Avruch, Joseph

Yap1 acts downstream of α-catenin to control epidermal proliferation

Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell

Hippo pathway signaling and YAP/TAZHair Growth and Disorders

Cited by 1,036

Rheb Binds and Regulates the mTOR Kinase

Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., & Avruch, J. (2005) · Current Biology

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 1,005

Raf meets Ras: completing the framework of a signal transduction pathway

Avruch, J., Zhang, X.-F., & Kyriakis, J. M. (1994) · Trends in Biochemical Sciences

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 577

Kinases mst1 and mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

Geng, J., Sun, X., Wang, P., Zhang, S., Wang, X., Wu, H., Hong, L., Xie, C., Li, X., Zhao, H., et al. (2015) · Nature Immunology

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmune Response and Inflammation

Cited by 264

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

Fitamant, J., Kottakis, F., Benhamouche, S., Tian, H. S., Chuvin, N., Parachoniak, C. A., Nagle, J. M., Perera, R. M., Lapouge, M., Deshpande, V., et al. (2015) · Cell Reports

Hippo pathway signaling and YAP/TAZLiver physiology and pathology

Cited by 248

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

Dai, N., Rapley, J., Angel, M., Yanik, M. F., Blower, M. D., & Avruch, J. (2011) · Genes & Development

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 208

IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins

Dai, N., Zhao, L., Wrighting, D., Krämer, D., Majithia, A., Wang, Y., Cracan, V., Borges-Rivera, D., Mootha, V. K., Nahrendorf, M., et al. (2015) · Cell Metabolism

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 188

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1

Dai, N., Ji, F., Wright, J., Minichiello, L., Sadreyev, R., & Avruch, J. (2017) · eLife

Growth Hormone and Insulin-like Growth FactorsRNA Research and Splicing

Cited by 103

RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression

Regué, L., Zhao, L., Ji, F., Wang, H., Avruch, J., & Dai, N. (2021) · Molecular Metabolism

Pancreatic function and diabetesRNA modifications and cancer

Cited by 60

Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage

Regué, L., Wang, W., Ji, F., Avruch, J., Wang, H., & Dai, N. (2023) · Diabetes

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 12