Clarner, Tim

The cuprizone animal model: new insights into an old story

Kipp, M., Clarner, T., Dang, J., Copray, S., & Beyer, C. (2009) · Acta Neuropathologica

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 481

Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions

Clarner, T., Diederichs, F., Berger, K., Denecke, B., Gan, L., van der Valk, P., Beyer, C., Amor, S., & Kipp, M. (2012) · Glia

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 155

CXCL10 Triggers Early Microglial Activation in the Cuprizone Model

Clarner, T., Janssen, K., Nellessen, L., Stangel, M., Skripuletz, T., Krauspe, B., Hess, F.-M., Denecke, B., Beutner, C., Linnartz-Gerlach, B., et al. (2015) · The Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 150

Inflammatory Response and Chemokine Expression in the White Matter Corpus Callosum and Gray Matter Cortex Region During Cuprizone-Induced Demyelination

Buschmann, J. P., Berger, K., Awad, H., Clarner, T., Beyer, C., & Kipp, M. (2012) · Journal of Molecular Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 133

Cuprizone treatment induces demyelination and astrocytosis in the mouse hippocampus

Norkute, A., Hieble, A., Braun, A., Johann, S., Clarner, T., Baumgartner, W., Beyer, C., & Kipp, M. (2009) · Journal of Neuroscience Research

Multiple Sclerosis Research StudiesNeurological Disease Mechanisms and Treatments

Cited by 123

Cuprizone Treatment Induces Distinct Demyelination, Astrocytosis, and Microglia Cell Invasion or Proliferation in the Mouse Cerebellum

Groebe, A., Clarner, T., Baumgartner, W., Dang, J., Beyer, C., & Kipp, M. (2009) · The Cerebellum

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 116

Anatomical Distribution of Cuprizone-Induced Lesions in C57BL6 Mice

Goldberg, J., Clarner, T., Beyer, C., & Kipp, M. (2015) · Journal of Molecular Neuroscience

Multiple Sclerosis Research StudiesNeurological Disease Mechanisms and Treatments

Cited by 96

Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model: Astrocytic Nrf2 Hyperactivation Prevents the Formation of Demyelinating Lesions

Draheim, T., Liessem, A., Scheld, M., Wilms, F., Weißflog, M., Denecke, B., Kensler, T. W., Zendedel, A., Beyer, C., Kipp, M., et al. (2016) · Glia

Multiple Sclerosis Research StudiesGenomics, phytochemicals, and oxidative stress

Cited by 95

The sphingosine 1‐phosphate receptor agonist FTY 720 is neuroprotective after cuprizone‐induced CNS demyelination

Slowik, A., Schmidt, T., Beyer, C., Amor, S., Clarner, T., & Kipp, M. (2015) · British Journal of Pharmacology

Multiple Sclerosis Research StudiesSphingolipid Metabolism and Signaling

Cited by 94

Cuprizone effect on myelination, astrogliosis and microglia attraction in the mouse basal ganglia

Pott, F., Gingele, S., Clarner, T., Dang, J., Baumgartner, W., Beyer, C., & Kipp, M. (2009) · Brain Research

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 85

BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions

Kipp, M., Gingele, S., Pott, F., Clarner, T., van der Valk, P., Denecke, B., Gan, L., Siffrin, V., Zipp, F., Dreher, W., et al. (2011) · Brain, Behavior, and Immunity

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 83

Neurodegeneration Triggers Peripheral Immune Cell Recruitment into the Forebrain

Scheld, M., Rüther, B. J., Große-Veldmann, R., Ohl, K., Tenbrock, K., Dreymüller, D., Fallier-Becker, P., Zendedel, A., Beyer, C., Clarner, T., et al. (2016) · The Journal of Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 82

Combination of cuprizone and experimental autoimmune encephalomyelitis to study inflammatory brain lesion formation and progression

Rüther, B. J., Scheld, M., Dreymueller, D., Clarner, T., Kress, E., Brandenburg, L., Swartenbroekx, T., Hoornaert, C., Ponsaerts, P., Fallier‐Becker, P., et al. (2017) · Glia

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 76

Short-Term Cuprizone Feeding Induces Selective Amino Acid Deprivation with Concomitant Activation of an Integrated Stress Response in Oligodendrocytes

Goldberg, J., Daniel, M., van Heuvel, Y., Victor, M., Beyer, C., Clarner, T., & Kipp, M. (2013) · Cellular and Molecular Neurobiology

Endoplasmic Reticulum Stress and DiseaseMultiple Sclerosis Research Studies

Cited by 62

Regional heterogeneity of cuprizone-induced demyelination: Topographical aspects of the midline of the corpus callosum

Schmidt, T., Awad, H., Slowik, A., Beyer, C., Kipp, M., & Clarner, T. (2013) · Journal of Molecular Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 49

Acute axonal damage in three different murine models of multiple sclerosis: A comparative approach

Höflich, K. M., Beyer, C., Clarner, T., Schmitz, C., Nyamoya, S., Kipp, M., & Hochstrasser, T. (2016) · Brain Research

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 46

Cuprizone-induced graded oligodendrocyte vulnerability is regulated by the transcription factor DNA damage-inducible transcript 3

Fischbach, F., Nedelcu, J., Leopold, P., Zhan, J., Clarner, T., Nellessen, L., Beißel, C., van Heuvel, Y., Goswami, A., Weis, J., et al. (2019) · Glia

Multiple Sclerosis Research StudiesEndoplasmic Reticulum Stress and Disease

Cited by 45

Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain

Azami Tameh, A., Clarner, T., Beyer, C., Atlasi, M. A., Hassanzadeh, G., & Naderian, H. (2013) · Annals of Anatomy - Anatomischer Anzeiger

Neuroscience and Neuropharmacology ResearchMultiple Sclerosis Research Studies

Cited by 43

Brain lipid binding protein (FABP7) as modulator of astrocyte function

KIPP, M., CLARNER, T., GINGELE, S., POTT, F., AMOR, S., VAN DER VALK, P., & BEYER, C. (2011) · Physiological Research

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 42

Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5

Behrangi, N., Heinig, L., Frintrop, L., Santrau, E., Kurth, J., Krause, B., Atanasova, D., Clarner, T., Fragoulis, A., Joksch, M., et al. (2022) · Proceedings of the National Academy of Sciences

Multiple Sclerosis Research StudiesSphingolipid Metabolism and Signaling

Cited by 27

Short-Term Cuprizone Feeding Verifies N-Acetylaspartate Quantification as a Marker of Neurodegeneration

Krauspe, B. M., Dreher, W., Beyer, C., Baumgartner, W., Denecke, B., Janssen, K., Langhans, C.-D., Clarner, T., & Kipp, M. (2015) · Journal of Molecular Neuroscience

Advanced MRI Techniques and ApplicationsMultiple Sclerosis Research Studies

Cited by 22

Oligodendrocyte degeneration and concomitant microglia activation directs peripheral immune cells into the forebrain

Chrzanowski, U., Bhattarai, S., Scheld, M., Clarner, T., Fallier-Becker, P., Beyer, C., Rohr, S. O., Schmitz, C., Hochstrasser, T., Schweiger, F., et al. (2019) · Neurochemistry International

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 18

Mitochondrial Impairment in Oligodendroglial Cells Induces Cytokine Expression and Signaling

Scheld, M., Fragoulis, A., Nyamoya, S., Zendedel, A., Denecke, B., Krauspe, B., Teske, N., Kipp, M., Beyer, C., & Clarner, T. (2019) · Journal of Molecular Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 17