Lafyatis, Robert

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Ziegler, C. G. K., Allon, S. J., Nyquist, S. K., Mbano, I. M., Miao, V. N., Tzouanas, C. N., Cao, Y., Yousif, A. S., Bals, J., Hauser, B. M., et al. (2020) · Cell

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 2,284

Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial

Khanna, D., Denton, C. P., Jahreis, A., van Laar, J. M., Frech, T. M., Anderson, M. E., Baron, M., Chung, L., Fierlbeck, G., Lakshminarayanan, S., et al. (2016) · The Lancet

Systemic Sclerosis and Related DiseasesRheumatoid Arthritis Research and Therapies

Cited by 683

Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung

Schupp, J. C., Adams, T. S., Cosme, C., Raredon, M. S. B., Yuan, Y., Omote, N., Poli, S., Chioccioli, M., Rose, K.-A., Manning, E. P., et al. (2021) · Circulation

Single-cell and spatial transcriptomicsPulmonary Hypertension Research and Treatments

Cited by 453

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette

Somers, A., Jean, J.-C., Sommer, C. A., Omari, A., Ford, C. C., Mills, J. A., Ying, L., Sommer, A. G., Jean, J. M., Smith, B. W., et al. (2010) · Stem Cells

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 423

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

Horan, G. S., Wood, S., Ona, V., Li, D. J., Lukashev, M. E., Weinreb, P. H., Simon, K. J., Hahm, K., Allaire, N. E., Rinaldi, N. J., et al. (2008) · American Journal of Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and Treatments

Cited by 420

Localization and actions of transforming growth factor-β s in the embryonic nervous system

Flanders, K. C., Lüdecke, G., Engels, S., Cissel, D. S., Roberts, A. B., Kondaiah, P., Lafyatis, R., Sporn, M. B., & Unsicker, K. (1991) · Development

Neurogenesis and neuroplasticity mechanismsTGF-β signaling in diseases

Cited by 359

Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients

Rice, L. M., Padilla, C. M., McLaughlin, S. R., Mathes, A., Ziemek, J., Goummih, S., Nakerakanti, S., York, M., Farina, G., Whitfield, M. L., et al. (2015) · Journal of Clinical Investigation

Systemic Sclerosis and Related DiseasesConnective tissue disorders research

Cited by 351

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?

Wei, J., Melichian, D., Komura, K., Hinchcliff, M., Lam, A. P., Lafyatis, R., Gottardi, C. J., MacDougald, O. A., & Varga, J. (2011) · Arthritis & Rheumatism

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 214

Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis

Denton, C. P., Ong, V. H., Xu, S., Chen-Harris, H., Modrusan, Z., Lafyatis, R., Khanna, D., Jahreis, A., Siegel, J., & Sornasse, T. (2018) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesTGF-β signaling in diseases

Cited by 166

Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions

Krieg, T., Abraham, D., & Lafyatis, R. (2007) · Arthritis Research & Therapy

Systemic Sclerosis and Related DiseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 151

Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis

Kissin, E. Y., Merkel, P. A., & Lafyatis, R. (2006) · Arthritis & Rheumatism

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 123

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3

Grebinoski, S., Zhang, Q., Cillo, A. R., Manne, S., Xiao, H., Brunazzi, E. A., Tabib, T., Cardello, C., Lian, C. G., Murphy, G. F., et al. (2022) · Nature Immunology

T-cell and B-cell ImmunologyDiabetes and associated disorders

Cited by 107

Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis

Stifano, G., Affandi, A. J., Mathes, A. L., Rice, L. M., Nakerakanti, S., Nazari, B., Lee, J., Christmann, R. B., & Lafyatis, R. (2014) · Arthritis Research & Therapy

Systemic Sclerosis and Related DiseasesImmune Response and Inflammation

Cited by 86

The relationship between skin symptoms and the scleroderma modification of the health assessment questionnaire, the modified Rodnan skin score, and skin pathology in patients with systemic sclerosis

Ziemek, J., Man, A., Hinchcliff, M., Varga, J., Simms, R. W., & Lafyatis, R. (2016) · Rheumatology

Systemic Sclerosis and Related DiseasesConnective tissue disorders research

Cited by 33

Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis

Samuel, G. H., Lenna, S., Bujor, A. M., Lafyatis, R., & Trojanowska, M. (2012) · Journal of Dermatological Science

Systemic Sclerosis and Related DiseasesSphingolipid Metabolism and Signaling

Cited by 22