Lettice, Laura A.

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

Lettice, L. A. (2003) · Human Molecular Genetics

Congenital limb and hand anomaliesGenomics and Chromatin Dynamics

Cited by 1,164

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

Reijns, M. A. M., Rabe, B., Rigby, R. E., Mill, P., Astell, K. R., Lettice, L. A., Boyle, S., Leitch, A., Keighren, M., Kilanowski, F., et al. (2012) · Cell

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 466

Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

Mackenzie, K. J., Carroll, P., Lettice, L., Tarnauskaitė, Ž., Reddy, K., Dix, F., Revuelta, A., Abbondati, E., Rigby, R. E., Rabe, B., et al. (2016) · The EMBO Journal

interferon and immune responsesSystemic Lupus Erythematosus Research

Cited by 248

Opposing Functions of the ETS Factor Family Define Shh Spatial Expression in Limb Buds and Underlie Polydactyly

Lettice, L. A., Williamson, I., Wiltshire, J. H., Peluso, S., Devenney, P. S., Hill, A. E., Essafi, A., Hagman, J., Mort, R., Grimes, G., et al. (2012) · Developmental Cell

Hedgehog Signaling Pathway StudiesCongenital limb and hand anomalies

Cited by 153

Cohesin is required for long-range enhancer action at the Shh locus

Kane, L., Williamson, I., Flyamer, I. M., Kumar, Y., Hill, R. E., Lettice, L. A., & Bickmore, W. A. (2022) · Nature Structural & Molecular Biology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 153

Developmentally regulated Shh expression is robust to TAD perturbations

Williamson, I., Kane, L., Devenney, P. S., Anderson, E., Kilanowski, F., Hill, R. E., Bickmore, W. A., & Lettice, L. A. (2019) · Development

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 138

Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity

Williamson, I., Lettice, L. A., Hill, R. E., & Bickmore, W. A. (2016) · Development

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 124

Identification of Sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch

Sharpe, J., Lettice, L., Hecksher-Sørensen, J., Fox, M., Hill, R., & Krumlauf, R. (1999) · Current Biology

Congenital limb and hand anomaliesHedgehog Signaling Pathway Studies

Cited by 104

The Conserved Sonic Hedgehog Limb Enhancer Consists of Discrete Functional Elements that Regulate Precise Spatial Expression

Lettice, L. A., Devenney, P., De Angelis, C., & Hill, R. E. (2017) · Cell Reports

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 70

Anterior-posterior differences in HoxD chromatin topology in limb development

Williamson, I., Eskeland, R., Lettice, L. A., Hill, A. E., Boyle, S., Grimes, G. R., Hill, R. E., & Bickmore, W. A. (2012) · Development

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 62

Cohesin is required for long-range enhancer action

Kane, L., Williamson, I., Flyamer, I. M., Kumar, Y., Hill, R. E., Lettice, L. A., & Bickmore, W. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 23