Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway

Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey

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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

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Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

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Titanium Dioxide (P25) Produces Reactive Oxygen Species in Immortalized Brain Microglia (BV2): Implications for Nanoparticle Neurotoxicity

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The Role of TLR2 in Infection and Immunity

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AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

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Altered intestinal function in patients with chronic heart failure

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Pulmonary Responses of Mice, Rats, and Hamsters to Subchronic Inhalation of Ultrafine Titanium Dioxide Particles

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Toll-like receptors modulate adult hippocampal neurogenesis

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The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.

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Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

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Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: Acute toxicity, oxidative stress and oxidative damage

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N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial

Berk, M., Copolov, D. L., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., & Bush, A. I. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.022 · Cited by 500 · see citing works

Hydroxyl radicals (•OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells

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The Role of Free Radicals in the Toxic and Inflammatory Effects of Four Different Ultrafine Particle Types

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Chronic Fine Particulate Matter Exposure Induces Systemic Vascular Dysfunction via NADPH Oxidase and TLR4 Pathways

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Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene

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Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases

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Aluminum Hydroxide Adjuvants Activate Caspase-1 and Induce IL-1β and IL-18 Release

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Reactive Oxygen Species and the Pathogenesis of Radiocontrast-Induced Nephropathy

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Differential monocyte responses to TLR ligands in children with autism spectrum disorders

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Top-Down and Bottom-Up Mechanisms in Mind-Body Medicine: Development of an Integrative Framework for Psychophysiological Research

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The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter

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The importance of the gastrointestinal system in the pathogenesis of heart failure

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Psychosocial interventions for reducing fatigue during cancer treatment in adults

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Pathways of cholesterol oxidation via non-enzymatic mechanisms

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Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles

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Molecular Mechanisms of Hypertension—Reactive Oxygen Species and Antioxidants: A Basic Science Update for the Clinician

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Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

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A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal

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Inhibition of homodimerization of Toll-like receptor 4 by curcumin

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Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles

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In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS‐damaged neoepitopes

Maes, M. H. J., Kubera, M., Leunis, J., Berk, M., Geffard, M., & Bosmans, E. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2012.01908.x · Cited by 209 · see citing works

Advances in Carcinogenic Metal Toxicity and Potential Molecular Markers

Koedrith, P., & Seo, Y. R. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12129576 · Cited by 209 · see citing works

Signaling pathway of inflammatory responses in the mouse liver caused by TiO 2 nanoparticles

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Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): Indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut–intestinal permeability

Maes, M., Mihaylova, I., & Leunis, J.-C. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.08.021 · Cited by 197 · see citing works

The role of long-lived reactive oxygen intermediates in the reaction of ozone with aerosol particles

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Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke

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Molecular Hydrogen Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice Through Reducing Inflammation and Apoptosis

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Suppression of MyD88- and TRIF-dependent signaling pathways of toll-like receptor by (−)-epigallocatechin-3-gallate, a polyphenol component of green tea

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Neurotoxins: Free radical mechanisms and melatonin protection

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Prevalence of small intestinal bacterial overgrowth in Parkinson’s disease

Gabrielli, M., Bonazzi, P., Scarpellini, E., Bendia, E., Lauritano, E. C., Fasano, A., Ceravolo, M. G., Capecci, M., Rita Bentivoglio, A., Provinciali, L., et al. (2011) · Movement Disorders · doi:10.1002/mds.23566 · Cited by 175 · see citing works

Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome

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Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases

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Alzheimer's Disease and Peripheral Infections: The Possible Contribution from Periodontal Infections, Model and Hypothesis

Kamer, A. R., Dasanayake, A. P., Craig, R. G., Głodzik-Sobańska, L., Bry, M., & de Leon, M. J. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13408 · Cited by 166 · see citing works

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

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C-Reactive Protein–Induced In Vitro Endothelial Cell Activation Is an Artefact Caused by Azide and Lipopolysaccharide

Taylor, K. E., Giddings, J. C., & van den Berg, C. W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000164623.41250.28 · Cited by 157 · see citing works

Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease

Ochoa‐Repáraz, J., Mielcarz, D. W., Haque, S., & Kasper, L. H. (2010) · Annals of Neurology · doi:10.1002/ana.22344 · Cited by 155 · see citing works

Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2

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Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2

Raghavan, B., Martin, S. F., Esser, P. R., Goebeler, M., & Schmidt, M. (2012) · EMBO Reports · doi:10.1038/embor.2012.155 · Cited by 143 · see citing works

Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis

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Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma

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The emerging role of the gut in chronic heart failure

Sandek, A., Rauchhaus, M., Anker, S. D., & von Haehling, S. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32830a4c6e · Cited by 134 · see citing works

Nitration Enhances the Allergenic Potential of Proteins

Gruijthuijsen, Y. K., Grieshuber, I., Stöcklinger, A., et al. (2006) · International Archives of Allergy and Immunology · doi:10.1159/000095296 · Cited by 133 · see citing works

Intrinsic and Extrinsic Regulation of Innate Immune Receptors

Jeong, E., & Lee, J. Y. (2011) · Yonsei Medical Journal · doi:10.3349/ymj.2011.52.3.379 · Cited by 132 · see citing works

Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype

McKernan, D. P., Dennison, U., Gaszner, G., Cryan, J. F., & Dinan, T. G. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.37 · Cited by 131 · see citing works

Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

Amyot, J., Semache, M., Ferdaoussi, M., Fontès, G., & Poitout, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036200 · Cited by 127 · see citing works

Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia

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Ozone and Pulmonary Innate Immunity

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Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway

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Neural injury following stroke: are Toll‐like receptors the link between the immune system and the CNS?

Downes, C., & Crack, P. J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00864.x · Cited by 123 · see citing works

Neurotoxic Effects of Lipopolysaccharide on Nigral Dopaminergic Neurons Are Mediated by Microglial Activation, Interleukin-1β, and Expression of Caspase-11 in Mice

Arai, H., Furuya, T., Yasuda, T., Miura, M., Mizuno, Y., & Mochizuki, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407328200 · Cited by 122 · see citing works

Salvianolic Acid B Inhibits Hydrogen Peroxide-Induced Endothelial Cell Apoptosis through Regulating PI3K/Akt Signaling

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A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome

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N-acetylcysteine for major depressive episodes in bipolar disorder

Magalhães, P. V. D. S., Dean, O. M., Bush, A. I., Copolov, D., Malhi, G. S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson‐Hunt, M., & Berk, M. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000400011 · Cited by 113 · see citing works

Potential Mechanism for Pentachlorophenol-Induced Carcinogenicity: A Novel Mechanism for Metal-Independent Production of Hydroxyl Radicals

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Biophysical Mechanisms of Endotoxin Neutralization by Cationic Amphiphilic Peptides

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Measurements of fine and ultrafine particles formation in photocopy centers in Taiwan

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Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner

Honda, H., Nagai, Y., Matsunaga, T., Saitoh, S.-I., Akashi‐Takamura, S., Hayashi, H., Fujii, I., Miyake, K., Muraguchi, A., & Takatsu, K. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0112038 · Cited by 109 · see citing works

N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling

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Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats

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Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages

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TLR4 Is Necessary for Hyaluronan-mediated Airway Hyperresponsiveness after Ozone Inhalation

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Anesthetic Propofol Reduces Endotoxic Inflammation by Inhibiting Reactive Oxygen Species-regulated Akt/IKKβ/NF-κB Signaling

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Stress Mediators Regulate Brain Prostaglandin Synthesis and Peroxisome Proliferator-Activated Receptor-γ Activation after Stress in Rats

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Ionizing radiation stimulates secretion of pro-inflammatory cytokines: dose–response relationship, mechanisms and implications

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Cinnamon Extract Protects against Acute Alcohol-Induced Liver Steatosis in Mice

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ROLE OF BACTERIAL ENDOTOXIN IN CHRONIC HEART FAILURE

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Baicalin Inhibits TLR2/4 Signaling Pathway in Rat Brain Following Permanent Cerebral Ischemia

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Intestinal Permeability and Function in Patients Infected with Human Immunodeficiency Virus: A Comparison with Coeliac Disease

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Influence of Fasting on Intestinal Permeability and Disease Activity in Patients with Rheumatoid Arthritis

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N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: Behavioral and biochemical analyses in rats

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Toll-Like Receptor Priming Sensitizes Macrophages to Proinflammatory Cytokine Gene Induction by Deoxynivalenol and Other Toxicants

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Role of Reactive Oxygen Metabolites in Organophosphate-Bidrin-Induced Renal Tubular Cytotoxicity

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Neuroimaging in Drug and Substance Abuse Part II

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