Germline Chd8 haploinsufficiency alters brain development in mouse

Basic local alignment search tool

Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669 · see citing works

Fiji: an open-source platform for biological-image analysis

Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works

Fast and accurate short read alignment with Burrows-Wheeler transform

Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works

WGCNA: an R package for weighted correlation network analysis

Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252 · see citing works

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210 · see citing works

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814 · see citing works

Gene ontology analysis for RNA-seq: accounting for selection bias

Young, M. D., Wakefield, M. J., Smyth, G. K., & Oshlack, A. (2010) · Genome Biology · doi:10.1186/gb-2010-11-2-r14 · Cited by 7,107 · see citing works

A General Framework for Weighted Gene Co-Expression Network Analysis

Zhang, B., & Horvath, S. (2005) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1128 · Cited by 5,684 · see citing works

Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain

Avants, B., Epstein, C. L., Grossman, M., & Gee, J. C. (2007) · Medical Image Analysis · doi:10.1016/j.media.2007.06.004 · Cited by 5,618 · see citing works

Thresholding of statistical maps in functional neuroimaging using the false discovery rate

Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923 · see citing works

A reproducible evaluation of ANTs similarity metric performance in brain image registration

Avants, B. B., Tustison, N. J., Song, G., Cook, P. A., Klein, A., & Gee, J. C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.025 · Cited by 4,796 · see citing works

Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space

Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431 · see citing works

RSeQC: quality control of RNA-seq experiments

Wang, L., Wang, S., & Li, W. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts356 · Cited by 2,813 · see citing works

Synaptic, transcriptional and chromatin genes disrupted in autism

Study, T. D., De Rubeis, S., Autism, H. M. C. F., UK10K Consortium, The Autism Sequencing Consortium, He, X., Goldberg, A. P., Poultney, C. S., Samocha, K., Ercument Cicek, A., et al. (2014) · Nature · doi:10.1038/nature13772 · Cited by 2,746 · see citing works

The contribution of de novo coding mutations to autism spectrum disorder

Iossifov, I., O’Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., et al. (2014) · Nature · doi:10.1038/nature13908 · Cited by 2,585 · see citing works

STRING 8--a global view on proteins and their functional interactions in 630 organisms

Jensen, L. J., Kuhn, M., Stark, M., Chaffron, S., Creevey, C. J., Muller, J., Doerks, T., Julien, P., Roth, A. C., Simonovic, M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn760 · Cited by 2,475 · see citing works

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072 · see citing works

The Reactome pathway knowledgebase

Croft, D., Mundo, A. F., Haw, R., Milacic, M., Weiser, J., Wu, G., Caudy, M., Garapati, P., Gillespie, M., Kamdar, M. R., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1102 · Cited by 1,889 · see citing works

Transcriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology

Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., Mill, J., Cantor, R. M., Blencowe, B. J., & Geschwind, D. H. (2011) · Nature · doi:10.1038/nature10110 · Cited by 1,874 · cited 1× · see citing works

Behavioural phenotyping assays for mouse models of autism

Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works

Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci

Sanders, S. J., He, X., Willsey, A. J., Ercan-Sencicek, A. G., Samocha, K. E., Cicek, A. E., Murtha, M. T., Bal, V. H., Bishop, S. L., Dong, S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.016 · Cited by 1,430 · see citing works

Analysis and design of RNA sequencing experiments for identifying isoform regulation

Katz, Y., Wang, E. T., Airoldi, E. M., & Burge, C. B. (2010) · Nature Methods · doi:10.1038/nmeth.1528 · Cited by 1,353 · see citing works

The Reactome pathway Knowledgebase

Fabregat, A., Sidiropoulos, K., Garapati, P., Gillespie, M., Hausmann, K., Haw, R., Jassal, B., Jupe, S., Korninger, F., McKay, S., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1351 · Cited by 1,201 · see citing works

Chromatin remodelling during development

Ho, L., & Crabtree, G. R. (2010) · Nature · doi:10.1038/nature08911 · Cited by 1,114 · see citing works

Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism

Parikshak, N. N., Luo, R., Zhang, A., Won, H., Lowe, J. K., Chandran, V., Horvath, S., & Geschwind, D. H. (2013) · Cell · doi:10.1016/j.cell.2013.10.031 · Cited by 1,039 · see citing works

Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism

Willsey, A. J., Sanders, S. J., Li, M., Dong, S., Tebbenkamp, A. T., Muhle, R. A., Reilly, S. K., Lin, L., Fertuzinhos, S., Miller, J. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.020 · Cited by 934 · see citing works

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development

Bernier, R., Golzio, C., Xiong, B., Stessman, H. A., Coe, B. P., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Vulto-van Silfhout, A. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.017 · Cited by 798 · see citing works

Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

Rogers, D. C., Fisher, E. M. C., Brown, S. D. M., Peters, J., Hunter, A. J., & Martin, J. E. (1997) · Mammalian Genome · doi:10.1007/s003359900551 · Cited by 795 · see citing works

Genetic studies in intellectual disability and related disorders

Vissers, L. E. L. M., Gilissen, C., & Veltman, J. A. (2016) · Nature Reviews Genetics · doi:10.1038/nrg3999 · Cited by 761 · see citing works

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

Thomas, A., Burant, A., Bui, N., Graham, D., Yuva-Paylor, L. A., & Paylor, R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1466-y · Cited by 698 · see citing works

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

Parikshak, N. N., Swarup, V., Belgard, T. G., Irimia, M., Ramaswami, G., Gandal, M. J., Hartl, C., Leppa, V., Ubieta, L. D. L. T., Huang, J., et al. (2016) · Nature · doi:10.1038/nature20612 · Cited by 685 · cited 4× · see citing works

Chromatin modifiers and remodellers: regulators of cellular differentiation

Chen, T., & Dent, S. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3607 · Cited by 613 · see citing works

Automated Three‐Chambered Social Approach Task for Mice

Yang, M., Silverman, J. L., & Crawley, J. N. (2011) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0826s56 · Cited by 598 · see citing works

Regulatory Sequence Analysis Tools

van Helden, J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg567 · Cited by 545 · see citing works

From neural development to cognition: unexpected roles for chromatin

Ronan, J. L., Wu, W., & Crabtree, G. R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3413 · Cited by 544 · see citing works

High resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl/6J mice

Dorr, A. E., Lerch, J. P., Spring, S., Kabani, N. J., & Henkelman, R. M. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.037 · Cited by 539 · see citing works

Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

Etherton, M. R., Blaiss, C. A., Powell, C. M., & Südhof, T. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910297106 · Cited by 447 · see citing works

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology

Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438 · see citing works

Rapid and Pervasive Changes in Genome-wide Enhancer Usage during Mammalian Development

Nord, A. S., Blow, M. J., Attanasio, C., Akiyama, J. A., Holt, A., Hosseini, R., Phouanenavong, S., Plajzer-Frick, I., Shoukry, M., Afzal, V., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.033 · Cited by 375 · see citing works

Isolated heart perfusion according to Langendorff—Still viable in the new millennium

Skrzypiec‐Spring, M., Grotthus, B., Szeląg, A., & Schulz, R. (2006) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2006.05.006 · Cited by 356 · see citing works

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., & Nakayama, K. I. (2016) · Nature · doi:10.1038/nature19357 · Cited by 353 · see citing works

The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment

Cotney, J., Muhle, R. A., Sanders, S. J., Liu, L., Willsey, A. J., Niu, W., Liu, W., Klei, L., Lei, J., Yin, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7404 · Cited by 350 · see citing works

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

Zhang, X., Chen, M. H., Wu, X., Kodani, A., Fan, J., Doan, R. N., Ozawa, M., Ma, J., Yoshida, N., Reiter, J. F., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.025 · Cited by 343 · see citing works

<i>CHD8</i> regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

Sugathan, A., Biagioli, M., Golzio, C., Erdin, S., Blumenthal, I., Manavalan, P., Ragavendran, A., Brand, H., Lucente, D., Miles, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405266111 · Cited by 342 · see citing works

Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters

Scattoni, M. L., Ricceri, L., & Crawley, J. N. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00623.x · Cited by 336 · see citing works

De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability

McCarthy, S. E., Gillis, J., Kramer, M., Lihm, J., Yoon, S. C., Berstein, Y., Mistry, M., Pavlidis, P., Solomon, R., Ghiban, E., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.29 · Cited by 332 · see citing works

Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice

Chadman, K. K., Gong, S., Scattoni, M. L., Boltuck, S. E., Gandhy, S. U., Heintz, N., & Crawley, J. N. (2008) · Autism Research · doi:10.1002/aur.22 · Cited by 292 · see citing works

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity

Ellegood, J., Anagnostou, E., Babineau, B. A., Crawley, J. N., Lin, L., Genestine, M., DiCicco-Bloom, E., Lai, J. K. Y., Foster, J. A., Peñagarikano, O., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.98 · Cited by 288 · see citing works

Using MACS to Identify Peaks from ChIP‐Seq Data

Feng, J., Liu, T., & Zhang, Y. (2011) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi0214s34 · Cited by 253 · see citing works

Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism

Silverman, J. L., Smith, D. G., Rizzo, S. J. S., Karras, M. N., Turner, S. M., Tolu, S. S., Bryce, D. K., Smith, D. L., Fonseca, K., Ring, R. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003501 · Cited by 251 · see citing works

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABA _B Receptors with Arbaclofen

Henderson, C., Wijetunge, L., Kinoshita, M. N., Shumway, M., Hammond, R. S., Postma, F. R., Brynczka, C., Rush, R., Thomas, A., Paylor, R., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004218 · Cited by 249 · see citing works

The discovery of integrated gene networks for autism and related disorders

Hormozdiari, F., Penn, O., Borenstein, E., & Eichler, E. E. (2015) · Genome Research · doi:10.1101/gr.178855.114 · Cited by 249 · see citing works

RSAT 2015: Regulatory Sequence Analysis Tools

Medina-Rivera, A., Defrance, M., Sand, O., Herrmann, C., Castro-Mondragon, J. A., Delerce, J., Jaeger, S., Blanchet, C., Vincens, P., Caron, C., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv362 · Cited by 246 · see citing works

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

Espuny-Camacho, I., Arranz, A. M., Fiers, M., Snellinx, A., Ando, K., Munck, S., Bonnefont, J., Lambot, L., Corthout, N., Omodho, L., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.001 · Cited by 244 · see citing works

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

Durak, O., Gao, F., Kaeser-Woo, Y. J., Rueda, R., Martorell, A. J., Nott, A., Liu, C. Y., Watson, L. A., & Tsai, L.-H. (2016) · Nature Neuroscience · doi:10.1038/nn.4400 · Cited by 243 · see citing works

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

Platt, R. J., Zhou, Y., Slaymaker, I. M., Shetty, A. S., Weisbach, N. R., Kim, J.-A., Sharma, J., Desai, M., Sood, S., Kempton, H. R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.052 · Cited by 240 · see citing works

Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes

Lee, J.-A., Damianov, A., Lin, C.-H., Fontes, M., Parikshak, N. N., Anderson, E. S., Geschwind, D. H., Black, D. L., & Martin, K. C. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.025 · Cited by 232 · see citing works

GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism

Silverman, J. L., Pride, M. C., Hayes, J. E., Puhger, K. R., Butler-Struben, H. M., Baker, S., & Crawley, J. N. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.66 · Cited by 215 · see citing works

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

Nishiyama, M., Oshikawa, K., Tsukada, Y.-I., Nakagawa, T., Iemura, S.-I., Natsume, T., Fan, Y., Kikuchi, A., Skoultchi, A. I., & Nakayama, K. I. (2009) · Nature Cell Biology · doi:10.1038/ncb1831 · Cited by 203 · see citing works

Behavioural methods used in rodent models of autism spectrum disorders: Current standards and new developments

Wöhr, M., & Scattoni, M. L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.047 · Cited by 178 · see citing works

Genetic Effects on Cerebellar Structure Across Mouse Models of Autism Using a Magnetic Resonance Imaging Atlas

Steadman, P. E., Ellegood, J., Szulc, K. U., Turnbull, D. H., Joyner, A. L., Henkelman, R. M., & Lerch, J. P. (2013) · Autism Research · doi:10.1002/aur.1344 · Cited by 169 · see citing works

Preparation of fixed mouse brains for MRI

Cahill, L. S., Laliberté, C. L., Ellegood, J., Spring, S., Gleave, J. A., van Eede, M. C., Lerch, J. P., & Henkelman, R. M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.100 · Cited by 153 · see citing works

Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism

Laumonnier, F., Shoubridge, C., Antar, C., Nguyen, L. S., Esch, H. V., Kleefstra, T., Briault, S., Fryns, J. P., Hamel, B., Chelly, J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.14 · Cited by 149 · see citing works

Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism

Silverman, J. L., Yang, M., Turner, S. M., Katz, A. M., Bell, D. B., Koenig, J. I., & Crawley, J. N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.059 · Cited by 146 · see citing works

Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests

Clipperton‐Allen, A. E., & Page, D. T. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu057 · Cited by 134 · see citing works

Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease

Lerch, J. P., Carroll, J. B., Dorr, A. E., Spring, S., Evans, A. C., Hayden, M. R., Sled, J. G., & Henkelman, R. M. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.019 · Cited by 133 · see citing works

Long-term exposure to intranasal oxytocin in a mouse autism model

Bales, K. L., Solomon, M., Jacob, S., Crawley, J. N., Silverman, J. L., Larke, R. H., Sahagún, E., Puhger, K. R., Pride, M. C., & Mendoza, S. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.117 · Cited by 131 · see citing works

Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography

Nieman, B. J., Flenniken, A. M., Adamson, S. L., Henkelman, R. M., & Sled, J. G. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00217.2005 · Cited by 122 · see citing works

Comprehensive analysis of the 16p11.2 deletion and null Cntnap2 mouse models of autism spectrum disorder

Brunner, D., Kabitzke, P., He, D., Cox, K., Thiede, L., Hanania, T., Sabath, E., Alexandrov, V., Saxe, M., Peles, E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134572 · Cited by 111 · see citing works

Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome

Thomas, A. M., Bui, N., Perkins, J. R., Yuva‐Paylor, L. A., & Paylor, R. E. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2375-4 · Cited by 99 · see citing works

Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology

Orosco, L. A., Ross, A. P., Cates, S. L., Scott, S. E., Wu, D., Sohn, J., Pleasure, D., Pleasure, S. J., Adamopoulos, I. E., & Zarbalis, K. S. (2014) · Nature Communications · doi:10.1038/ncomms5692 · Cited by 90 · see citing works

Early Embryonic Death in Mice Lacking the β-Catenin-Binding Protein Duplin

Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A., & Nakayama, K. I. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8386-8394.2004 · Cited by 86 · see citing works

FMR1 premutation and full mutation molecular mechanisms related to autism

Hagerman, R., Au, J., & Hagerman, P. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9084-5 · Cited by 85 · see citing works

First glimpses of the neurobiology of autism spectrum disorder

Sanders, S. J. (2015) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2015.10.002 · Cited by 84 · see citing works

Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity

Galazo, M. J., Emsley, J. G., & Macklis, J. D. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.024 · Cited by 80 · see citing works

Post‐transcriptional regulation in corticogenesis: how RNA‐binding proteins help build the brain

Pilaz, L., & Silver, D. L. (2015) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1289 · Cited by 71 · see citing works

16p11.2 deletion mice display cognitive deficits in touchscreen learning and novelty recognition tasks

Yang, M., Lewis, F. C., Sarvi, M. S., Foley, G. M., & Crawley, J. N. (2015) · Learning &amp; Memory · doi:10.1101/lm.039602.115 · Cited by 70 · see citing works

Distinct molecular phenotype of inflammatory breast cancer compared to non-inflammatory breast cancer using Affymetrix-based genome-wide gene-expression analysis

Laere, S. V., der Auwera, I. V., den Eynden, G. V., Hummelen, P. V., van Dam, P. A., Marck, E. V., Vermeulen, P. B., & Dirix, L. Y. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603967 · Cited by 69 · see citing works

Full UPF3B function is critical for neuronal differentiation of neural stem cells

Alrahbeni, T. M. A., Sartor, F., Anderson, J., Miedzybrodzka, Z., McCaig, C., & Müller, B. (2015) · Molecular Brain · doi:10.1186/s13041-015-0122-1 · Cited by 66 · see citing works

In VivoMagnetic Resonance Imaging and Semiautomated Image Analysis Extend the Brain Phenotype forcdf/cdfMice

Bock, N. A., Kovacevic, N., Lipina, T. V., Roder, J., Ackerman, S. L., & Henkelman, R. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5438-05.2006 · Cited by 59 · see citing works

A Novel and Multivalent Role of Pax6 in Cerebellar Development

Yeung, J., Ha, T. J., Swanson, D. J., & Goldowitz, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4385-15.2016 · Cited by 59 · see citing works

Frequent Disruption of Chromodomain Helicase DNA-Binding Protein 8 (CHD8) and Functionally Associated Chromatin Regulators in Prostate Cancer

Damaschke, N., Yang, B., Blute, M. L., Lin, C. P., Huang, W., & Jarrard, D. F. (2014) · Neoplasia · doi:10.1016/j.neo.2014.10.003 · Cited by 51 · see citing works

Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine

Flannery, B. M., Silverman, J. L., Bruun, D. A., Puhger, K. R., McCoy, M. R., Hammock, B. D., Crawley, J. N., & Lein, P. J. (2014) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2014.10.008 · Cited by 50 · see citing works

CHD8 is an independent prognostic indicator that regulates Wnt/β-catenin signaling and the cell cycle in gastric cancer

Sawada, G., Ueo, H., Matsumura, T., Uchi, R., Ishibashi, M., Mima, K., Kurashige, J., TAKAHASHI, Y., AKIYOSHI, S., Sudo, T., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2597 · Cited by 48 · see citing works

Fast spin‐echo for multiple mouse magnetic resonance phenotyping

Nieman, B. J., Bock, N. A., Bishop, J., Sled, J. G., Chen, X., & Henkelman, R. M. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20590 · Cited by 42 · see citing works

Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism

Silverman, J. L., Babineau, B. A., Oliver, C. F., Karras, M. N., & Crawley, J. N. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.042 · Cited by 42 · see citing works

The adipogenic transcriptional cofactor ZNF638 interacts with splicing regulators and influences alternative splicing

Du, C., Ma, X., Meruvu, S., Hugendubler, L., & Mueller, E. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m047555 · Cited by 36 · see citing works

Delay and trace fear conditioning in C57BL/6 and DBA/2 mice: issues of measurement and performancePreprint

Tipps, M. E., Raybuck, J. D., Buck, K. J., & Lattal, K. M. (2014) · Learning & Memory · doi:10.1101/lm.035261.114 · Cited by 34 · see citing works

Nuclear Localization of Duplin, a β-Catenin-binding Protein, Is Essential for Its Inhibitory Activity on the Wnt Signaling Pathway

Kobayashi, M., Kishida, S., Fukui, A., Michiue, T., Miyamoto, Y., Okamoto, T., Yoneda, Y., Asashima, M., & Kikuchi, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108433200 · Cited by 31 · see citing works

Loss of neural recognition molecule NB‐3 delays the normal projection and terminal branching of developing corticospinal tract axons in the mouse

Huang, Z., Yu, Y., Shimoda, Y., Watanabe, K., & Liu, Y. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22772 · Cited by 28 · see citing works

Development of MRI ‐based atlases of non‐human brains

Ullmann, J. F. P., Janke, A. L., Reutens, D. C., & WATSON, C. R. R. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23678 · Cited by 26 · see citing works

Glucose Intolerance in Aging Male IGFBP-3 Transgenic Mice: Differential Effects of Human IGFBP-3 and Its Mutant IGFBP-3 Devoid of IGF Binding Ability

Nguyen, K. H., Yao, X., Erickson, A. G., Mishra, S., & Nyomba, B. L. G. (2014) · Endocrinology · doi:10.1210/en.2014-1271 · Cited by 22 · see citing works

SPARC‐like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS

Lloyd-Burton, S. M., & Roskams, A. J. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.23029 · Cited by 22 · see citing works

Anisotropic and restricted diffusion of water in the sciatic nerve: A 2H double‐quantum‐filtered NMR study

Seo, Y., Shinar, H., Morita, Y., & Navon, G. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199909)42:3 · Cited by 19 · see citing works

Agenesis of the corpus callosum in Nogo receptor deficient mice

Yoo, S., Motari, M. G., & Schnaar, R. L. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24064 · Cited by 11 · see citing works

The ASD Living Biology: from cell proliferation to clinical phenotype

Courchesne, E., Pramparo, T., Gazestani, V. H., Lombardo, M. V., Pierce, K., & Lewis, N. E. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0056-y · Cited by 333 · see citing works

Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy

Wang, X., Wang, B., Wu, C., Wang, J., & Sun, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031819 · Cited by 274 · see citing works

Behavioral neuroscience of autism

Takumi, T., Tamada, K., Hatanaka, F., Nakai, N., & Bolton, P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.012 · Cited by 163 · see citing works

Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis

Yu, M., Ma, L., Yuan, Y., Ye, X., Montagne, A., He, J., Ho, T., Wu, Y., Zhao, Z., Maria, N. S. S., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.037 · Cited by 160 · see citing works

Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice

Jung, H., Park, H., Choi, Y., Kang, H., Lee, E., Kweon, H., Roh, J. D., Ellegood, J., Choi, W., Kang, J., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0208-z · Cited by 157 · see citing works

Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair

Zhao, C., Dong, C., Frah, M., Deng, Y., Marie, C., Zhang, F., Xu, L., Ma, Z., Dong, X., Lin, Y., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.05.022 · Cited by 146 · see citing works

Cerebral organoid and mouse models reveal a RAB39b–PI3K–mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypesPreprint

Zhang, W., Ma, L., Yang, M., Shao, Q., Xu, J., Lu, Z., Zhao, Z., Chen, R., Chai, Y., & Chen, J. (2020) · Genes & Development · doi:10.1101/gad.332494.119 · Cited by 142 · see citing works

Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in Chd8 Haploinsufficient Mice

Suetterlin, P., Hurley, S., Mohan, C., Riegman, K. L. H., Pagani, M., Caruso, A., Ellegood, J., Galbusera, A., Crespo‐Enríquez, I., Michetti, C., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy058 · Cited by 128 · see citing works

Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

Silverman, J. L., Thurm, A. E., Ethridge, S. B., Soller, M. M., Petkova, S. P., Abel, T. G., Bauman, M. D., Brodkin, E. S., Harony‐Nicolas, H., Wöhr, M., et al. (2022) · Genes Brain & Behavior · doi:10.1111/gbb.12803 · Cited by 127 · see citing works

Rigor and reproducibility in rodent behavioral research

Gulinello, M. E., Mitchell, H. A., Chang, Q., O’Brien, W. T., Zhou, Z., Abel, T. G., Wang, L., Corbin, J. G., Veeraragavan, S., Samaco, R. C., et al. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.01.001 · Cited by 116 · see citing works

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

Lam, M., Hill, W. D., Trampush, J. W., Yu, J., Knowles, E., Davies, G., Stahl, E. A., Huckins, L. M., Liewald, D. C. M., Djurovic, S., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.012 · Cited by 113 · see citing works

The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective

Mossink, B., Negwer, M., Schubert, D., & Nadif Kasri, N. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03714-5 · Cited by 114 · see citing works

Whole-brain comparison of rodent and human brains using spatial transcriptomics

Beauchamp, A., Yee, Y., Darwin, B. C., Raznahan, A., Mars, R. B., & Lerch, J. P. (2022) · eLife · doi:10.7554/elife.79418 · Cited by 111 · see citing works

A perturbed gene network containing PI3K–AKT, RAS–ERK and WNT–β-catenin pathways in leukocytes is linked to ASD genetics and symptom severity

Gazestani, V., Pramparo, T., Nalabolu, S. R., Kellman, B. P., Murray, S. S., Lopez, L., Pierce, K., Courchesne, E., & Lewis, N. E. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0489-x · Cited by 109 · see citing works

Prenatal environmental stressors impair postnatal microglia function and adult behavior in males

Block, C. L., Eroglu, O., Mague, S. D., Smith, C. J. W., Ceasrine, A. M., Sriworarat, C., Blount, C., Beben, K. A., Malacon, K. E., Ndubuizu, N., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111161 · Cited by 102 · see citing works

Dysfunction of the corticostriatal pathway in autism spectrum disorders

Li, W., & Pozzo‐Miller, L. D. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24560 · Cited by 106 · see citing works

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

Matsumura, K., Seiriki, K., Okada, S., Nagase, M., Ayabe, S., Yamada, I., Furuse, T., Shibuya, H., Yasuda, Y., Yamamori, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14697-z · Cited by 106 · see citing works

Developmental social communication deficits in the Shank3 rat model of phelan‐mcdermid syndrome and autism spectrum disorder

Berg, E. L., Copping, N. A., Rivera, J. K., Pride, M. C., Careaga, M., Bauman, M. D., Berman, R. F., Lein, P. J., Harony‐Nicolas, H., Buxbaum, J. D., et al. (2018) · Autism Research · doi:10.1002/aur.1925 · Cited by 93 · see citing works

CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories

Villa, C. E., Cheroni, C., Dotter, C. P., López-Tóbon, A., Oliveira, B., Sacco, R., Yahya, A. Ç., Morandell, J., Gabriele, M., Tavakoli, M. R., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110615 · Cited by 92 · see citing works

Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons

Xu, Q., Liu, Y.-Y., Wang, X., Tan, G., Li, H., Hulbert, S. W., Li, C., Hu, C.-C., Xiong, Z., Xu, X., et al. (2018) · Molecular Autism · doi:10.1186/s13229-018-0244-2 · Cited by 89 · see citing works

Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8+/− mouse model of ASD-like behavior

Yu, Y., Zhang, B., Ji, P., Zuo, Z., Huang, Y., Wang, N., Liu, C., Liu, S., & Zhao, F. (2022) · Nature Communications · doi:10.1038/s41467-022-28746-2 · Cited by 89 · see citing works

Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome

Copping, N. A., Christian, S., Ritter, D., Islam, M. S., Buscher, N., Żółkowska, D., Pride, M. C., Berg, E. L., LaSalle, J. M., Ellegood, J., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx289 · Cited by 88 · see citing works

A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes

Cederquist, G., Tchieu, J. H., Callahan, S. J., Ramnarine, K., Ryan, S. D., Zhang, C., Rittenhouse, C. A., Zeltner, N., Chung, S. Y., Zhou, T., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.06.004 · Cited by 85 · see citing works

Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory

Kim, Y. J., Khoshkhoo, S., Frankowski, J. C., Zhu, B., Abbasi, S., Lee, S., Wu, Y. E., & Hunt, R. F. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.049 · Cited by 76 · see citing works

Invited Review: Epigenetics in neurodevelopment

Salinas, R. D., Connolly, D. R., & Song, H. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12608 · Cited by 81 · see citing works

Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

Zhu, L., 昆明650500，中国, 云., Zhu, Y., Gu, L., & Cheng, Y. (2021) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2021.251 · Cited by 84 · see citing works

NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients

Bertacchi, M., Romano, A. L., Loubat, A., Mau‐Them, F. T., Willems, M., Faivre, L. O., Kien, P. K. V., Perrin, L., Devillard, F., Sorlin, A., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019104163 · Cited by 74 · see citing works

DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders

Christian, D. L., Wu, D. Y., Martin, J. R., Moore, J. R., Liu, Y. R., Clemens, A. W., Nettles, S. A., Kirkland, N. M., Papouin, T., Hill, C. A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108416 · Cited by 78 · see citing works

Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice

Shibutani, M., Horii, T., Shoji, H., Morita, S., Kimura, M., Terawaki, N., Miyakawa, T., & Hatada, I. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091872 · Cited by 72 · see citing works

Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome

Adhikari, A., Copping, N. A., Onaga, B., Pride, M. C., Coulson, R. L., Yang, M., Yasui, D. H., LaSalle, J. M., & Silverman, J. L. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.05.011 · Cited by 76 · see citing works

Deficient or Excess Folic Acid Supply During Pregnancy Alter Cortical Neurodevelopment in Mouse Offspring

Crescenzo, A. H. D., Panoutsopoulos, A. A., Tat, L., Schaaf, Z. A., Racherla, S., Henderson, L., Leung, K., Greene, N. D. E., Green, R., & Zarbalis, K. S. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa248 · Cited by 73 · see citing works

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes

Markenscoff-Papadimitriou, E., Binyameen, F., Whalen, S., Price, J., Lim, K. J., Ypsilanti, A. R., Catta-Preta, R., Pai, E. L.-L., Mu, X. N., Xu, D., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110089 · Cited by 72 · see citing works

Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish

Dougnon, G., & Matsui, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147550 · Cited by 71 · see citing works

The Mechanisms of CHD8 in Neurodevelopment and Autism Spectrum Disorders

Weissberg, O., & Elliott, E. (2021) · Genes · doi:10.3390/genes12081133 · Cited by 68 · see citing works

Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and diseasePreprint

Alendar, A., & Berns, A. J. M. (2021) · Genes & Development · doi:10.1101/gad.348897.121 · Cited by 65 · see citing works

A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation

Chen, J., Lambo, M. E., Ge, X., Dearborn, J. T., Liu, Y., McCullough, K. B., Swift, R. G., Tabachnick, D. R., Tian, L., Noguchi, K., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.009 · Cited by 61 · see citing works

Volumes of brain structures in captive wild-type and laboratory rats: 7T magnetic resonance in vivo automatic atlas-based study

Welniak–Kaminska, M., Fiedorowicz, M., Orzel, J., Bogorodzki, P., Modlinska, K., Stryjek, R., Chrzanowska, A., Pisula, W., & Grieb, P. (2019) · PLOS ONE · doi:10.1371/journal.pone.0215348 · Cited by 61 · see citing works

What we can learn from a genetic rodent model about autism

Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 59 · see citing works

Observational fear behavior in rodents as a model for empathy

Kim, A., Keum, S., & Shin, H. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12521 · Cited by 60 · see citing works

Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

Berg, E. L., Pride, M. C., Petkova, S. P., Lee, R. D., Copping, N. A., Shen, Y., Adhikari, A., Fenton, T. A., Pedersen, L. R., Noakes, L. S., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0720-2 · Cited by 58 · see citing works

ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis

Sokpor, G., Castro-Hernández, R., Rosenbusch, J., Staiger, J. F., & Tuoc, T. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00226 · Cited by 60 · see citing works

Regulation of neuronal connectivity in the mammalian brain by chromatin remodeling

Goodman, J. V., & Bonni, A. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.04.010 · Cited by 60 · see citing works

Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice

Kawamura, A., Katayama, Y., Nishiyama, M., Shoji, H., Tokuoka, K., Ueta, Y., Miyata, M., Isa, T., Miyakawa, T., Hayashi‐Takagi, A., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa036 · Cited by 56 · see citing works

Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration

Jiang, D., Li, T., Guo, C., Tang, T.-S., & Liu, H. (2023) · Cell &amp; Bioscience · doi:10.1186/s13578-023-00953-4 · Cited by 54 · see citing works

Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice

Ellingford, R. A., Panasiuk, M. J., de Meritens, E. R., Shaunak, R., Naybour, L., Browne, L., Basson, M. A., & Andreae, L. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01070-9 · Cited by 50 · see citing works

HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development

Tang, T., Zhang, Y., Wang, Y., Cai, Z., Lu, Z., Li, L., Huang, R., Hagelkrüys, A., Matthias, P., Zhang, H., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.007 · Cited by 53 · see citing works

Genetic mechanisms of regression in autism spectrum disorder

Tammimies, K. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.022 · Cited by 53 · see citing works

Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm

Junior, H. P. D. O. S., Bhattacharya, A., Joseph, R. M., Smeester, L., Kuban, K., Marsit, C. J., O’Shea, T. M., & Fry, R. C. (2020) · Molecular Autism · doi:10.1186/s13229-020-00402-w · Cited by 50 · see citing works

The clinical presentation caused by truncating <i>CHD8</i> variants

Douzgou, S., Liang, H. W., Metcalfe, K., Somarathi, S., Tischkowitz, M., Mohamed, W., Kini, U., McKee, S., Yates, L., Bertoli, M., et al. (2019) · Clinical Genetics · doi:10.1111/cge.13554 · Cited by 52 · see citing works

The autism-associated protein CHD8 is required for cerebellar development and motor function

Kawamura, A., Katayama, Y., Kakegawa, W., Ino, D., Nishiyama, M., Yuzaki, M., & Nakayama, K. I. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108932 · Cited by 50 · see citing works

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

Amar, M., Pramod, A. B., Yu, N., Herrera, V. M., Qiu, L. R., Losada, P. M., Zhang, P., Trujillo, C. A., Ellegood, J., Urresti, J., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01052-x · Cited by 50 · see citing works

Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells

Adhikari, A., Copping, N. A., Beegle, J. R., Cameron, D. L., Deng, P., O’Geen, H., Segal, D. J., Fink, K. D., Silverman, J. L., & Anderson, J. S. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab104 · Cited by 49 · see citing works

Mechanisms Underlying Circuit Dysfunction in Neurodevelopmental Disorders

Exposito-Alonso, D., & Rico, B. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072820-023642 · Cited by 49 · see citing works

Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model

O’Geen, H., Beitnere, U., Garcia, M. S., Adhikari, A., Cameron, D. L., Fenton, T. A., Copping, N. A., Deng, P., Lock, S., Halmai, J. A. N. M., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.01.013 · Cited by 50 · see citing works

Neuronal and glial cell number is altered in a cortical layer-specific manner in autism

Falcone, C., Mevises, N.-Y., Hong, T., Dufour, B. D., Chen, X., Noctor, S. C., & Martínez‐Cerdeño, V. (2021) · Autism · doi:10.1177/13623613211014408 · Cited by 47 · see citing works

Neural Transcriptomic Analysis of Sex Differences in Autism Spectrum Disorder: Current Insights and Future Directions

Kissel, L. T., & Werling, D. M. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.11.023 · Cited by 46 · see citing works

Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency

Tabbaa, M., Knoll, A., & Levitt, P. (2023) · Neuron · doi:10.1016/j.neuron.2023.01.009 · Cited by 45 · see citing works

Regulatory genes and pathways disrupted in autism spectrum disorders

Ayhan, F., & Konopka, G. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.017 · Cited by 44 · see citing works

Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice

Moore, S. M., Seidman, J. S., Ellegood, J., Gao, R., Savchenko, A., Troutman, T. D., Abe, Y., Stender, J. D., Lee, D., Wang, S., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-018-0344-y · Cited by 45 · see citing works

MRI to Assess Neurological Function

Nieman, B. J., van Eede, M. C., Spring, S., Dazai, J., Henkelman, R. M., & Lerch, J. P. (2018) · Current Protocols in Mouse Biology · doi:10.1002/cpmo.44 · Cited by 44 · see citing works

Genetic backgrounds have unique seizure response profiles and behavioral outcomes following convulsant administration

Copping, N. A., Adhikari, A., Petkova, S. P., & Silverman, J. L. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.106547 · Cited by 40 · see citing works

Translational outcomes relevant to neurodevelopmental disorders following early life exposure of rats to chlorpyrifos

Berg, E. L., Ching, T. M., Bruun, D. A., Rivera, J. K., Careaga, M., Ellegood, J., Lerch, J. P., Wöhr, M., Lein, P. J., & Silverman, J. L. (2020) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09342-1 · Cited by 43 · see citing works

Parallel functional testing identifies enhancers active in early postnatal mouse brain

Lambert, J. T., Su-Feher, L., Cichewicz, K., Warren, T. L., Zdilar, I., Wang, Y., Lim, K. J., Haigh, J., Morse, S. J., Canales, C. P., et al. (2021) · eLife · doi:10.7554/elife.69479 · Cited by 39 · see citing works

CHD8 dosage regulates transcription in pluripotency and early murine neural differentiation

Sood, S., Weber, C. M., Hodges, H. C., Krokhotin, A., Shalizi, A., & Crabtree, G. R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921963117 · Cited by 42 · see citing works

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

Hurley, S., Mohan, C., Suetterlin, P., Ellingford, R. A., Riegman, K. L. H., Ellegood, J., Caruso, A., Michetti, C., Brock, O., Evans, R., et al. (2021) · Molecular Autism · doi:10.1186/s13229-020-00409-3 · Cited by 42 · see citing works

Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency

Wade, A. A., Lim, K. J., Catta-Preta, R., & Nord, A. S. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00481 · Cited by 38 · see citing works

Chromatin Remodeler CHD8 in Autism and Brain Development

Hoffmann, A., & Spengler, D. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10020366 · Cited by 41 · see citing works

Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome

Copping, N. A., & Silverman, J. L. (2021) · Molecular Autism · doi:10.1186/s13229-021-00416-y · Cited by 39 · see citing works

Sequential perturbations to mouse corticogenesis following in utero maternal immune activation

Canales, C. P., Estes, M. L., Cichewicz, K., Angara, K., Aboubechara, J. P., Cameron, S., Prendergast, K., Su-Feher, L., Zdilar, I., Kreun, E. J., et al. (2021) · eLife · doi:10.7554/elife.60100 · Cited by 38 · see citing works

Mapping the landscape of social behavior

Klibaite, U., Li, T., Aldarondo, D. E., Akoad, J. F., Ölveczky, B. P., & Dunn, T. (2025) · Cell · doi:10.1016/j.cell.2025.01.044 · Cited by 39 · see citing works

Behavioral and neuroanatomical approaches in models of neurodevelopmental disorders: opportunities for translation

Silverman, J. L., & Ellegood, J. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000537 · Cited by 35 · see citing works

Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors

Kweon, H., Jung, W. B., Im, G. H., Ryoo, J., Lee, J.-H., Do, H., Choi, Y., Song, Y.-H., Jung, H., Park, H., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108780 · Cited by 36 · see citing works

Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

Jiménez, J. A., Ptacek, T., Tuttle, A. H., Schmid, R. S., Moy, S. S., Simon, J. M., & Zylka, M. J. (2020) · Molecular Autism · doi:10.1186/s13229-020-00369-8 · Cited by 36 · see citing works

Clinical Phenotypes of Carriers of Mutations in CHD8 or Its Conserved Target Genes

Beighley, J. S., Hudac, C. M., Arnett, A. B., Peterson, J. L., Gerdts, J. A., Wallace, A. S., Mefford, H. C., Hoekzema, K., Turner, T. N., O’Roak, B. J., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.020 · Cited by 33 · see citing works

Molecular causes of sex‐specific deficits in rodent models of neurodevelopmental disorders

Mossa, A., & Manzini, M. C. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24577 · Cited by 36 · see citing works

Rare and de novo coding variants in chromodomain genes in Chiari I malformation

Sadler, B. E., Wilborn, J., Antunes, L., Kuensting, T., Hale, A. T., Gannon, S. R., McCall, K., Cruchaga, C., Harms, M. B., Voisin, N., et al. (2020) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2020.12.001 · Cited by 35 · see citing works

Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction

Shi, X., Lu, C., Corman, A., Nikish, A., Zhou, Y., Platt, R. J., Iossifov, I. H., Zhang, F., Pan, J. Q., & Sanjana, N. E. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.09.004 · Cited by 34 · see citing works

Twenty years of discoveries emerging from mouse models of autism

Crawley, J. N. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105053 · Cited by 32 · see citing works

Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats

Berg, E. L., Pedersen, L. R., Pride, M. C., Petkova, S. P., Patten, K. T., Valenzuela, A. E., Wallis, C., Bein, K. J., Wexler, A. S., Lein, P. J., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00978-0 · Cited by 33 · see citing works

Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development

Ellegood, J., Petkova, S. P., Kinman, A. I., Qiu, L. R., Adhikari, A., Wade, A. A., Fernandes, D., Lindenmaier, Z., Creighton, A., Nutter, L. M. J., et al. (2021) · Molecular Autism · doi:10.1186/s13229-021-00432-y · Cited by 33 · see citing works

Convergence of spectrums: neuronal gene network states in autism spectrum disorder

Sullivan, J. M., Rubeis, S. D., & Schaefer, A. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.04.011 · Cited by 30 · see citing works

Linking Autism Risk Genes to Disruption of Cortical Development

García-Forn, M., Boitnott, A., Akpinar, Z., & Rubeis, S. D. (2020) · Cells · doi:10.3390/cells9112500 · Cited by 32 · see citing works

MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention

Weigel, B., Tegethoff, J. F., Grieder, S. D., Lim, B., Nagarajan, B., Liu, Y.-C., Truberg, J., Papageorgiou, D., Adrian-Segarra, J. M., Schmidt, L. K., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01959-7 · Cited by 31 · see citing works

Molecular mechanisms for targeted ASD treatments

Basilico, B., Morandell, J., & Novarino, G. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.06.004 · Cited by 30 · see citing works

PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice, and Fruit Flies

Al-Amri, A. H., Armstrong, P., Amici, M., Ligneul, C., Rouse, J. L., El‐Asrag, M. E., Pantiru, A., Vancollie, V. E., Ng, H. W. Y., Ogbeta, J. A., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.12.017 · Cited by 29 · see citing works

Epigenetic cues modulating the generation of cell‐type diversity in the cerebral cortex

Amberg, N., Laukoter, S., & Hippenmeyer, S. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14601 · Cited by 28 · see citing works

Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish

Pensado‐López, A., Veiga-Rúa, S., Carracedo, Á., Allegue, C., & Sanchez, L. E. (2020) · Genes · doi:10.3390/genes11111376 · Cited by 31 · see citing works

Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches

Hui, K. K., Katayama, Y., Nakayama, K. I., Nomura, J., & Sakurai, T. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.001 · Cited by 30 · see citing works

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

Li, B., Zhao, H., Tu, Z., Yang, W., Han, R., Wang, L., Luo, X., Pan, M., Chen, X., Zhang, J., et al. (2023) · Cell Discovery · doi:10.1038/s41421-023-00525-3 · Cited by 30 · see citing works

Epigenetic and Cellular Diversity in the Brain through Allele-Specific Effects

Huang, W.-C., Bennett, K., & Gregg, C. J. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.07.005 · Cited by 27 · see citing works

CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing

Kerschbamer, E., Arnoldi, M., Tripathi, T., Pellegrini, M., Maturi, S., Erdin, S., Salviato, E., Leva, F. D., Sebestyén, E., Dassi, E., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac1134 · Cited by 27 · see citing works

Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

Genç, Ö., An, J., Fetter, R. D., Kulik, Y. D., Zunino, G., Sanders, S., & Davis, G. W. (2020) · eLife · doi:10.7554/elife.55775 · Cited by 26 · see citing works

Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency

Dugger, S. A., Dhindsa, R. S., Sampaio, G. L. D. A., Ressler, A. K., Rafikian, E. E., Petri, S., Letts, V. A., Teoh, J. J., Ye, J., Colombo, S., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010952 · Cited by 29 · see citing works

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes

Megagiannis, P., Yuan, M., Yan, R., Yuan, L., Wilde, J. J., Eckersberg, H., Suresh, R., Tan, X., Chen, H., Farmer, W. T., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114637 · Cited by 25 · see citing works

Single-cell delineation of the microbiota-gut-brain axis: Probiotic intervention in Chd8 haploinsufficient mice

Ji, P., Wang, N., Yu, Y., Zhu, J., Zuo, Z., Zhang, B., & Zhao, F. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100768 · Cited by 28 · see citing works

Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism

Михайлович, Ч. С., Gerasimenko, M., Yuhi, T., Furuhara, K., Tsuji, C., Yokoyama, S., Nakayama, K. I., Nishiyama, M., & Higashida, H. (2021) · BMC Neuroscience · doi:10.1186/s12868-021-00631-6 · Cited by 24 · see citing works

Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice

Haigh, J., Adhikari, A., Copping, N. A., Stradleigh, T. W., Wade, A. A., Catta-Preta, R., Su-Feher, L., Zdilar, I., Morse, S. J., Fenton, T. A., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00884-0 · Cited by 24 · see citing works

Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors

Li, Y., Fan, T., Li, X., Liu, L., Mao, F., Li, Y., Miao, Z., Zeng, C., Song, W., Pan, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111289 · Cited by 25 · see citing works

Autism‐linked CHD gene expression patterns during development predict multi‐organ disease phenotypes

Kasah, S., Oddy, C., & Basson, M. A. (2018) · Journal of Anatomy · doi:10.1111/joa.12889 · Cited by 25 · see citing works

The potential association of psychoactive pharmaceuticals in the environment with human neurological disorders

Kaushik, G., & Thomas, M. A. (2019) · Sustainable Chemistry and Pharmacy · doi:10.1016/j.scp.2019.100148 · Cited by 24 · see citing works

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., & Nakayama, K. I. (2016) · Nature · doi:10.1038/nature19357 · Cited by 353 · see citing works

Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

Jiménez, J. A., Ptacek, T., Tuttle, A. H., Schmid, R. S., Moy, S. S., Simon, J. M., & Zylka, M. J. (2020) · Molecular Autism · doi:10.1186/s13229-020-00369-8 · Cited by 36 · see citing works

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

Hurley, S., Mohan, C., Suetterlin, P., Ellingford, R. A., Riegman, K. L. H., Ellegood, J., Caruso, A., Michetti, C., Brock, O., Evans, R., et al. (2021) · Molecular Autism · doi:10.1186/s13229-020-00409-3 · Cited by 42 · see citing works

Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development

Yim, K., Baumgartner, M., Krenzer, M., Larios, M. F. R., Hill-Terán, G., Nottoli, T., Muhle, R., & Noonan, J. P. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100986 · Cited by 12 · see citing works

CHD8のハプロ不全はマウスに自閉症様の表現型をもたらす

Katayama, Y. (2018) · Institutional Repositories DataBase (IRDB)