Karran, Peter

Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

Karran, P., & Attard, N. (2008) · Nature Reviews Cancer

Carcinogens and Genotoxicity AssessmentImmunotoxicology and immune responses

Cited by 477

Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light

Zhang, X., Jeffs, G., Ren, X., O’Donovan, P., Montaner, B., Perrett, C. M., Karran, P., & Xu, Y.-Z. (2007) · DNA Repair

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 110

UVA photosensitization of thiopurines and skin cancer in organ transplant recipients

Attard, N. R., & Karran, P. (2012) · Photochemical & Photobiological Sciences

Skin Protection and AgingNonmelanoma Skin Cancer Studies

Cited by 94

Oxidative stress-induced protein damage inhibits DNA repair and determines mutation risk and therapeutic efficacy

McAdam, E., Brem, R., & Karran, P. (2016) · Molecular Cancer Research

DNA Repair MechanismsSkin Protection and Aging

Cited by 86

4-thiothymidine sensitization of DNA to UVA offers potential for a novel photochemotherapy

Reelfs, O., Karran, P., & Young, A. R. (2012) · Photochemical & Photobiological Sciences

Photodynamic Therapy Research StudiesDNA and Nucleic Acid Chemistry

Cited by 79

Multiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6‐Thioguanine

Brem, R., & Karran, P. (2012) · Photochemistry and Photobiology

Carcinogens and Genotoxicity AssessmentSkin Protection and Aging

Cited by 76

Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions

Brem, R., Li, F., & Karran, P. (2009) · Nucleic Acids Research

DNA Repair MechanismsSkin Protection and Aging

Cited by 67

Oxidative damage to RPA limits the nucleotide excision repair capacity of human cells

Guven, M., Brem, R., Macpherson, P., Peacock, M., & Karran, P. (2015) · Journal of Investigative Dermatology

DNA Repair MechanismsSkin Protection and Aging

Cited by 61

Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation

Ren, X., Li, F., Jeffs, G., Zhang, X., Xu, Y.-Z., & Karran, P. (2010) · Nucleic Acids Research

Carcinogens and Genotoxicity AssessmentDNA and Nucleic Acid Chemistry

Cited by 55

Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation

Brem, R., Daehn, I., & Karran, P. (2011) · DNA Repair

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 48

Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA

Gueranger, Q., Kia, A., Frith, D., & Karran, P. (2011) · Nucleic Acids Research

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 47

DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation

Brem, R., Li, F., Montaner, B., Reelfs, O., & Karran, P. (2010) · Oncogene

DNA Repair MechanismsSkin Protection and Aging

Cited by 42

Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells

Reelfs, O., Macpherson, P., Ren, X., Xu, Y.-Z., Karran, P., & Young, A. R. (2011) · Nucleic Acids Research

Photodynamic Therapy Research StudiesDNA Repair Mechanisms

Cited by 36

Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status

Reelfs, O., Xu, Y.-Z., Massey, A., Karran, P., & Storey, A. (2007) · Molecular Cancer Therapeutics

Photodynamic Therapy Research StudiesSkin Protection and Aging

Cited by 30