Pennacchio, Len A.

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics

Liver Disease Diagnosis and TreatmentGenetic Associations and Epidemiology

Cited by 3,416

ChIP-seq accurately predicts tissue-specific activity of enhancers

Visel, A., Blow, M. J., Li, Z., Zhang, T., Akiyama, J. A., Holt, A., Plajzer-Frick, I., Shoukry, M., Wright, C., Chen, F., et al. (2009) · Nature

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 1,639

A Common Allele on Chromosome 9 Associated with Coronary Heart Disease

McPherson, R., Pertsemlidis, A., Kavaslar, N., Stewart, A., Roberts, R., Cox, D. R., Hinds, D. A., Pennacchio, L. A., Tybjaerg-Hansen, A., Folsom, A. R., et al. (2007) · Science

Genetic Associations and EpidemiologyCardiovascular Health and Risk Factors

Cited by 1,587

Metagenomic discovery of biomass-degrading genes and genomes from cow rumen

Hess, M., Sczyrba, A., Egan, R., Kim, T.-W., Chokhawala, H., Schroth, G., Luo, S., Clark, D. S., Chen, F., Zhang, T., et al. (2011) · Science

Biofuel production and bioconversionAnaerobic Digestion and Biogas Production

Cited by 1,319

Guidelines for investigating causality of sequence variants in human disease

MacArthur, D. G., Manolio, T. A., Dimmock, D. P., Rehm, H. L., Shendure, J., Abecasis, G. R., Adams, D. R., Altman, R. B., Antonarakis, S. E., Ashley, E. A., et al. (2014) · Nature

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 1,224

In vivo enhancer analysis of human conserved non-coding sequences

Pennacchio, L. A., Ahituv, N., Moses, A. M., Prabhakar, S., Nobrega, M. A., Shoukry, M., Minovitsky, S., Dubchak, I., Holt, A., Lewis, K. D., et al. (2006) · Nature

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 1,165

VISTA Enhancer Browser—a database of tissue-specific human enhancers

Visel, A., Minovitsky, S., Dubchak, I., & Pennacchio, L. A. (2007) · Nucleic Acids Research

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 1,080

An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing

Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J.-C., Krauss, R. M., & Rubin, E. M. (2001) · Science

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 921

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

Parker, S. C. J., Stitzel, M. L., Taylor, D. L., Orozco, J. M., Erdos, M. R., Akiyama, J. A., van Bueren, K. L., Chines, P. S., Narisu, N., Program, N. C. S., et al. (2013) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 665

Enhancer redundancy provides phenotypic robustness in mammalian development

Osterwalder, M., Barozzi, I., Tissières, V., Fukuda-Yuzawa, Y., Mannion, B. J., Afzal, S. Y., Lee, E. A., Zhu, Y., Plajzer-Frick, I., Pickle, C. S., et al. (2018) · Nature

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 642

Genomic views of distant-acting enhancers

Visel, A., Rubin, E. M., & Pennacchio, L. A. (2009) · Nature

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 610

Most Rare Missense Alleles Are Deleterious in Humans: Implications for Complex Disease and Association Studies

Kryukov, G. V., Pennacchio, L. A., & Sunyaev, S. R. (2007) · The American Journal of Human Genetics

Evolution and Genetic DynamicsGenomics and Rare Diseases

Cited by 598

Massively parallel functional dissection of mammalian enhancers in vivo

Patwardhan, R. P., Hiatt, J. B., Witten, D. M., Kim, M. J., Smith, R. P., May, D., Lee, C., Andrie, J. M., Lee, S.-I., Cooper, G. M., et al. (2012) · Nature Biotechnology

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 536

The amphioxus genome illuminates vertebrate origins and cephalochordate biology

Holland, L. Z., Albalat, R., Azumi, K., Benito-Gutiérrez, È., Blow, M. J., Bronner-Fraser, M., Brunet, F., Butts, T., Candiani, S., Dishaw, L. J., et al. (2008) · Genome Research

Developmental Biology and Gene RegulationChromosomal and Genetic Variations

Cited by 512

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Romeo, S., Pennacchio, L. A., Fu, Y., Boerwinkle, E., Tybjaerg-Hansen, A., Hobbs, H. H., & Cohen, J. C. (2007) · Nature Genetics

Lipid metabolism and disordersGenetic Associations and Epidemiology

Cited by 511

Rapid and Pervasive Changes in Genome-wide Enhancer Usage during Mammalian Development

Nord, A. S., Blow, M. J., Attanasio, C., Akiyama, J. A., Holt, A., Hosseini, R., Phouanenavong, S., Plajzer-Frick, I., Shoukry, M., Afzal, V., et al. (2013) · Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 375

Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors

De Val, S., Chi, N. C., Meadows, S. M., Minovitsky, S., Anderson, J. P., Harris, I. S., Ehlers, M. L., Agarwal, P., Visel, A., Xu, S.-M., et al. (2008) · Cell

Developmental Biology and Gene RegulationGenomics and Chromatin Dynamics

Cited by 343

Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation

Preissl, S., Fang, R., Huang, H., Zhao, Y., Raviram, R., Gorkin, D. U., Zhang, Y., Sos, B. C., Afzal, V., Dickel, D. E., et al. (2018) · Nature Neuroscience

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 332

Germline Chd8 haploinsufficiency alters brain development in mouse

Gompers, A. L., Su-Feher, L., Ellegood, J., Copping, N. A., Riyadh, M. A., Stradleigh, T. W., Pride, M. C., Schaffler, M. D., Wade, A. A., Catta-Preta, R., et al. (2017) · Nature Neuroscience

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 266

A High-Resolution Enhancer Atlas of the Developing Telencephalon

Visel, A., Taher, L., Girgis, H., May, D., Golonzhka, O., Hoch, R. V., McKinsey, G. L., Pattabiraman, K., Silberberg, S. N., Blow, M. J., et al. (2013) · Cell

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 257

Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers

Gotea, V., Visel, A., Westlund, J. M., Nobrega, M. A., Pennacchio, L. A., & Ovcharenko, I. (2010) · Genome Research

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 248

Ultraconserved Enhancers Are Required for Normal Development

Dickel, D. E., Ypsilanti, A. R., Pla, R., Zhu, Y., Barozzi, I., Mannion, B. J., Khin, Y. S., Fukuda-Yuzawa, Y., Plajzer-Frick, I., Pickle, C. S., et al. (2018) · Cell

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 190

Dlx1&2-Dependent Expression of Zfhx1b (Sip1, Zeb2) Regulates the Fate Switch between Cortical and Striatal Interneurons

McKinsey, G. L., Lindtner, S., Trzcinski, B., Visel, A., Pennacchio, L. A., Huylebroeck, D., Higashi, Y., & Rubenstein, J. L. R. (2013) · Neuron

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 153

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility

Dogan, N., Wu, W., Morrissey, C. S., Chen, K.-B., Stonestrom, A., Long, M., Keller, C. A., Cheng, Y., Jain, D., Visel, A., et al. (2015) · Epigenetics & Chromatin

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 114