Lako, Majlinda

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

Volpato, V., Smith, J., Sandor, C., Ried, J. S., Baud, A., Handel, A., Newey, S. E., Wessely, F., Attar, M., Whiteley, E., et al. (2018) · Stem Cell Reports

Pluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics

Cited by 165

Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells

Mellough, C. B., Sernagor, E., Moreno-Gimeno, I., Steel, D. H. W., & Lako, M. (2012) · Stem Cells

Retinal Development and DisordersPluripotent Stem Cells Research

Cited by 162

Overexpression of Telomerase Confers Growth Advantage, Stress Resistance, and Enhanced Differentiation of ESCs Toward the Hematopoietic Lineage

Armstrong, L., Saretzki, G., Peters, H., Wappler, I., Evans, J., Hole, N., von Zglinicki, T., & Lako, M. (2005) · Stem Cells

Telomeres, Telomerase, and SenescencePluripotent Stem Cells Research

Cited by 153

A Key Role for Telomerase Reverse Transcriptase Unit in Modulating Human Embryonic Stem Cell Proliferation, Cell Cycle Dynamics, and In Vitro Differentiation

Yang, C., Przyborski, S., Cooke, M. J., Zhang, X., Stewart, R., Anyfantis, G., Atkinson, S. P., Saretzki, G., Armstrong, L., & Lako, M. (2008) · Stem Cells

Telomeres, Telomerase, and SenescencePluripotent Stem Cells Research

Cited by 136

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

Mellough, C. B., Collin, J., Queen, R., Hilgen, G., Dorgau, B., Zerti, D., Felemban, M., White, K., Sernagor, E., & Lako, M. (2019) · Stem Cells Translational Medicine

Retinal Development and DisordersPluripotent Stem Cells Research

Cited by 85

Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions

Latta, L., Figueiredo, F. C., Ashery-Padan, R., Collinson, J. M., Daniels, J., Ferrari, S., Szentmáry, N., Solá, S., Shalom-Feuerstein, R., Lako, M., et al. (2021) · The Ocular Surface

Corneal Surgery and TreatmentsOcular Disorders and Treatments

Cited by 78

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure

Hallam, D., Collin, J., Bojic, S., Chichagova, V., Buskin, A., Xu, Y., Lafage, L., Otten, E. G., Anyfantis, G., Mellough, C., et al. (2017) · Stem Cells

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 75

Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease

Jiang, Y., Cowley, S. A., Siler, U., Melguizo, D., Tilgner, K., Browne, C., Dewilton, A., Przyborski, S., Saretzki, G., James, W. S., et al. (2012) · Stem Cells

Pluripotent Stem Cells ResearchImmunodeficiency and Autoimmune Disorders

Cited by 71

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids

Dorgau, B., Felemban, M., Hilgen, G., Kiening, M., Zerti, D., Hunt, N. C., Doherty, M., Whitfield, P., Hallam, D., White, K., et al. (2019) · Biomaterials

Retinal Development and DisordersTissue Engineering and Regenerative Medicine

Cited by 69

Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function

Cerniauskas, E., Kurzawa-Akanbi, M., Xie, L., Hallam, D., Moya-Molina, M., White, K., Steel, D., Doherty, M., Whitfield, P., Al-Aama, J., et al. (2020) · Stem Cells Translational Medicine

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 58

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent

Chichagova, V., Hilgen, G., Ghareeb, A., Georgiou, M., Carter, M., Sernagor, E., Lako, M., & Armstrong, L. (2020) · Stem Cells

Retinal Development and DisordersPluripotent Stem Cells Research

Cited by 58

AAV-mediated gene augmentation therapy restores critical functions in mutant iPSC-derived PRPF31 +/- cells

Brydon, E. M., Bronstein, R., Buskin, A., Lako, M., Pierce, E. A., & Fernandez-Godino, R. (2019) · Molecular Therapy — Methods & Clinical Development

Retinal Development and DisordersVirus-based gene therapy research

Cited by 56

Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration

Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 44

Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants

Tzoumas, N., Hallam, D., Harris, C. L., Lako, M., Kavanagh, D., & Steel, D. H. W. (2021) · Survey of Ophthalmology

Complement system in diseasesRetinal Diseases and Treatments

Cited by 33

Deciphering the Impact of PROM1 Alternative Splicing on Human Photoreceptor Development and Maturation

Lako, M., Molina, M. M., Dorgau, B., Flood, E., Letteboer, S., Lorentzen, E., Coxhead, J., Smith, G., Roepman, R., Nagaraja-Grellscheid, S., et al. (2024) · Cell Death and Disease

Retinal Development and DisordersRNA Research and Splicing

Cited by 11