released acetate anions are coexported with protons out of the cell by monocarboxylate transporters (MCTs), preventing further reductions in pH(i). Conversely, global histone acetylation increases as pH(i) rises, such as when resting cells are induced to proliferate. Inhibition of HDACs or MCTs decreases acetate export and lowers pH(i), particularly compromising pH(i) maintenance in acidic environments. Global deacetylation at low pH is reflected at a genomic level by decreased abundance and extensive redistribution of acetylation throughout the genome. Thus, acetylation of chromatin functions as a rheostat to regulate pH(i) with important implications for mechanism of action and therapeutic use of HDAC inhibitors.

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Cells are capable of buffering against extracellular reductions in pH to maintain alkaline pH of the cytoplasm.
“Cells are capable of buffering against extracellular reductions in pH to maintain alkaline pH of the cytoplasm (Johnson et al., 1976; L’allemain et al., 1984; Lindström and Sehlin, 1984; Pouyssegur et al., 1985; McBrian et al., 2013).”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as McBrian et al., 2013
The Discussion says cells regulate intracellular pH in response to extracellular pH changes, and the Introduction describes proton export that resists further intracellular acidification. But the Results report that intracellular pH fell as extracellular pH fell, reaching 6.3; the paper does not establish that cells generally maintain an alkaline cytoplasm under those conditions. The Discussion presents alkaline intracellular pH in acidic cancer environments as a possibility. (LLM, conf=0.83)
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Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,477 · see citing works
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works
Sensors and regulators of intracellular pH
Casey, J. R., Grinstein, S., & Orlowski, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2820 · Cited by 2,276 · see citing works
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
Fraga, M. F., Ballestar, E., Villar‐Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C. E., Ropero, S., Petrie, K. R., et al. (2005) · Nature Genetics · doi:10.1038/ng1531 · Cited by 1,926 · see citing works
Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions
Shogren‐Knaak, M. A., Ishii, H., Sun, J.-M., Pazin, M. J., Davie, J., & Peterson, C. L. (2006) · Science · doi:10.1126/science.1124000 · Cited by 1,876 · see citing works
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
Taverna, S. D., Li, H., Ruthenburg, A. J., Allis, C. D., & Patel, D. J. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1338 · Cited by 1,419 · see citing works
Charting histone modifications and the functional organization of mammalian genomes
Zhou, V. W., Goren, A., & Bernstein, B. E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2905 · Cited by 1,147 · see citing works
Global histone modification patterns predict risk of prostate cancer recurrence
Seligson, D. B., Horvath, S., Shi, T., Yu, H., Tze, S., Grunstein, M. R., & Kurdistani, S. K. (2005) · Nature · doi:10.1038/nature03672 · Cited by 1,090 · see citing works
Self-citation
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Halestrap, A. P., & Meredith, D. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1067-2 · Cited by 1,047 · see citing works
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
Cardone, R. A., Casavola, V., & Reshkin, S. J. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1713 · Cited by 897 · see citing works
The key to development: interpreting the histone code?
Margueron, R., Trojer, P., & Reinberg, D. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.01.005 · Cited by 747 · see citing works
Acidic Extracellular pH Promotes Experimental Metastasis of Human Melanoma Cells in Athymic Nude Mice
Rofstad, E. K., Mathiesen, B. S., Kindem, K., & Galappathi, K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0983 · Cited by 668 · see citing works
Tumor pH and Its Measurement
Zhang, X., Lin, Y., & Gillies, R. J. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.068981 · Cited by 659 · see citing works
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Seligson, D. B., Horvath, S., McBrian, M. A., Mah, V. H., Yu, H., Tze, S., Wang, Q., Chia, D., Goodglick, L., & Kurdistani, S. K. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080874 · Cited by 511 · see citing works
Self-citation
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Elsheikh, S. E., Green, A. R., Rakha, E. A., Powe, D. G., Ahmed, R. A., Collins, H. M., Soria, D., Garibaldi, J. M., Paish, C. E., Ammar, A. A., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3907 · Cited by 510 · see citing works
Global histone acetylation and deacetylation in yeast
Vogelauer, M., Wu, J., Suka, N., & Grunstein, M. R. (2000) · Nature · doi:10.1038/35044127 · Cited by 452 · see citing works
Self-citation
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription
Takahashi, H., McCaffery, J. M., Irizarry, R. A., & Boeke, J. D. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.040 · Cited by 438 · see citing works
T cell stimulation and expansion using anti-CD3/CD28 beads
Trickett, A. E., & Kwan, Y. L. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(03)00010-3 · Cited by 381 · see citing works
Na + /H + exchanger‐dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation‐associated phenotypes
Reshkin, S. J., Bellizzi, A., Caldeira, S., Albarani, V., Malanchi, I., Poignee, M., Alunni‐Fabbroni, M., Casavola, V., & Tommasino, M. (2000) · The FASEB Journal · doi:10.1096/fj.00-0029com · Cited by 366 · see citing works
pH control mechanisms of tumor survival and growth
Parks, S. K., Chiche, J., & Pouysségur, J. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22400 · Cited by 356 · see citing works
The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin—one single nature
Harguindey, S., Orive, G., Pedraz, J. L., Paradiso, A., & Reshkin, S. J. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.06.004 · Cited by 240 · see citing works
Monocarboxylic acid permeation through lipid bilayer membranes
Walter, A., & Gutknecht, J. (1984) · The Journal of Membrane Biology · doi:10.1007/bf01870573 · Cited by 235 · see citing works
Reducing Time and Increasing Sensitivity in Sample Preparation for Adherent Mammalian Cell Metabolomics
Lorenz, M. A., Burant, C., & Kennedy, R. T. (2011) · Analytical Chemistry · doi:10.1021/ac103313x · Cited by 233 · see citing works
Cellular Histone Modification Patterns Predict Prognosis and Treatment Response in Resectable Pancreatic Adenocarcinoma: Results From RTOG 9704
Manuyakorn, A., Paulus, R., Farrell, J. J., Dawson, N. A., Tze, S., Cheung-Lau, G. C., Hines, O. J., Reber, H. A., Seligson, D. B., Horvath, S., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.5639 · Cited by 216 · see citing works
Self-citation
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Horwitz, G. A., Zhang, K., McBrian, M. A., Grunstein, M. R., Kurdistani, S. K., & Berk, A. J. (2008) · Science · doi:10.1126/science.1155544 · Cited by 209 · see citing works
Self-citation
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Moellering, R. E., Black, K. C. L., Krishnamurty, C., Baggett, B. K., Stafford, P., Rain, M., Gatenby, R. A., & Gillies, R. J. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9145-7 · Cited by 206 · see citing works
Increased pH and tumorigenicity of fibroblasts expressing a yeast proton pump
Perona, R., & Serrano, R. (1988) · Nature · doi:10.1038/334438a0 · Cited by 194 · see citing works
HDA1 and HDA3 Are Components of a Yeast Histone Deacetylase (HDA) Complex
Carmen, A. A., Rundlett, S. E., & Grunstein, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15837 · Cited by 188 · see citing works
Importance of pH regulation and lactate/H+ transport capacity for work production during supramaximal exercise in humans.
Messonnier, L., Kristensen, M., Juel, C., & Denis, C. (2007) · Journal of applied physiology · doi:10.1152/japplphysiol.00691.2006 · Cited by 164 · see citing works
Dynamics of histone acetylation in vivo. A function for acetylation turnover?
Waterborg, J. H. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-080 · Cited by 155 · see citing works
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Kim, U., Shu, C., Dane, K. Y., Daugherty, P. S., Wang, J. Y. J., & Soh, H. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708760104 · Cited by 150 · see citing works
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Wahl, M., Owen, J. A., Burd, R., Herlands, R., Nogami, S. S., Rodeck, U., Berd, D., Leeper, D. B., & Owen, C. S. (2002) · PubMed · Cited by 141 · see citing works
Protein Acetylation and Histone Deacetylase Expression Associated with Malignant Breast Cancer Progression
Suzuki, J., Chen, Y., Scott, G. K., DeVries, S., Chin, K., Benz, C. C., Waldman, F. M., & Hwang, E. S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2319 · Cited by 139 · see citing works
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Friis, R. M. N., Wu, B. P., Reinke, S. N., Hockman, D. J., Sykes, B. D., & Schultz, M. C. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp270 · Cited by 116 · see citing works
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Valli, M., Sauer, M., Branduardi, P., Borth, N., Porro, D., & Mattanovich, D. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.3.1515-1521.2005 · Cited by 103 · see citing works
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Iwabata, H., Yoshida, M., & Komatsu, Y. (2005) · PROTEOMICS · doi:10.1002/pmic.200500042 · Cited by 95 · see citing works
Chemical Genetic Modifier Screens
Koeller, K. M., Haggarty, S. J., Perkins, B. D., Leykin, I., Wong, J. C., Kao, M.-C. J., & Schreiber, S. L. (2003) · Chemistry & Biology · doi:10.1016/s1074-5521(03)00093-0 · Cited by 89 · see citing works
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Hulı́ková, A., Vaughan‐Jones, R. D., & Swietach, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.219899 · Cited by 87 · see citing works
Influence of Extracellular pH on Intracellular pH and Cell Energy Status: Relationship to Hyperthermic Sensitivity
Fellenz, M. P., & Gerweck, L. E. (1988) · Radiation Research · doi:10.2307/3577466 · Cited by 71 · see citing works
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SAMMate: a GUI tool for processing short read alignments in SAM/BAM format
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Extracellular pH and P-31 Magnetic Resonance Spectroscopic Variables are Related to Outcome in Canine Soft Tissue Sarcomas Treated with Thermoradiotherapy
Lora‐Michiels, M., Yu, D., Sanders, L. L., Poulson, J. M., Azuma, C., Case, B. C., Vujašković, Ž., Thrall, D. Ε., Charles, H. C., & Dewhirst, M. W. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2669 · Cited by 45 · see citing works
Alkalosis stimulates endothelial nitric oxide synthase in cultured human pulmonary arterial endothelial cells
Mizuno, S., Demura, Y., Ameshima, S., Okamura, S., Miyamori, I., & Ishizaki, T. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00436.2001 · Cited by 29 · see citing works
19F-NMR study of primary human T lymphocyte activation: effects of mitogen on intracellular pH
Bental, M., & DEUTSCH, C. J. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.2.c541 · Cited by 19 · see citing works
Intracellular pH Measurements In Vivo Using Green Fluorescent Protein Variants
Nehrke, K. W. (2006) · Humana Press eBooks · doi:10.1385/1-59745-151-7:223 · Cited by 18 · see citing works
Untargeted tail acetylation of histones in chromatin: lessons from yeastThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.
Friis, R. M. N., & Schultz, M. C. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-097 · Cited by 16 · see citing works
Calcium-dependent release of acetyl-coenzyme A from liver mitochondria
Benjamin, A. M., Murthy, C. R. K., & Quastel, J. H. (1983) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y83-023 · Cited by 14 · see citing works
Processing Mechanism and Substrate Selectivity of the Core NuA4 Histone Acetyltransferase Complex
Arnold, K. M., Lee, S., & Denu, J. M. (2010) · Biochemistry · doi:10.1021/bi101355a · Cited by 12 · see citing works
Role of Monocarboxylate Transport in the Regulation of Intracellular pH of Renal Proximal Tubule Cells
Boron, W. F., Siebens, A. W., & Nakhoul, N. L. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513699.ch6 · Cited by 6 · see citing works

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Biswas, S., & Rao, C. M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.011 · Cited by 243 · see citing works
Exploitation of EP300 and CREBBP Lysine Acetyltransferases by CancerPreprint
Attar, N., & Kurdistani, S. K. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026534 · Cited by 235 · see citing works
Self-citation
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Walton, Z. E., Patel, C. H., Brooks, R. C., Yu, Y., Ibrahim‐Hashim, A., Riddle, M., Porcu, A., Jiang, T., Ecker, B. L., Tameire, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.009 · Cited by 226 · see citing works
A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications
Flynn, E. M., Huang, O. W., Poy, F., Oppikofer, M., Bellon, S. F., Tang, Y., & Cochran, A. G. (2015) · Structure · doi:10.1016/j.str.2015.08.004 · Cited by 222 · see citing works
Epigenetics, cellular memory and gene regulation
Henikoff, S., & Greally, J. M. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.011 · Cited by 215 · see citing works
Undercover: gene control by metabolites and metabolic enzymesPreprint
van der Knaap, J. A., & Verrijzer, C. P. (2016) · Genes & Development · doi:10.1101/gad.289140.116 · Cited by 213 · see citing works
Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression
Kondo, A., Yamamoto, S., Nakaki, R., Shimamura, T., Hamakubo, T., Sakai, J., Kodama, T., Yoshida, T., Aburatani, H., & Osawa, T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.006 · Cited by 205 · see citing works
Nutritionally Mediated Oxidative Stress and Inflammation
Muñoz, A. B., & Costa, M. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/610950 · Cited by 205 · see citing works
The Monocarboxylate Transporter 4 Is Required for Glycolytic Reprogramming and Inflammatory Response in Macrophages
Tan, Z., Xie, N., Banerjee, S., Cui, H., Fu, M., Thannickal, V. J., & Liu, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.603589 · Cited by 186 · see citing works
Epigenetic Modifications and Head and Neck Cancer: Implications for Tumor Progression and Resistance to Therapy
CASTILHO, R. M., SQUARIZE, C. H., & Almeida, L. O. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071506 · Cited by 185 · see citing works
Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
Bradshaw, P. C. (2021) · Antioxidants · doi:10.3390/antiox10040572 · Cited by 185 · see citing works
The impact of tumour pH on cancer progression: strategies for clinical intervention
Ward, C., Meehan, J., Gray, M., Murray, A. F., Argyle, D. J., Kunkler, I. H., & Langdon, S. P. (2020) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2020.00005 · Cited by 180 · see citing works
Lessons from patient-derived xenografts for better in vitro modeling of human cancer
Choi, S. Y. C., Lin, D., Gout, P. W., Collins, C. C., Xu, Y., & Wang, Y. Z. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.09.009 · Cited by 174 · see citing works
Connections between metabolism and epigenetics in cancers
Thakur, C., & Chen, F. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.06.006 · Cited by 172 · see citing works
Neuroglial Transmission
Gundersen, V., Storm‐Mathisen, J., & Bergersen, L. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00024.2014 · Cited by 172 · see citing works
The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Corbet, C., Draoui, N., Polet, F., Pinto, A., Drozak, X., Riant, O., & Feron, O. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0705 · Cited by 169 · see citing works
Roles of pH in control of cell proliferation
Flinck, M., Kramer, S. H., & Pedersen, S. F. (2018) · Acta Physiologica · doi:10.1111/apha.13068 · Cited by 165 · see citing works
pH sensing at the intersection of tissue homeostasis and inflammation
Hajjar, S., & Zhou, X. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.08.008 · Cited by 158 · see citing works
LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2
Liao, M., Liao, W., Xu, N., Li, B., Liu, F., Zhang, S., Wang, Y., Wang, S., Zhu, Y., Chen, D., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.035 · Cited by 151 · see citing works
The rate of glycolysis quantitatively mediates specific histone acetylation sites
Cluntun, A. A., Huang, H., Dai, L., Liu, X., Zhao, Y., & Locasale, J. W. (2015) · Cancer & Metabolism · doi:10.1186/s40170-015-0135-3 · Cited by 148 · see citing works
Epigenetic modifications: Key players in cancer heterogeneity and drug resistance
Sadida, H. Q., Abdulla, A., Marzooqi, S. A., Hashem, S., Macha, M. A., Akil, A. S. A.-S., & Bhat, A. A. (2024) · Translational Oncology · doi:10.1016/j.tranon.2023.101821 · Cited by 151 · see citing works
Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism
Ye, C., & Tu, B. P. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.06.002 · Cited by 137 · see citing works
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond
Dueva, R., & Iliakis, G. E. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa022 · Cited by 130 · see citing works
The Redox Status of Cancer Cells Supports Mechanisms behind the Warburg Effect
Moreira, J. D. V., Hamraz, M., Abolhassani, M., Bigan, E., Pérès, S., Paulevé, L., Nogueira, M. L., Steyaert, J., & Schwartz, L. H. (2016) · Metabolites · doi:10.3390/metabo6040033 · Cited by 133 · see citing works
Cell fate decisions: emerging roles for metabolic signals and cell morphology
Tatapudy, S., Aloisio, F. M., Barber, D. L., & Nystul, T. G. (2017) · EMBO Reports · doi:10.15252/embr.201744816 · Cited by 123 · see citing works
Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets
Miranda‐Gonçalves, V., Lameirinhas, A., Henrique, R., & Jerónimo, C. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00427 · Cited by 122 · see citing works
An Epigenetic Role of Mitochondria in Cancer
Liu, Y., Chen, C., Wang, X., Sun, Y., Zhang, J., Chen, J., & Shi, Y. (2022) · Cells · doi:10.3390/cells11162518 · Cited by 125 · see citing works
Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca 2+ –NFAT signalingPreprint
Lee, J. V., Berry, C. T., Kim, K., Sen, P., Kim, T., Carrer, A., Trefely, S., Zhao, S., Fernandez, S., Barney, L. E., et al. (2018) · Genes & Development · doi:10.1101/gad.311027.117 · Cited by 117 · see citing works
Non-metabolic functions of glycolytic enzymes in tumorigenesis
Yu, X., & Li, S. (2016) · Oncogene · doi:10.1038/onc.2016.410 · Cited by 111 · see citing works
How protons pave the way to aggressive cancers
Swietach, P., Boedtkjer, E., & Pedersen, S. F. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00628-9 · Cited by 112 · see citing works
Metabolism and epigenetics: a link cancer cells exploit
Carrer, A., & Wellen, K. E. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.11.012 · Cited by 109 · see citing works
Acetyltransferases (HATs) as Targets for Neurological Therapeutics
Schneider‐Anthony, A., Chatterjee, S., Bousiges, O., Selvi, B. R., Swaminathan, A., Cassel, R., Blanc, F., Kundu, T. K., & Boutillier, A. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0204-7 · Cited by 108 · see citing works
An epigenetic gateway to brain tumor cell identity
Mack, S. C., Hubert, C. G., Miller, T. E., Taylor, M. D., & Rich, J. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4190 · Cited by 104 · see citing works
Epigenetics and Exercise
McGee, S. L., & Hargreaves, M. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.06.002 · Cited by 105 · see citing works
Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational Modifications
Tarazona, O. A., & Pourquié, O. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.035 · Cited by 88 · see citing works
The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target
Icard, P., & Lincet, H. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.09.003 · Cited by 85 · see citing works
An acetate switch regulates stress erythropoiesis
Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H. C., Moon, Y.-A., Gerard, R. D., Huang, C.-L., Comerford, S. A., Hammer, R. E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3587 · Cited by 87 · see citing works
Mitochondrial remodeling: Rearranging, recycling, and reprogramming
Gottlieb, R. A., & Bernstein, D. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.04.006 · Cited by 86 · see citing works
Histone acylation marks respond to metabolic perturbations and enable cellular adaptation
Jo, C., Park, S., Oh, S., Choi, J., Kim, E. K., Youn, H., & Cho, E. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00539-x · Cited by 83 · see citing works
Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation
Wang, Y., Jin, J., Chung, M. W. H., Feng, L., Sun, H., & Hao, Q. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717664115 · Cited by 82 · see citing works
Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation
Ulmschneider, B., Grillo‐Hill, B. K., Benitez, M., Azimova, D., Barber, D. L., & Nystul, T. G. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201606042 · Cited by 81 · see citing works
Cell cycle progression is regulated by intertwined redox oscillators
Moreira, J. D. V., Pérès, S., Steyaert, J., Bigan, E., Paulevé, L., Lévy, M., & Schwartz, L. H. (2015) · Theoretical Biology and Medical Modelling · doi:10.1186/s12976-015-0005-2 · Cited by 76 · see citing works
Epigenomes in Cardiovascular Disease
Rosa‐Garrido, M., Chapski, D. J., & Vondriska, T. M. (2018) · Circulation Research · doi:10.1161/circresaha.118.311597 · Cited by 71 · see citing works
Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?
Krautkramer, K. A., Rey, F. E., & Denu, J. M. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.761577 · Cited by 69 · see citing works
Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells
Díaz, F. A. E., Ochoa, V., Merlotti, A., Dantas, E., Mazzitelli, I. G., Polo, V. G., Sabatté, J., Amigorena, S., Segura, É., & Geffner, J. R. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107613 · Cited by 68 · see citing works
VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment
Hu, P., Li, T., Lin, J., Qiu, M., Wang, D., Liu, Z., Chen, Z., Yang, L.-P., Zhang, X., Zhao, Q., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00230-7 · Cited by 69 · see citing works
Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma
Pant, K., Peixoto, E., Richard, S., & Gradilone, S. A. (2020) · Cells · doi:10.3390/cells9030780 · Cited by 69 · see citing works
A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness
Kaufmann, K. B., Zeng, A. G. X., Coyaud, E., Garcia-Prat, L., Papalexi, E., Murison, A., Laurent, E. M. N., Chan-Seng-Yue, M., Gan, O. I., Pan, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00925-1 · Cited by 68 · see citing works
Fatty Acid Labeling from Glutamine in Hypoxia Can Be Explained by Isotope Exchange without Net Reductive Isocitrate Dehydrogenase (IDH) Flux
Fan, J., Kamphorst, J. J., Rabinowitz, J. D., & Shlomi, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.502740 · Cited by 67 · see citing works
Alternating pH landscapes shape epithelial cancer initiation and progression: Focus on pancreatic cancer
Pedersen, S. F., Novak, I., Alves, F., Schwab, A., & Pardo, L. A. (2017) · BioEssays · doi:10.1002/bies.201600253 · Cited by 67 · see citing works
Intratumor heterogeneity in epigenetic patterns
Assenov, Y., Brocks, D., & Gerhäuser, C. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.01.010 · Cited by 65 · see citing works
Acetylation Regulates Survival of Salmonella enterica Serovar Typhimurium under Acid Stress
Ren, J., Sang, Y., Ni, J., Jing, T., Lu, J. L., Zhao, M., & Yao, Y. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.01009-15 · Cited by 64 · see citing works
Metabolic Dysregulations and Epigenetics: A Bidirectional Interplay that Drives Tumor Progression
Crispo, F., Condelli, V., Lepore, S., Notarangelo, T., Sgambato, A., Esposito, F., Maddalena, F., & Landriscina, M. (2019) · Cells · doi:10.3390/cells8080798 · Cited by 61 · see citing works
CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4
Wang, L., Zhou, H., Wang, Y., Cui, G., & Di, L.-J. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.587 · Cited by 62 · see citing works
Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer
Yu, X., Ma, R., Wu, Y., Zhai, Y., & Li, S. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00394 · Cited by 61 · see citing works
Regulating Chromatin by Histone Acetylation
Steunou, A., Rossetto, D., & Côté, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8624-4_4 · Cited by 54 · see citing works
Metabolic interactions with cancer epigenetics
Gao, X., Reid, M. A., Kong, M., & Locasale, J. W. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.09.001 · Cited by 54 · see citing works
Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors
Shen, F., Boccuto, L., Pauly, R., Srikanth, S., & Chandrasekaran, S. (2019) · Genome biology · doi:10.1186/s13059-019-1661-z · Cited by 52 · see citing works
pH gradient reversal fuels cancer progression
Zheng, T., Jäättelä, M., & Liu, B. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105796 · Cited by 55 · see citing works
Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications
Desaulniers, D. M., Vasseur, P., Jacobs, A. C., Aguila, M. C., Ertych, N., & Jacobs, M. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010969 · Cited by 54 · see citing works
Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2
Osawa, T., Shimamura, T., Saito, K., Hasegawa, Y., Ishii, N., Nishida, M., Ando, R., Kondo, A., Anwar, M., Tsuchida, R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.087 · Cited by 53 · see citing works
O-GlcNAcylation: key regulator of glycolytic pathways
Bacigalupa, Z. A., Bhadiadra, C., & Reginato, M. J. (2018) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-018-9742-3 · Cited by 52 · see citing works
Reconstructing the intracellular pH microenvironment for enhancing photodynamic therapy
Wang, C., Zhao, P., Yang, G., Chen, X., Jiang, Y., Jiang, X., Wu, Y., Liu, Y., Zhang, W., & Bu, W. (2020) · Materials Horizons · doi:10.1039/c9mh01824g · Cited by 51 · see citing works
The SESAME complex regulates cell senescence through the generation of acetyl-CoA
Chen, W., Yu, X., Wu, Y., Tang, J., Yu, Q., Lv, X., Zha, Z., Hu, B., Li, X., Chen, J., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00412-9 · Cited by 50 · see citing works
A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy
Wilson, L. T., Tipping, W. J., Jamieson, L. E., Wetherill, C., Henley, Z. A., Faulds, K., Graham, D., Mackay, S. P., & Tomkinson, N. C. O. (2020) · The Analyst · doi:10.1039/d0an00865f · Cited by 50 · see citing works
Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation
Karner, C. M., Esen, E., Chen, J., Hsu, F., TURK, J. W., & Long, F. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.708578 · Cited by 49 · see citing works
Tracing the Origin of Cell-Free DNA Molecules through Tissue-Specific Epigenetic Signatures
Oberhofer, A., Bronkhorst, A. J., Uhlig, C., Ungerer, V., & Holdenrieder, S. (2022) · Diagnostics · doi:10.3390/diagnostics12081834 · Cited by 45 · see citing works
A two-way relationship between histone acetylation and metabolism
Charidemou, E., & Kirmizis, A. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.10.005 · Cited by 47 · see citing works
Regulation of inflammatory responses by pH-dependent transcriptional condensates
Wu, Z., Pope, S. D., Ahmed, N. S., Leung, D. L., Hong, Y., Hajjar, S., Krabak, C., Zhong, Z., Raghunathan, K., Yue, Q., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.033 · Cited by 46 · see citing works
Physical forces modulate cell differentiation and proliferation processes
Schwartz, L. H., Moreira, J. D. V., & Jolicœur, M. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13417 · Cited by 46 · see citing works
Rewiring AMPK and Mitochondrial Retrograde Signaling for Metabolic Control of Aging and Histone Acetylation in Respiratory-Defective Cells
Friis, R. M. N., Glaves, J. P., Huan, T., Li, L., Sykes, B. D., & Schultz, M. C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.029 · Cited by 44 · see citing works
A prevalent neglect of environmental control in mammalian cell culture calls for best practices
Klein, S. G., Alsolami, S. M., Steckbauer, A., Arossa, S., Parry, A. J., Ramos‐Mandujano, G., Alsayegh, K. N., Belmonte, J. C. I., Li, M., & Duarte, C. M. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00775-0 · Cited by 44 · see citing works

pH regulation by histone acetylation
Flintoft, L. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3403
Global Histone Acetylation Is Linked to pH
(2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2012-224 · Cited by 1 · see citing works
Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology
Kurdistani, S. K. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.06.002 · Cited by 36 · see citing works
Self-citation
Intracellular pH Regulation
Putnam, R. W. (2001) · Elsevier eBooks · doi:10.1016/b978-0-08-057455-4.50035-9 · Cited by 8 · see citing works
The role of intracellular pH and calcium in the regulation of cellular functions.
Martı́nez–Zaguilán, R. (1992) · UA Campus Repository (The University of Arizona)

Authors: McBrian, M. A., Behbahan, I. S., Ferrari, R., Su, T., Huang, T.-W., Li, K., Hong, C. S., Christofk, H. R., Vogelauer, M., Seligson, D. B., & Kurdistani, S. K.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Kurdistani, Siavash K.
ORCID: Ferrari, Roberto
Christofk, Heather R.
Vogelauer, Maria
Kurdistani, Siavash K.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2013-01
Volume: 49
Issue: 2
Pages: 310-321
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2012.10.025
PMC: PMC3893119
OpenAlex: W1984600164
Cited by: 272
References: 53
Citations by year: 2026: 9 · 2025: 19 · 2024: 29 · 2023: 13 · 2022: 20 · 2021: 17 · 2020: 29 · 2019: 22 · 2018: 24 · 2017: 15 · 2016: 32 · 2015: 13 · 2014: 18 · 2013: 9 · 2012: 1
FWCI: 4.93
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 388 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
American Cancer Society
California Institute for Regenerative Medicine
California Institute of Regenerative Medicine
National Institutes of Health (1dp2od006516-01)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: histone acetylation, intracellular pH, histone deacetylase, monocarboxylate transporters, chromatin acetylation, pH homeostasis, histone deacetylase inhibitors, cancer cells, cell proliferation
MeSH terms: Acetates, Acetylation, Chromatin, Gene Expression Regulation, Glucose, Glutamine, HeLa Cells, Histone Deacetylases, Histones, Humans, Hydrogen-Ion Concentration, Hydroxamic Acids, Intracellular Fluid, Niacinamide, Protein Processing, Post-Translational, Sequence Analysis, RNA, Pyruvic Acid, Monocarboxylic Acid Transporters, Carbohydrate Metabolism, Histone Deacetylase Inhibitors, Transcriptome

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Histone Acetylation Regulates Intracellular pH

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