Gilbert, Luke A.

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013) · Cell

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 5,016

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Gilbert, L. A., Larson, M. H., Morsut, L., Liu, Z., Brar, G. A., Torres, S. E., Stern-Ginossar, N., Brandman, O., Whitehead, E. H., Doudna, J. A., et al. (2013) · Cell

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 3,696

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

Gilbert, L. A., Horlbeck, M. A., Adamson, B., Villalta, J. E., Chen, Y., Whitehead, E. H., Guimaraes, C., Panning, B., Ploegh, H. L., Bassik, M. C., et al. (2014) · Cell

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 2,728

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Adamson, B., Norman, T. M., Jost, M., Cho, M. Y., Nuñez, J. K., Chen, Y., Villalta, J. E., Gilbert, L. A., Horlbeck, M. A., Hein, M. Y., et al. (2016) · Cell

Endoplasmic Reticulum Stress and DiseaseSingle-cell and spatial transcriptomics

Cited by 1,193

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds

Zalatan, J. G., Lee, M. E., Almeida, R., Gilbert, L. A., Whitehead, E. H., La Russa, M., Tsai, J. C., Weissman, J. S., Dueber, J. E., Qi, L. S., et al. (2015) · Cell

CRISPR and Genetic EngineeringGene Regulatory Network Analysis

Cited by 938

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

Horlbeck, M. A., Gilbert, L. A., Villalta, J. E., Adamson, B., Pak, R. A., Chen, Y., Fields, A. P., Park, C. Y., Corn, J. E., Kampmann, M., et al. (2016) · eLife

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 894

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

Nuñez, J. K., Chen, J., Pommier, G. C., Cogan, J. Z., Replogle, J. M., Adriaens, C., Ramadoss, G. N., Shi, Q., Hung, K. L., Samelson, A. J., et al. (2021) · Cell

CRISPR and Genetic EngineeringEpigenetics and DNA Methylation

Cited by 760

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer

Quigley, D. A., Dang, H. X., Zhao, S. G., Lloyd, P., Aggarwal, R., Alumkal, J. J., Foye, A., Kothari, V., Perry, M. D., Bailey, A. M., et al. (2018) · Cell

Prostate Cancer Treatment and ResearchCancer Genomics and Diagnostics

Cited by 733

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

Mandegar, M. A., Huebsch, N., Frolov, E. B., Shin, E., Truong, A., Olvera, M. P., Chan, A. H., Miyaoka, Y., Holmes, K., Spencer, C. I., et al. (2016) · Cell Stem Cell

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 525

DNA Damage-Mediated Induction of a Chemoresistant Niche

Gilbert, L. A., & Hemann, M. T. (2010) · Cell

Lymphoma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 428

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

Norman, T. M., Horlbeck, M. A., Replogle, J. M., Ge, A. Y., Xu, A., Jost, M., Gilbert, L. A., & Weissman, J. S. (2019) · Science

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 392

Mapping the Genetic Landscape of Human Cells

Horlbeck, M. A., Xu, A., Wang, M., Bennett, N. K., Park, C. Y., Bogdanoff, D., Adamson, B., Chow, E. D., Kampmann, M., Peterson, T. R., et al. (2018) · Cell

CRISPR and Genetic EngineeringBioinformatics and Genomic Networks

Cited by 319

A new era in functional genomics screens

Przybyla, L., & Gilbert, L. A. (2022) · Nature Reviews Genetics

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 281

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses.

Bent, E. H., Gilbert, L. A., & Hemann, M. T. (2016) · Genes & Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 179

KRAS G12C inhibition produces a driver-limited state revealing collateral dependencies

Lou, K., Steri, V., Ge, A. Y., Hwang, Y. C., Yogodzinski, C. H., Shkedi, A. R., Choi, A. L. M., Mitchell, D. C., Swaney, D. L., Hann, B., et al. (2019) · Science Signaling

Protein Kinase Regulation and GTPase SignalingCancer Genomics and Diagnostics

Cited by 175

Predicting cellular responses to perturbation across diverse contexts with State

Adduri, A. K., Gautam, D., Bevilacqua, B., Naghipourfar, M., Imran, A., Shah, R., Teyssier, N., Verma, R., Carpenter, C., Eraslan, B., et al. (2026) · Cell

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 100

Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle

Ietswaart, R., Smalec, B. M., Xu, A., Choquet, K., McShane, E., Jowhar, Z. M., Guegler, C. K., Baxter-Koenigs, A. R., West, E. R., Fu, B. X. H., et al. (2024) · Molecular Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 83

IFITM proteins assist cellular uptake of diverse linked chemotypes

Lou, K., Wassarman, D. R., Yang, T., Paung, Y., Zhang, Z., O’Loughlin, T. A., Moore, M. K., Egan, R. K., Greninger, P., Benes, C. H., et al. (2022) · Science

Drug Transport and Resistance MechanismsRNA Interference and Gene Delivery

Cited by 42

An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

Das, R., Sjöström, M., Shrestha, R., Yogodzinski, C., Egusa, E. A., Chesner, L. N., Chen, W. S., Chou, J., Dang, D. K., Swinderman, J. T., et al. (2021) · Nature Communications

Prostate Cancer Treatment and ResearchChromatin Remodeling and Cancer

Cited by 38

Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer

Li, H., Melnyk, J. E., Fu, B. X. H., Shrestha, R., Zhang, M., Sjöström, M., Feng, S., Anderson, J. A., Han, W., Chesner, L. N., et al. (2025) · Nature Genetics

Prostate Cancer Treatment and ResearchChromatin Remodeling and Cancer

Cited by 10

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

Ge, A. Y., Arab, A., Dai, R., Navickas, A., Fish, L., Garcia, K., Asgharian, H., Goudreau, J., Lee, S., Keenan, K., et al. (2024) · Scientific Reports

Epigenetics and DNA MethylationAcute Myeloid Leukemia Research

Cited by 4